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ChemicalBook >> CAS DataBase List >>N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Structure
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine structure
CAS No.
55778-02-4
Chemical Name:
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
Synonyms
WZ 811;CS-567;DK7350;WZ-811; WZ811;WZ 811, >=98%;N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine;N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine;1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl-;N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE;N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine)
CBNumber:
CB62518930
Molecular Formula:
C18H18N4
Molecular Weight:
290.36
MDL Number:
MFCD18086914
MOL File:
55778-02-4.mol
MSDS File:
SDS
Last updated:2023-06-08 17:06:36
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N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Properties

Melting point 192-194℃ (methanol )
Boiling point 493.2±35.0 °C(Predicted)
Density 1.229±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO: ≥7mg/mL
pka 6.55±0.10(Predicted)
form powder
color white to tan

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  3
HS Code  2933.39.6190
NFPA 704
0
2 0

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0088 WZ 811 ≥98% (HPLC) 55778-02-4 5mg $104 2024-03-01 Buy
Sigma-Aldrich SML0088 WZ 811 ≥98% (HPLC) 55778-02-4 25mg $397 2023-01-07 Buy
TCI Chemical W0017 WZ 811 55778-02-4 25MG $64 2024-03-01 Buy
TCI Chemical W0017 WZ 811 55778-02-4 100MG $175 2024-03-01 Buy
Cayman Chemical 13639 WZ 811 ≥95% 55778-02-4 1mg $19 2024-03-01 Buy
Product number Packaging Price Buy
SML0088 5mg $104 Buy
SML0088 25mg $397 Buy
W0017 25MG $64 Buy
W0017 100MG $175 Buy
13639 1mg $19 Buy

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Chemical Properties,Uses,Production

Description

The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4 on CD4+ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. WZ811 is a potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM). It prevents SDF-1/CXCL12-mediated modulation of cAMP (EC50 = 1.2 nM) in cells and blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM). The effectiveness of WZ811 in animals remains to be elucidated.

Uses

N1,N4-di-2-Pyridinyl-1,4-benzenedimethanamine acts as an inhibitor for the chemokine receptor CXCR4.

References

[1] zhan w, liang z, zhu a, et al. discovery of small molecule cxcr4 antagonists. journal of medicinal chemistry, 2007, 50(23): 5655-5664.
[2] choi w t, duggineni s, xu y, et al. drug discovery research targeting the cxc chemokine receptor 4 (cxcr4). journal of medicinal chemistry, 2011, 55(3): 977-994.

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Preparation Products And Raw materials

Raw materials

Preparation Products

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Suppliers

Global( 118)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12377 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29627 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Alfa Chemistry 		58

View Lastest Price from N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine pictures 2019-09-04 N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
55778-02-4
 US $5.00 / KG 1KG 99% 1ton Career Henan Chemical Co

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Spectrum

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine(55778-02-4)1HNMR

55778-02-4(N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine)Related Search:

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1of3

1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl- N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine WZ811 WZ 811 N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine WZ 811, >=98% N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine WZ 811 N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine) WZ-811; WZ811 CS-567 N-[[4-[(pyridin-2-ylamino)methyl]phenyl]methyl]pyridin-2-amine N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine USP/EP/BP DK7350 Inhibitor,inhibit,WZ811,WZ 811,CXCR,WZ-811,CXC chemokine receptors 55778-02-4 Inhibitors