ChemicalBook >> CAS DataBase List >>5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione structure

CAS No.: 958852-01-2

Chemical Name:: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

Synonyms: CS-536;CS-1726;GSK-615;CS-1156;SK1059615;GSK 1059615;GSK 1059615;GSK-1059615;PI3K inhibitor GS1059615;GSK 1059615 SodiuM Salt Hydrate;GSK1059615;GSK 1059615; GSK-1059615

CBNumber:: CB62518985

Molecular Formula:: C18H11N3O2S

Molecular Weight:: 333.36

MDL Number:: MFCD18074517

MOL File:: 958852-01-2.mol

Last updated:2023-05-18 11:31:15

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5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Properties

Melting point	>290°C (dec.)
storage temp.	Store at +4°C
solubility	H2O: ≥8mg/mL
form	powder
color	yellow
FDA UNII	07YMO87363

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3

5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0083	GSK 1059615 sodium salt hydrate	958852-01-2	10mg	$120	2024-03-01	Buy
Sigma-Aldrich	SML0083	GSK 1059615 sodium salt hydrate	958852-01-2	50mg	$489	2024-03-01	Buy
Cayman Chemical	11569	GSK1059615 ≥98%	958852-01-2	5mg	$93	2024-03-01	Buy
Cayman Chemical	11569	GSK1059615 ≥98%	958852-01-2	10mg	$111	2024-03-01	Buy
Cayman Chemical	11569	GSK1059615 ≥98%	958852-01-2	25mg	$252	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0083	10mg	$120	Buy
SML0083	50mg	$489	Buy
11569	5mg	$93	Buy
11569	10mg	$111	Buy
11569	25mg	$252	Buy

5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Chemical Properties,Uses,Production

Uses

GSK 1059615 is a potent inhibitor of PI 3-kinase and FRAP (mTOR).

Uses

GSK 1059615 is a potent inhibitor of PI 3-kinase α (PI3Kα). GSK 1059615 inhibits proliferation in BT474 cells and attenuates MAPK signaling.

Definition

ChEBI: GSK1059615 is a thiazolidinone that is the 5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene} derivative of 1,3-thiazolidine-2,4-dione. A PI3K inhibitor It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an antineoplastic agent. It is a member of quinolines, a member of pyridines and a thiazolidinone.

Biological Activity

gsk1059615 is inhibitor of pan-pi3k with ic50 values of 0.4nm, 0.6nm, 5nm, 2nm and 12nm for pi3kα, p13kβ, p13kγ, p13kδ and mtor, respectively [1].gsk1059615 is a potent and reversible inhibitor of p13k. it also has inhibition efficacy to the oncogenic mutants of pi3kα. the thiazolidinedione ring of gsk1059615 forms an interaction with the catalytic lysine (lys833) within the atp-binding pocket. in cellular assay, gsk1059615 is reported to induce g1 arrest and apoptosis in a variety of cell lines. among these, the breast tumor cells display more sensitive. moreover, gsk1059615 significantly suppresses tumor growth and increases plasma insulin levels in xenograft mice [1, 2].

References

[1] carnero a. novel inhibitors of the pi3k family. 2009.
[2] knight s d, adams n d, burgess j l, et al. discovery of gsk2126458, a highly potent inhibitor of pi3k and the mammalian target of rapamycin. acs medicinal chemistry letters, 2010, 1(1): 39-43.

5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Preparation Products And Raw materials

Raw materials

Preparation Products

5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Suppliers

Global( 111)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29322	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9821	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
changzhou huayang technology co., ltd	58

View Lastest Price from 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione 958852-01-2	US $1000.00-950.00 / KG	1MG	98%	100kg	Career Henan Chemical Co

5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
958852-01-2
US $1000.00-950.00 / KG
98%
Career Henan Chemical Co

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5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione GSK 1059615 (5Z)-5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione GSK 1059615 SodiuM Salt Hydrate SK1059615 (5Z)-5-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione sodium salt hydrate GSK-615 GSK1059615;GSK 1059615; GSK-1059615 GSK 1059615;GSK-1059615 PI3K inhibitor GS1059615 CS-1726 CS-536 CS-1156 2,4-Thiazolidinedione, 5-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-, (5Z)- 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione USP/EP/BP 958852-01-2 Akt mTOR PI3K Pharmaceuticals Sulfur & Selenium Compounds Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals