ChemicalBook >> CAS DataBase List >>PF-04457845
PF-04457845
- CAS No.
- 1020315-31-4
- Chemical Name:
- PF-04457845
- Synonyms
- CS-1549;PF-04457845;PF-04457845;PF04457845;PF-04457845 >=98% (HPLC);Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide;1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
- CBNumber:
- CB62522724
- Molecular Formula:
- C23H20F3N5O2
- Molecular Weight:
- 455.43
- MDL Number:
- MFCD18782721
- MOL File:
- 1020315-31-4.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Boiling point | 687.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.389±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml |
| pka | 12.72±0.20(Predicted) |
| form | powder |
| color | white to beige |
| FDA UNII | H4C81M8YYW |
PF-04457845 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0184 | PF-04457845 ≥98% (HPLC) | 1020315-31-4 | 5MG | $108 | 2023-06-20 | Buy |
| Sigma-Aldrich | PZ0184 | PF-04457845 ≥98% (HPLC) | 1020315-31-4 | 25MG | $438 | 2023-06-20 | Buy |
| Cayman Chemical | 19306 | PF-04457845 ≥98% | 1020315-31-4 | 5mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 19306 | PF-04457845 ≥98% | 1020315-31-4 | 10mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 19306 | PF-04457845 ≥98% | 1020315-31-4 | 25mg | $286 | 2024-03-01 | Buy |
PF-04457845 Chemical Properties,Uses,Production
Biochem/physiol Actions
PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.
storage
Store at +4°C
Synthesis of PF-04457845 from CarbaMic acid, N-3-pyridazinyl-, phenyl ester and Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1)
PF-04457845 Preparation Products And Raw materials
Raw materials
Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1)
Phosphonic acid, P-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methyl]-, diethyl ester
CarbaMic acid, N-3-pyridazinyl-, phenyl ester
BenzeneMethanol, 3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]-
Pyridine, 2-[3-(chloroMethyl)phenoxy]-5-(trifluoroMethyl)-
1of2
Preparation Products
Global( 69)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
PF-04457845
N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide
PF-04457845;PF04457845
1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide
CS-1549
PF-04457845 >=98% (HPLC)
Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor
1020315-31-4
C23H20F3N5O2