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2'-deoxy-2'-fluoro-2'-C-methyluridine

2'-deoxy-2'-fluoro-2'-C-methyluridine structure

CAS No.: 863329-66-2

Chemical Name:: 2'-deoxy-2'-fluoro-2'-C-methyluridine

Synonyms: CS-832;RO 2433;PSI-6206;GS-331007;PSI 6206 int;sofosbuvir INT;Sofosbuvir INT 1;-fluoroguanosine;-C-methyluridine;Sofosbuvir imp-11

CBNumber:: CB62525846

Molecular Formula:: C10H13FN2O5

Molecular Weight:: 260.22

MDL Number:: MFCD19982668

MOL File:: 863329-66-2.mol

Last updated:2024-04-08 17:36:13

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2'-deoxy-2'-fluoro-2'-C-methyluridine Properties

Melting point	237-238℃
Density	1.55
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	9.39±0.10(Predicted)
form	Solid
color	White to Light Beige
FDA UNII	44V7045CXS

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H319-H335-H315
Precautionary statements	P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code	2934.99.4400

2'-deoxy-2'-fluoro-2'-C-methyluridine price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D4823	(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine >98.0%(HPLC)(T)	863329-66-2	200mg	$122	2024-03-01	Buy
TCI Chemical	D4823	(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine >98.0%(HPLC)(T)	863329-66-2	1g	$428	2024-03-01	Buy
Cayman Chemical	18391	PSI-6206 ≥98%	863329-66-2	50mg	$32	2024-03-01	Buy
Cayman Chemical	18391	PSI-6206 ≥98%	863329-66-2	100mg	$61	2024-03-01	Buy
Usbiological	158336	1-[[2'-	863329-66-2	1mg	$496	2021-12-16	Buy

Product number	Packaging	Price	Buy
D4823	200mg	$122	Buy
D4823	1g	$428	Buy
18391	50mg	$32	Buy
18391	100mg	$61	Buy
158336	1mg	$496	Buy

2'-deoxy-2'-fluoro-2'-C-methyluridine Chemical Properties,Uses,Production

Description

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine / PSI-6206 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) RNA polymerase.

Uses

RO 2433 is the deaminated metabolite of β-D-2''-Deoxy-2''-fluoro-2''-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro.

Biological Activity

psi-6206 (as known as ro-2433 or gs-331007), β-d-2’-deoxy-2’-fluoro-2’-c-methyluridine, is the deaminated derivative of psi-6130, β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine, which is a potent inhibitor of hepatitis c virus (hcv) replication in the subgenomic hcv reolicon system. psi-6206, itself, does not shown any inhibitory activity towards hcv replication in the hcv subgenomic replicon system. however, the its triphosphate form, ro2433-tp, is a potent inhibitor of rna synthesis by hcv polymerase, which inhibits both the rna sysnthesis activity of hcv replicase (ic50 = 1.19 um) and the rna synthesis activity of the recombinant hcv con1 ns58 on a heteropolymeric rna template derived from the 3’-end of the negative strand of the hcv genome (ic50 = 0.52 um and ki = 0.141 um).han ma, wen-rong jiang, nicole robledo, vincent leveque, samir ali, teresa lara-jamie, mohammad masjedizadeh, david b. smith, nick cammack, klaus klumpp, and julian symons. characterization of the metabolic ctivation of hepatitis c virus nucleoside inhibitor β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine (psi-6130) and identification of a novel active 5’-triphosphate species. the journal of biological chemistry 2007; 282(41): 29812-29820

target

HCV

2'-deoxy-2'-fluoro-2'-C-methyluridine Preparation Products And Raw materials

Raw materials

Preparation Products

PSI7409 PSI 7851 Sofosbuvir

2'-deoxy-2'-fluoro-2'-C-methyluridine Suppliers

Global( 421)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58

Supplier	Advantage
airuikechemical co., ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Lianyungang happen teng technology co., LTD	58
career henan chemical co	58

View Lastest Price from 2'-deoxy-2'-fluoro-2'-C-methyluridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-08	2′-deoxy-2′-fluoro-2′-c-methyluridine 863329-66-2	US $0.00-0.00 / Kg	1Kg	99.9%	200tons	airuikechemical co., ltd.
2024-01-04	2'-deoxy-2'-fluoro-2'-C-methyluridine 863329-66-2	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2022-10-18	2'-deoxy-2'-fluoro-2'-C-methyluridine 863329-66-2	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2′-deoxy-2′-fluoro-2′-c-methyluridine
863329-66-2
US $0.00-0.00 / Kg
99.9%
airuikechemical co., ltd.

2'-deoxy-2'-fluoro-2'-C-methyluridine
863329-66-2
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

2'-deoxy-2'-fluoro-2'-C-methyluridine
863329-66-2
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

2'-deoxy-2'-fluoro-2'-C-methyluridine Spectrum

2'-deoxy-2'-fluoro-2'-C-methyluridine(863329-66-2)¹HNMR

863329-66-2(2'-deoxy-2'-fluoro-2'-C-methyluridine)Related Search:

Sofosbuvir Impurity29 PSI-7976 Sofosbuvir Impurity13 1-((2R,3R,4R,5R)-3-chloro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione SofosBuvir impurity 44

Donepezil Erythromycin thiocyanate L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester

L-Alanine isopropyl ester hydrochloride (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-uridine 3',5'-dibenzoate PSI-6130 derivative D-Arabinonic acid, 2-C-methyl-4,5-O-(1-methylethylidene)-,ethyl ester ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate

Sofosbuvir alpha-D-erythro-Pentofuranous-2-ulose 1,3,5-tribenzoate Sofosbuvir Impurity23

1of4

2'-deoxy-2'-fluoro-2'-methyluridine 1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]pyrimidine-2,4-dione 2'-deoxy-2'-fluoro-2'-C-methyluridine 2'-Deoxy-2-floro-2'Methyl-uridine 1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione PSI-6206 RO 2433 Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206 (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine 5. (2'R)-2'-Deoxy-2'-fluoro-2'-Methyluridine 2'-deoxy-2'-fluoro-2'-C-Methyluridine　(N-1) 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione RO 2433 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine Sofosbuvir Intermediate 4 Sofosbuvir INT 1 Sofosbuvir int. N-1 Sofosbuvir Nucleoside Derivative (GS-331007) Sofosbuvir Intermediates 2 (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine -fluoro-b-D-ribofuranosyl)purine -biphenyl-4-yl)methyl]-2-ethoxy-7-benzimidazolecarboxylic Acid Methyl Ester -fluoro-b-D-arabinofuranosyl)guanine -biphenyl-4-yl)methyl]-2-ethoxy-d5-7-benzimidazolecarboxylic Acid Methyl Ester -deoxy-6-methoxyguanosine -fluoro-b-D-ribofuranosyl)-2-fluoroadenine -deoxy-7-iodoadenosine -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid PSI-6206 (RO 2433) GS-331007 PSI 6206 int (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (Sofo C1) -fluoro-b-D-ribofuranosyl)-isoguanine -fluoroguanosine -chloro-b-L-arabinofuranosyl)-thymine -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester Sofosbuvir imp-11 -deoxy-O6-methylguanosine -fluoro-b-L-arabinofuranosyl)-uracil -O-trityl-b-L-arabinofuranosyl)-uracil -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid-d5 PSI-6206; RO-2433; PSI6206; RO2433 CS-832 2'-Deoxy-2'-F-2'-C-methyluridine -C-methyluridine -fluoro-beta-d-arabinofuranosyl)-5-ethyluracil -C-ethynyladenosine -fluoro-b-D-arabinofuranosyl)purine -fluoro-b-D-arabinofuranosyl)cytosine -fluoro-b-D-arabinofuranosyl)adenine -fluoro-b-D-arabinofuranosyl)-5-ethyluracil -deoxy-7-iodoguanosine -fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine -O-4-C-Methylene-b-D-ribofuranosyl)thymine -fluoro-b-D-arabinofuranosyl)cytosine HCl -fluoro-b-D-arabinofuranosyl)hypoxantine