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4-Methyl Erlotinib Hydrochloride

4-Methyl Erlotinib Hydrochloride structure

CAS No.: 1346601-52-2

Chemical Name:: 4-Methyl Erlotinib Hydrochloride

Synonyms: OSI-597;Erlotinib-9;4-methyl Erlotinib;Erlotinib iMpurity G;Erlotinib impurities406;Erlotinib 4-Methyl Analog;4-Methyl Erlotinib Hydrochloride;Azilsartan medoxomil impurity248;Erlotinib Hydrochloride iMpurity 8;N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine

CBNumber:: CB62544810

Molecular Formula:: C23H25N3O4

Molecular Weight:: 407.46

MDL Number:: MFCD32201999

MOL File:: 1346601-52-2.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:14

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4-Methyl Erlotinib Hydrochloride Properties

Melting point	224-228°C (dec.)
Boiling point	567.5±50.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), DMSO, Methanol (Slightly)
pka	5.33±0.30(Predicted)
form	Solid
color	Pale Pink to Pale Brown

4-Methyl Erlotinib Hydrochloride price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	9001510	4-methyl Erlotinib ≥95%	1346601-52-2	1mg	$81	2024-03-01	Buy
Cayman Chemical	9001510	4-methyl Erlotinib ≥95%	1346601-52-2	5mg	$356	2024-03-01	Buy
Cayman Chemical	9001510	4-methyl Erlotinib ≥95%	1346601-52-2	10mg	$632	2024-03-01	Buy
TRC	M304630	4-MethylErlotinibHydrochloride	1346601-52-2	5mg	$245	2021-12-16	Buy
TRC	M304630	4-MethylErlotinibHydrochloride	1346601-52-2	50mg	$1940	2021-12-16	Buy

Product number	Packaging	Price	Buy
9001510	1mg	$81	Buy
9001510	5mg	$356	Buy
9001510	10mg	$632	Buy
M304630	5mg	$245	Buy
M304630	50mg	$1940	Buy

4-Methyl Erlotinib Hydrochloride Chemical Properties,Uses,Production

Uses

Erlotinib (E625000) derivative as internal standard for HPLC.

Biological Activity

4-methyl erlotinib is an analog of erlotinib by the addition of a methyl group at the four position of the phenyl group. erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (egfr) [1].the epidermal growth factor receptor (egfr) autocrine pathway has been important for cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread [2].erlotinib inhibits egfr-associated kinase activity by binding to the egf-activated receptor, with the phenyl group at one end sequestered in a hydrophobic pocket of the kinase domain and the ether linkages at the opposite end projecting into solvent [1].erlotinib can prolong survival in patients with non–small-cell lung cancer after first-line or second-line chemotherapy [3].

References

[1] stamos, j. ,sliwkowski, m.x. and eigenbrot, c. structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. the journal of biological chemisty 277(48), 46265-46272 (2002).
[2] ciardiello f, tortora g. a novel approach in the treatment of cancer: targeting the epidermal growth factor receptor[j]. clinical cancer research, 2001, 7(10): 2958-2970.
[3] shepherd f a, rodrigues pereira j, ciuleanu t, et al. erlotinib in previously treated non–small-cell lung cancer[j]. new england journal of medicine, 2005, 353(2): 123-132.

4-Methyl Erlotinib Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

4-Methyl Erlotinib Hydrochloride Suppliers

Global( 50)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3149	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58
Shanghai Payne Pharmaceutical Technology Co.Ltd	021-58123769 18678586262	info@paynepharm.com	China	1354	58
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
Beijing Comparison Pharmaceutical Technology Co., Ltd	010-52878169 15701683040	sales@bjcomparison.com	China	4673	58
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632	sales@reading-chemicals.com	China	15185	58
Chengdu Miracle Pharmaceutical Co., Ltd.	028-86136736 19130631884	sales@mic-pharma.com	China	270	56
XinYao(Shenzhen) Biological Technology Co., Ltd.	0755-89880280	3004662104@qq.com	China	1830	58

Supplier	Advantage
Standardpharm Co. Ltd.	58
Hangzhou Huarong Pharm Co., Ltd.	58
sgtlifesciences pvt ltd	58
China National Standard Pharmaceutical Corporation Limited	58
Shanghai Payne Pharmaceutical Technology Co.Ltd	58
Chemsky（shanghai）International Co.,Ltd.	50
Beijing Comparison Pharmaceutical Technology Co., Ltd	58
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Chengdu Miracle Pharmaceutical Co., Ltd.	56
XinYao(Shenzhen) Biological Technology Co., Ltd.	58

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N-[(3-Ethynyl-4-Methyl)phenyl]-6,7-bis(2-Methoxyethoxy)-4-quinazolinaMine Hydrochloride OSI-597 Erlotinib iMpurity G N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride 4-Methyl Erlotinib Hydrochloride N-(3-ETHYNYL-4-METHYLPHENYL)-6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4-AMINE HCL 4-methyl Erlotinib Erlotinib 4-Methyl Analog N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine Erlotinib-9 Erlotinib Hydrochloride iMpurity 8 N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quizolin-4-aminehydrochloride Erlotinib impurity 15/N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride 4-Quinazolinamine, N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)- N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Erlotinib impurities406 Azilsartan medoxomil impurity248 Erlotinib impurity GQ: What is Erlotinib impurity G Q: What is the CAS Number of Erlotinib impurity G Q: What is the storage condition of Erlotinib impurity G 1346601-52-2 Amines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals