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Azelastine

Azelastine structure

CAS No.: 58581-89-8

Chemical Name:: Azelastine

Synonyms: -4-yl)-;AZELASTINE;SPBio_000657;KBio3_002992;CAS 790307-93-0;Azelastine base;Spectrum3_001984;Spectrum2_000649;Azeptin：Rhino1ast;Azelastine USP/EP/BP

CBNumber:: CB6256007

Molecular Formula:: C22H24ClN3O

Molecular Weight:: 381.9

MDL Number:: MFCD00242781

MOL File:: 58581-89-8.mol

Last updated:2024-03-19 15:37:50

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Azelastine Properties

Melting point	111 - 115°C
Boiling point	533.9±60.0 °C(Predicted)
Density	1.1505 (rough estimate)
refractive index	1.5790 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
pka	pKa 9.82(H2O t=25 I=0.025) (Uncertain)
form	Solid
color	White to Off-White
BCS Class	1?
Stability	Stable under recommended storage conditions., Stable Under Recommended Storage C
CAS DataBase Reference	58581-89-8(CAS DataBase Reference)
FDA UNII	ZQI909440X
ATC code	R01AC03,R06AX19,S01GX07

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H312-H302-H335-H332
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501
Toxicity	LD50 orl-rat: 310 mg/kg ARZNAD 31,1184,81

Azelastine price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A767410	Azelastine	58581-89-8	2.5g	$610	2021-12-16	Buy
TRC	A767410	Azelastine	58581-89-8	100mg	$100	2021-12-16	Buy
Biosynth Carbosynth	FC130471	4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride	58581-89-8	250mg	$145	2021-12-16	Buy
Biosynth Carbosynth	FC130471	4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride	58581-89-8	100mg	$72	2021-12-16	Buy
AK Scientific	C809	Azelastine	58581-89-8	1g	$617	2021-12-16	Buy

Product number	Packaging	Price	Buy
A767410	2.5g	$610	Buy
A767410	100mg	$100	Buy
FC130471	250mg	$145	Buy
FC130471	100mg	$72	Buy
C809	1g	$617	Buy

Azelastine Chemical Properties,Uses,Production

Description

Azelastine has potent, long-lasting histamine H1-receptor blocking activity and several other interesting anti-inflammatory properties related to its antiallergic efficacy .

Uses

anesthetic, anticonvulsant

Definition

ChEBI: A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.

brand name

Astelin (Medpointe); Optivar (Medpointe).

Clinical Use

Azelastine, although not a close structural analogue to the benzimidazoles, has some structural similarities to them. It is used as a nasal spray for allergic rhinitis and as eye drops for allergic conjunctivitis.Like olopatadine, azelastine also stabilizes mast cells, preventing degranulation and subsequent release of histamine, leukotrienes, and PGD2. It is available in Europe for systemic use in the treatment of asthma and seasonal allergies. Besides antihistaminic effects, it also may block release of histamine and other inflammatory mediators from mast cells. When administered orally, the N-dealkylated metabolite appears to contribute significantly to its pharmacological effects.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and Cl^- .

Azelastine Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID 1-Methylpyrrolidine 4-(4-Chloro-benzyl)-2H-phthalazin-1-one Hydrazine sulfate Diphenylmethane

Acetophenone

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Preparation Products

Azelastine Suppliers

Global( 148)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3791	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9553	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from Azelastine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-10	Azelastine 58581-89-8	US $0.00-0.00 / mg	10mg	90%+	10g	Guangzhou PI PI BIOTECH INC
2023-04-19	Azelastine 58581-89-8	US $50.00 / kg	1kg	99%	20 tons	Hebei Duling International Trade Co. LTD
2021-09-29	Azelastine 58581-89-8	US $0.00 / g/Bag	10g	98%min	120kg/month	WUHAN FORTUNA CHEMICAL CO., LTD

Azelastine
58581-89-8
US $0.00-0.00 / mg
90%+
Guangzhou PI PI BIOTECH INC

Azelastine
58581-89-8
US $50.00 / kg
99%
Hebei Duling International Trade Co. LTD

Azelastine
58581-89-8
US $0.00 / g/Bag
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Azelastine Spectrum

Azelastine(58581-89-8)¹HNMR

58581-89-8(Azelastine)Related Search:

METHYL THIOPHENE-2-CARBOXYLATE Methyl acetate Methylparaben Methyl acrylate 2,6-DIMETHYLNAPHTHALENE

2-Methylnaphthalene Bensulfuron methyl Thiophanate-methyl 1-AdaMantanethylaMine Kresoxim-methyl

DBU Chlorodimethylphenylsilane Triphenylphosphine Methyl Phenylacetone

Sibutramine hydrochloride Parathion-methyl AZELASTINE HCL,AZELASTINE HYDROCHLORIDE

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1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1h-azepin-4-yl)-1-(2h)-phthalazinon 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1-one 4-[(4-chlorophenyl)methyl]-2-(1-methyl-4-azepanyl)-1-phthalazinone 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one Azelastinum [INN-Latin] KBio3_002992 SPBio_000657 Spectrum2_000649 Spectrum3_001984 -4-yl)- AZELASTINE 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)- 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one CAS 790307-93-0 Azeptin：Rhino1ast 2-(Hexahydro-1-methyl-1H-azepin-4-yl)-4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one 4-(p-Chlorobenzyl)-2-(1-methylhexahydro-1H-azepin-4-yl)phthalazin-1(2H)-one 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Azelastine & Azelastine Hydrochloride Azelastine base 4-[(4-chlorophenyl)Methyl]-2-[(4S)-1-Methylazepan-4-yl]-1,2-dihydrophthalazin-1-one 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-y1)-1(2H)-phthalazinone 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2 4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methyl-4-azepanyl]-1-phthalazinone Azelastine USP/EP/BP Phenylpyruvic Acid Impurity 7 58581-89-8 53408-27-6 C22H26ClN3O TELAZOL API