CarbaMic acid, [3-[trans-5-(6-Methoxy-1-naphthalenyl)-1,3-dioxan-2-yl]propyl]-, 2-aMino-2-oxoethyl ester
- CAS No.
- 666860-59-9
- Chemical Name:
- CarbaMic acid, [3-[trans-5-(6-Methoxy-1-naphthalenyl)-1,3-dioxan-2-yl]propyl]-, 2-aMino-2-oxoethyl ester
- Synonyms
- CarbaMic acid, [3-[trans-5-(6-Methoxy-1-naphthalenyl)-1,3-dioxan-2-yl]propyl]-, 2-aMino-2-oxoethyl ester;Carbamic acid, N-[3-[trans-5-(6-methoxy-1-naphthalenyl)-1,3-dioxan-2-yl]propyl]-, 2-amino-2-oxoethyl ester
- CBNumber:
- CB62563314
- Molecular Formula:
- C21H26N2O6
- Molecular Weight:
- 402.44
- MDL Number:
- MFCD34469332
- MOL File:
- 666860-59-9.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
---|---|
Signal word | Warning |
Hazard statements | H361 |
Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
CarbaMic acid, [3-[trans-5-(6-Methoxy-1-naphthalenyl)-1,3-dioxan-2-yl]propyl]-, 2-aMino-2-oxoethyl ester Chemical Properties,Uses,Production
Biological Activity
SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor. SSR411298 has the potential for post-traumatic stress disorder research[1]. SSR411298 (0.1, 1, 10, 100, 1000, 10000 nM) inhibits mouse brain FAAH in a concentration-dependent manner[1]. SSR411298 produces maximal inhibition of FAAH between 0.3 and 30 mg/kg in the ex-vivo experiment[1]. SSR411298 (0.3, 1, 3 mg/kg; p.o.; twice a day during 2 days; 60 minutes before pretest, immediately after, and 60 minutes before the second session of testing) produces robust antidepressant-like activity in the rat forced-swimming test and in the mouse chronic mild stress model, restoring notably the development of inadequate coping responses to chronic stress in male Wistar rats weighing 235-290 g[1]. SSR411298 (0.3, 1, 3, 10 mg/kg; po; single dose; two hours prior to sacrifice) produces a significant global increase of tissular AEA, PEA and OEA levels in the hippocampus, but not of 2-AG levels[1].
References
[1]. Guy Griebel, et al. The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents. Sci Rep. 2018 Feb 5;8(1):2416.
CarbaMic acid, [3-[trans-5-(6-Methoxy-1-naphthalenyl)-1,3-dioxan-2-yl]propyl]-, 2-aMino-2-oxoethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
CarbaMic acid, [3-[trans-5-(6-Methoxy-1-naphthalenyl)-1,3-dioxan-2-yl]propyl]-, 2-aMino-2-oxoethyl ester Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 410 | 57 |
Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |
Supplier | Advantage |
---|---|
Shanghai Fuhe Chemistry Technology Co., Ltd. | 57 |
Nanjing Shizhou Biology Technology Co.,Ltd | 58 |