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Grape Seed Extract

Medicinal value of grape seed Plant Extract
Grape Seed Extract
Grape Seed Extract structure
Chemical Name:
Grape Seed Extract
GSE;GRAPE SEED;Grape skin;NataPres GS;Grape seed dry;Unii-T3pw93ib4q;Grape, red, ext.;Einecs 284-511-6;Proanthocyanidin;GRAPELEAFEXTRACT
Molecular Formula:
Formula Weight:
MOL File:

Grape Seed Extract Properties

storage temp. 
Inert atmosphere,Room Temperature
EWG's Food Scores

Grape Seed Extract Chemical Properties,Uses,Production

Medicinal value of grape seed

Grape seed have good effects on benefit “qi” and blood, strengthen the bones, diuresis, treatment of weak “qi” and blood, lung deficiency and cough, night sweats, palpitations, rheumatism, gonorrhea, and edema, etc. Modern research shows that the original anthocyanin of the grape seed extract has effects on anti-oxidation and reducing cholesterol level, making it a potential natural antioxidant. Therefore, it can be used for prevention and treatment of high cholesterol level, atherosclerosis, cataracts, stomach ulcers, intestinal adenocarcinoma, Ehrlich ascites carcinoma, etc. Its main pharmacological effects are as follows:
1. antioxidant: polyphenols of grape seed extract including proanthocyanidins and the phenolic hydroxyl of gallic acids provide specific hydrogen atoms so that they have a strong antioxidant effect. Its ability of neutralizing and attacking the Iron and oxygen in lipids is 15 to 25 times of the VB. Moreover, it has a stronger effect on scavenging free radical than VC.VE and other antioxidants.
2. anti-radiation effects: inhibit the lipid peroxidation caused by radiation.
3. anti-inflammatory effect: its main component is proanthocyanidins, whose anti-oxidation effect can inhibit the synthesis and release of histamine, serotonin, prostaglandins and leukotrienes and other inflammatory cytokines. It also inhibits the basophils and mast cells to release particles, inhibits the activity of histamine decarboxylase, and limiting the role of hyaluronidase.
4. Prevention of cataracts: Catechins is the main component for cataract prevention; grape seed extract can strengthen the myopic retinal and improve the insight of patients in a non-inflammatory form. It can also relieve the eye fatigue.
5. Anti-cancer effect: It has cytotoxicity to the MCF-7 human breast tumor cells, A-427 human lung cancer cells and human gastric adenocarcinoma cells CRL1739. It also prevents the carcinogenesis effect of intestinal chemical carcinogens.
6. Anti-atherosclerotic effect: Food containing 2.5% grape seed extract, can reduce the cholesterol ester peroxide levels in serum of experimental animal, also lower the LDL (low density lipoprotein) level against atherosclerosis. It can further improve blood rheology and platelet aggregation.
7. Cholesterol-lowering effect: Tannin gallic acid ester can reduce the levels of total plasma cholesterol, triglycerides esters, LDL cholesterol and very low density cholesterol, and increase HDL cholesterol levels.
8. Anti-ulcer effect: The oligomeric proanthocyanidins in grape seed extract can protect the gastric mucosa from damage. Proanthocyanidins can also scavenge the free radical on stomach surface and protect the gastric wall.
9. Anti-mutagenic effect: can reduce the incidence of mitochondria mutation and nuclear mutation.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Plant Extract

Grape seed extract is a plant extract, with the main ingredient, proanthocyanidins (cannot synthesized in vivo of human body), which is a novel natural anti-oxidant extracted from grape seeds. It is currently one of the most efficient plant-derived anti-oxidant. Both in vivo and in vitro tests showed that the antioxidant effect of grape seed extract is 50 times of vitamin E, 20 times stronger than vitamin C. It can effectively remove excess free radicals in the human body, thus having a superior anti-aging effect and can enhance immunity ability. The main known effects include anti-inflammatory, anti-histamine, anti-allergic, anti-allergen, anti-oxidation, anti-fatigue and improving physical fitness, improving the sub-health state and suppressing aging, treating irritability, alleviating dizziness, fatigue and hypomnesia, beauty, promoting blood circulation and so on.
In Europe, grape seed is known as "oral skin cosmetics." Grape seed is a natural sun shelter, which can keep the skin away from ultraviolet rays. The sun can kill 50% of human skin cells; but if be protected by grape seed, about 85% of the skin cells can finally survive. Owing to the special affinity of proanthocyanidins (OPC) in grape seed to the skin collagen and elastic fibers, it is possible to protect them from damage.
Grape seed extract is a main functional ingredient of cosmetics for oriental women. By inhibiting the activity of tyrosinase, it scavenges free radicals and reduces melanin deposition and skin inflammation occurrence. Thus it has the effect of convergence, tightening the skin and preventing skin wrinkle from appearing early. Long-term use can make the skin smooth and elastic with a effect of beauty.

Chemical Properties

Grape seed extract has an astrigent taste.


Grapeseed is found throughout the world.


Grapeseed may be used as an antioxidant and an anticancer treatment. It may also be used to treat varicose veins, circulatory problems, and vision problems such as cataracts, and to improve vision by lessening eye strain.


Standardized grape seed extracts are reported to contain 74 to 78% oligomeric proanthocynidins and less than approx- imately 6% of free favanol monomers on a dry weight basis Specifcally, grape seed extract contains the favanol monomers (+)-cat- echin, (–)-epicatechin, (–)-epicatechin gallate, (–)-epigallocatechin and (–)-epigallocatechin gallate.

Anticancer Research

Grape seed extract (GSE) has high quantities of proanthocyanidins and resveratrol.Human colorectal cancer cell (CRC) exposure to GSE (Schonthal 2012) resulted inmodified ER chaperones glucose-related protein-78 (GRP78) and protein disulphideisomerase (PDI). GRP78 is needed for integrity of ER as well as stress-inducedautophagy (Flaumenhaft et al. 2015). PDI, a thiol-disulphide oxidoreductase,catalyses the disulphide bonds in newly synthesized proteins in the ER lumen (Hanet al. 2013; Wang and Kaufman 2014; Perri et al. 2016), and PDIA3 is localized tothe ER and is involved in protein folding (Wang et al. 2012b). Studies on the role ofPDI in cancer have demonstrated a pro-oncogenic, pro-survival role for PDI incancer and therapeutic resistance. PDI aids in ameliorating stress-induced apoptosisand causes degradation of wrongly folded proteins (Dinicola et al. 2010; Xu et al.2014). Hence, any obstruction caused in the activity of PDI will induce stress in thecell and lead to cell apoptosis. Fructose bisphosphate aldolase, a key enzymeinvolved in glycolysis, is also a potential target of GSE (Vandewynckel et al. 2016).The ER stress leads the cell to undergo apoptotic pathways in multiple ways andhence inhibits the proliferation of the targeted cells (Farooqi et al. 2015).

Grape Seed Extract Preparation Products And Raw materials

Raw materials

Preparation Products

Grape Seed Extract Suppliers

Global( 296)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Rixing Chemical CO.,LTD
- CHINA 229 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
career henan chemical co
+86-371-86658258 CHINA 29954 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5917 58
BOC Sciences
1-631-614-7828 United States 19752 58

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View Lastest Price from Grape Seed Extract manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-09 Grape Seed Extract
US $0.00 / Kg/Bag 2Kg/Bag 95% up OPC 20 tons Sinoway Industrial co., ltd.
2021-10-29 Grape Seed Extract
US $0.00 / Kg/Drum 1KG 95%min 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-13 Grape Seed Extract
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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