ChemicalBook >> CAS DataBase List >>N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine structure

CAS No.: 477600-73-0

Chemical Name:: N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Synonyms: N-Methyl-N-[(3R,4R)-4-methyl-1-(phenylmethyl)-3-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine;N-((3R,4R)-1-BENZYL-4-METHYLPIPERIDIN-3-YL)-N-METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-;N-((3R,4R);Tofacitinib-10;Tofatinib Impurity 2;Tofacitib impurity TZ4;Tasocitinib Intermediate;Azilsartan medoxomil impurity344;-1-Benzyl-4-methylpiperidin-3-yl);Des-(N-oxopropanenitrile)-N-methylbenzyl

CBNumber:: CB62624646

Molecular Formula:: C20H25N5

Molecular Weight:: 335.45

MDL Number:: MFCD16877475

MOL File:: 477600-73-0.mol

MSDS File:: SDS

Last updated:2023-04-18 09:17:59

Request For Quotation

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Properties

Melting point	67-69℃
Density	1.205±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	13.36±0.50(Predicted)
FDA UNII	K35A6384QD

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AK Scientific	6527AB	N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine	477600-73-0	250mg	$109	2021-12-16	Buy
Matrix Scientific	125500	N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 95%	477600-73-0	250mg	$315	2021-12-16	Buy
Matrix Scientific	125500	N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 95%	477600-73-0	500mg	$595	2021-12-16	Buy
Matrix Scientific	125500	N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 95%	477600-73-0	1g	$765	2021-12-16	Buy
Ambeed	A1464808	N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 98+%	477600-73-0	25g	$1088	2021-12-16	Buy

Product number	Packaging	Price	Buy
6527AB	250mg	$109	Buy
125500	250mg	$315	Buy
125500	500mg	$595	Buy
125500	1g	$765	Buy
A1464808	25g	$1088	Buy

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Chemical Properties,Uses,Production

Uses

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is an important pharmaceutical intermediate used for the synthesis of tofacitinib. Tofacitinib is a Janus kinase (JAK) inhibitor drug used to treat rheumatoid arthritis and psoriatic arthritis.

Synthesis

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is prepared by the reaction of 4-chloropyrrolopyrimidine and (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride. The specific synthesis steps are as follows:
The reaction flask is added to sodium hydroxide (10.0g, 250mmol), water and dissolved, make 10% of the solution, adding acetone to another reaction bottle 80g, the toluene sulfonyl chloride (38.13g, 200mmol), after stirring to dissolve, then adding 4-chloro pyrrolo pyrimidine (15.36g, 100mmol), stirring mixing, cooling to 0 °C the following, dropping sodium hydroxide solution, the temperature is controlled at 5 °C the following, completion of the dropping, heating, to control the temperature to 20-30 °C stirring within the range of the reaction, to the reaction end after TLC monitoring, filtering, to get the product into the reaction bottle, adding water 200 ml, (3R, 4R)-cis-1-benzyl-4-methyl-3-methylamino-piperidine dihydrochloride (21.33g, 105mmol), stirring to dissolve, then adding potassium carbonate (82.93g, 600mmol), stirring, heating 95 °C, TLC monitoring to the reaction end of the, cooling to 45-55°C, by adding acetonitrile, preserving heat and stirring 1 hour, cooling to room temperature, crystallization, filtration, washing, the wet articles in added in the reaction bottle, adding dimethyl sulfoxide 250 ml, by adding 50% sodium hydroxide solution to 250 ml, stirring and heating 95 °C, TLC monitoring to the reaction end rear, layered, water extraction once with dimethyl sulfoxide, merger dimethyl asian sulphone level, cooling to 75-85°C, water slowly under stirring, the stirring cooling to room temperature, filtering, washing, 50% ethanol washing, filtering, drying, be [(3R, 4R) - 1 benzyl-4-methyl-piperidin-3-yl]-methyl-(7H-pyrrolo [2,3-d] pyrimidin-4-yl)-amine 25.83g, yield 77.0%, optical purity 99.8% (HPLC method).
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine synthesis

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Suppliers

Global( 170)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changsha Junyu Chemexpress.co., Ltd	+86-13723890100	info@csjyyy.cn	China	134	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1320	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81148696 +8615536356810	1047@dideu.com	China	3679	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58

Supplier	Advantage
Changsha Junyu Chemexpress.co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
career henan chemical co	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
Shanghai Yingrui Biopharma Co.,Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58

Synthesis of the 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine,N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-
7H-Pyrrolo[2,3-d]pyriMidin-4-aMine,N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-, as a heterocyclic derivative....
Apr 18，2023

View Lastest Price from N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-07-19	N-Methyl-N-[(3R,4R)-4-methyl-1-(phenylmethyl)-3-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 477600-73-0	US $3000.00 / kg	1kg	99.50%	1ton	Changsha Junyu Chemexpress.co., Ltd
2020-04-24	7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]- 477600-73-0	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2020-02-26	Tofacitinib Impurity 1 477600-73-0	US $1.00-1.00 / KG	1KG	99%+	100 tons	Shaanxi Dideu Medichem Co. Ltd

N-Methyl-N-[(3R,4R)-4-methyl-1-(phenylmethyl)-3-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
477600-73-0
US $3000.00 / kg
99.50%
Changsha Junyu Chemexpress.co., Ltd

7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-
477600-73-0
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

Tofacitinib Impurity 1
477600-73-0
US $1.00-1.00 / KG
99%+
Shaanxi Dideu Medichem Co. Ltd

477600-73-0(N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine)Related Search:

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1of4

7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]- 1H-Pyrrolo[2,3-d]pyriMidin-4-aMine,N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]- Tasocitinib Intermediate -1-Benzyl-4-methylpiperidin-3-yl) N-((3R,4R) Tofacitinib impurity 6/N-Methyl-N-[(3R,4R)-4-methyl-1-(phenylmethyl)-3-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitinib-10 (3R, 4R)-(1-benzyl-4-methyl-piperidin-3-yl) -methyl- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -amine N-[(3R,4R)-1-benzyl-4-methyl-3-piperidyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitib impurity TZ4 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]- ISO 9001：2015 REACH 1H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-methyl-N-[(3R,4R)-4-met... Azilsartan medoxomil impurity344 N-Methyl-N-[(3R,4R)-4-methyl-1-(phenylmetChemicalbookhyl)-3-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Des-(N-oxopropanenitrile)-N-methylbenzyl N-Methyl-N-[(3R,4R)-4-methyl-1-(phenylmethyl)-3-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-((3R,4R)-1-BENZYL-4-METHYLPIPERIDIN-3-YL)-N-METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN- Tofatinib Impurity 2 N-((3R,4R)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 477600-73-0 C20H25N5 API