Wnt-C59
- CAS No.
- 1243243-89-1
- Chemical Name:
- Wnt-C59
- Synonyms
- C59;CS-876;Wnt-C59;Wnt-C59 (C59);Wnt-C59, >=98%;Wnt-C59 USP/EP/BP;WNT C59; C59;WNTC59;WNT-C59 (C59);WNT C59;C59;Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem;Wnt-C59, 98%, a potent PORCN enzymatic activity and Wnt inhibitor
- CBNumber:
- CB62645245
- Molecular Formula:
- C25H21N3O
- Molecular Weight:
- 379.45
- MDL Number:
- MFCD22201167
- MOL File:
- 1243243-89-1.mol
- MSDS File:
- SDS
| Melting point | >159°C (dec.) |
|---|---|
| Boiling point | 628.3±55.0 °C(Predicted) |
| Density | 1.198±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL) |
| form | Off-white powder |
| pka | 13.78±0.70(Predicted) |
| color | Tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
Wnt-C59 price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.00496 | Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem | 1243243-89-1 | 10MG | $191 | 2024-03-01 | Buy |
| Cayman Chemical | 16644 | Wnt-C59 ≥98% | 1243243-89-1 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16644 | Wnt-C59 ≥98% | 1243243-89-1 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16644 | Wnt-C59 ≥98% | 1243243-89-1 | 10mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 16644 | Wnt-C59 ≥98% | 1243243-89-1 | 50mg | $723 | 2024-03-01 | Buy |
Wnt-C59 Chemical Properties,Uses,Production
Description
Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2? Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3? Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4
Uses
Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.
storage
-20°C
References
1) Proffitt et al. (2013), Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of Wnt-Driven Mammary Cancer; Cancer Res., 73 502 2) Koo et al. (2015), Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia; Proc. Natl. Acad. Sci.USA, 112 7548 3) Motono et al. (2016), Wnt-C59, a Small-Molecule Wnt Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells; Stem Cells Transl.Med., 5 552 4) Madan et al. (2016), Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis; Kidney Int., 89 1062
Wnt-C59 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Changzhou Xuanming Pharmaceutical Technology Co., Ltd. | +8618068519287 | sales@xuanmingchem.com | China | 820 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |