ML 133 Hydrochloride
- CAS No.
- 1222781-70-5
- Chemical Name:
- ML 133 Hydrochloride
- Synonyms
- ML133 HCl;ML 133 Hydrochloride;CID 781301 hydrochloride;VU0404943-1 hydrchloride;SID 85281105 hydrochloride;ML 133 Hydrochloride USP/EP/BP;(4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride;N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride;N-[(4-METHOXYPHENYL)METHYL]-1-NAPHTHALENEMETHANAMINE HYDROCHLORIDE;(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride
- CBNumber:
- CB62653895
- Molecular Formula:
- C19H20ClNO
- Molecular Weight:
- 313.83
- MDL Number:
- MFCD20921521
- MOL File:
- 1222781-70-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335-H400 | |||||||||
| Precautionary statements | P273-P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-37/38-41-50/53 | |||||||||
| Safety Statements | 26-39-60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
ML 133 Hydrochloride price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0190 | ML133 hydrochloride ≥95% (HPLC) | 1222781-70-5 | 5mg | $131 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0190 | ML133 hydrochloride ≥95% (HPLC) | 1222781-70-5 | 25mg | $505 | 2024-03-01 | Buy |
| Tocris | 4549 | ML133 hydrochloride ≥99%(HPLC) | 1222781-70-5 | 50 | $675 | 2021-12-16 | Buy |
| TRC | M425075 | ML133 hydrochloride | 1222781-70-5 | 250mg | $1120 | 2021-12-16 | Buy |
| Usbiological | 255843 | ML 133 hydrochloride | 1222781-70-5 | 10mg | $403 | 2021-12-16 | Buy |
ML 133 Hydrochloride Chemical Properties,Uses,Production
Uses
ML 133 is a selective inhibitor of inwardly rectifying Kir2.x potassium channels. ML 133 exhibits no effect on rKir1.1.
Uses
ML133 hydrochloride has been used as a Kir2.1 blocker to study the regulation of membrane excitability by inward-rectifier potassium channels (Kir2 family) in the dentate gyrus (DG) granule cells. It has also been used to study the effect of Kir2 on cortical neural activity.
Biological Activity
ml133 is a selective potassium channel inhibitor for kir2.1 with ic50 of 1.8 μm (ph 7.4) and 290 nm (ph 8.5), has no effect on kir1.1 and weak activity for kir4.1 and kir7.1.
Biochem/physiol Actions
ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.
storage
Store at +4°C
ML 133 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |