RGFP-966
- CAS No.
- 1357389-11-7
- Chemical Name:
- RGFP-966
- Synonyms
- CS-871;RGFP966;RGFP-966;RGFP 966;(E/Z)-RGFP 966;RGFP966, >=98%;RGFP966; RGFP-966;(2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide;2-Propenamide, N-(2-amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-, (2E)-
- CBNumber:
- CB62666682
- Molecular Formula:
- C21H19FN4O
- Molecular Weight:
- 362.4
- MDL Number:
- MFCD26960954
- MOL File:
- 1357389-11-7.mol
| Boiling point | 630.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 20 mg/ml) |
| form | solid |
| pka | 11.58±0.70(Predicted) |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
RGFP-966 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16917 | RGFP966 ≥98% | 1357389-11-7 | 1mg | $31 | 2024-03-01 | Buy |
| Cayman Chemical | 16917 | RGFP966 ≥98% | 1357389-11-7 | 5mg | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 16917 | RGFP966 ≥98% | 1357389-11-7 | 10mg | $138 | 2024-03-01 | Buy |
| TRC | R314710 | (E/Z)-RGFP966 | 1357389-11-7 | 1mg | $45 | 2021-12-16 | Buy |
| ChemScene | CS-1628 | RGFP966 99.81% | 1357389-11-7 | 10mg | $168 | 2021-12-16 | Buy |
RGFP-966 Chemical Properties,Uses,Production
Description
RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50?= 80 nM, no other HDACs inhibited @ 15μM).1?It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.1-5
Uses
(E)-RGFP 966 is a histone deacetylase 3 (HDAC3) inhibitor.
Definition
ChEBI: N-(2-amino-4-fluorophenyl)-3-[1-(3-phenylprop-2-enyl)-4-pyrazolyl]-2-propenamide is an aromatic amide and an aromatic amine.
target
HDAC3
storage
Store at -20°C
References
1) Malvaez?et al.?(2013),?HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner; Proc. Natl. Acad. Sci. USA?110?2647 2) Bieszczad?et al.?(2015),?Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation; J. Neurosci.?35?13124 3) Zhu?et al.?(2017),?HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer’s disease; Aging Cell?16?1073 4) Haiqun?et al. (2016),?The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3)in Huntington’s Disease Mice; PLoS One 0152498 5) Janczura?et al.?(2018),?Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model; Proc. Natl. Acad. Sci. USA?115?E11148
RGFP-966 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| ELSA BIOTECHNOLOGY CO.,LTD. | 15261860116 | sales@elsa-biotech.com | China | 99 | 55 |