NSC697923
- CAS No.
- 343351-67-7
- Chemical Name:
- NSC697923
- Synonyms
- NSC697923;NSC697923 USP/EP/BP;2-Nitro-5-tosylfuran;2-Nitro-5-(toluene-4-sulfonyl)-furan;2-[(4-Methylphenyl)sulfonyl]-5-nitrofur;2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran;Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-
- CBNumber:
- CB62666859
- Molecular Formula:
- C11H9NO5S
- Molecular Weight:
- 267.25786
- MDL Number:
- MFCD01925132
- MOL File:
- 343351-67-7.mol
| Melting point | 124-126°C |
|---|---|
| Boiling point | 443.8±40.0 °C(Predicted) |
| Density | 1.416±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
NSC697923 price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0618 | NSC697923 ≥98% (HPLC) | 343351-67-7 | 5mg | $46.86 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0618 | NSC697923 ≥98% (HPLC) | 343351-67-7 | 25mg | $273 | 2024-03-01 | Buy |
| Sigma-Aldrich | 662107 | UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem The UbcH13 Inhibitor, NSC697923 controls the biological activity of UbcH13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. | 343351-67-7 | 25MG | $259 | 2024-03-01 | Buy |
| Cayman Chemical | 15346 | NSC 697923 ≥98% | 343351-67-7 | 1mg | $23 | 2024-03-01 | Buy |
| Cayman Chemical | 15346 | NSC 697923 ≥98% | 343351-67-7 | 5mg | $57 | 2024-03-01 | Buy |
NSC697923 Chemical Properties,Uses,Production
Description
NSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1?Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3?Induces neuroblastoma cell death via activation of p53 and JNK.4
Uses
NSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL).
storage
+4°C
References
1) Pulvino et al.?(2012),?Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A; Blood,?120?1668 2) Strickson?et al.?(2013),?The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system; Biochem. J.,?451?427 3) Hodge?et al.?(2015),?Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting; ACS Chem. Biol.,?10?1718 4) Cheng?et al.?(2014),?A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways; Cell Death Dis.,?5?e1079
NSC697923 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| TargetMol Chemicals Inc. | 021-33632979 15002134094 | marketing@targetmol.com | China | 7934 | 58 |