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R-afatinib

R-afatinib Structure
R-afatinib structure
CAS No.
945553-91-3
Chemical Name:
R-afatinib
Synonyms
Afatinib-2;Afatinib Enantiomer;afatinib impurities139;AFATINIB CHIRAL IMPURITY;(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-;(R,E)-N-(4-((3-Chloro-4- fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinozolin- 6-yl)-4-(dimethylamino)but-2-enamide;(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetra- hydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino) but-2-enamide;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-;(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide? (Afatinib Impurity）
CBNumber:
CB62676100
Molecular Formula:
C24H25ClFN5O3
Molecular Weight:
485.94
MDL Number:
MOL File:
945553-91-3.mol
Last updated:2023-05-15 10:43:58
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R-afatinib Properties

Boiling point 676.9±55.0 °C(Predicted)
Density 1.380±0.06 g/cm3(Predicted)
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 11.79±0.43(Predicted)
color Pale Beige to Pale Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

R-afatinib price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C597485 (R)-Afatinib 945553-91-3 25mg $780 2021-12-16 Buy
Ambeed A334222 (R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide 99% 945553-91-3 1g $835 2021-12-16 Buy
A1 Biochem Labs 6566856 AfatinibImpurityC 95% 945553-91-3 250mg $1200 2021-12-16 Buy
Ambeed A334222 (R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide 99% 945553-91-3 100mg $216 2021-12-16 Buy
Ambeed A334222 (R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide 99% 945553-91-3 250mg $303 2021-12-16 Buy
Product number Packaging Price Buy
C597485 25mg $780 Buy
A334222 1g $835 Buy
6566856 250mg $1200 Buy
A334222 100mg $216 Buy
A334222 250mg $303 Buy

R-afatinib Chemical Properties,Uses,Production

Uses

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, is an impurity of Afatinib (A355300) an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

R-afatinib Preparation Products And Raw materials

Raw materials

Preparation Products

R-afatinib Suppliers

Global( 70)Suppliers
Supplier Tel Email Country ProdList Advantage
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23556 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Hangzhou Huarong Pharm Co., Ltd. 		571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3149 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11927 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Supplier Advantage
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
career henan chemical co 		58
ANHUI WITOP BIOTECH CO., LTD 		58
AFINE CHEMICALS LIMITED 		58
Hangzhou Huarong Pharm Co., Ltd. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
China National Standard Pharmaceutical Corporation Limited 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
LEAPCHEM CO., LTD. 		58

View Lastest Price from R-afatinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
R-afatinib pictures 2019-12-26 R-afatinib
945553-91-3
 US $1.00 / g 1g ≥98% g/kg/Ton Career Henan Chemical Co
  • R-afatinib pictures
  • R-afatinib
    945553-91-3
  • US $1.00 / g
  • ≥98%
  • Career Henan Chemical Co

945553-91-3(R-afatinib)Related Search:

Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine Afatinib iMpurity 4-Hydroxy 4-Dedimethylamino Afatinib
Afatinib-d6 TRANS-4-AMINOCROTONIC ACID Afatinib impurity 33 Afatinib impurity 40 Afatinib Impurity 74
Afatinib IMpurity H Afatinib Impurity L (Afatinib N-Oxide) Afatinib Impurity 22 Afatinib impurity 30 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
Afatinib impurity 27 Afatinib impurity 34 Afatinib impurity 41

1of4

2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)- (R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetra- hydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino) but-2-enamide (R,E)-N-(4-((3-Chloro-4- fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinozolin- 6-yl)-4-(dimethylamino)but-2-enamide Afatinib impurity 3/R-afatinib/(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Afatinib-2 Afatinib Enantiomer (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)- AFATINIB CHIRAL IMPURITY (R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide? (Afatinib Impurity） afatinib impurities139 945553-91-3