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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

CAS No.
394-32-1
Chemical Name:
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
Synonyms
1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE;5-FLUORO-2-HYDROXYACETOPHENONE;2-Acety-4-fluorophenol;1-(5-FLUORO-2-HYDROXY-P;2-Acetyl-4-fluorophenol;2-hydroxy-5-fluorophenone;2-HYDROXY-5-FLUOROACETOPHENONE;5'-Fluoro-2'-hydroxyacetopheno;5'-FLUORO-2'-HYDROXYACETOPHENONE;5’-fluoro-2’-hydroxy-acetophenon
CBNumber:
CB6267638
Molecular Formula:
C8H7FO2
Molecular Weight:
154.14
MDL Number:
MFCD00011668
MOL File:
394-32-1.mol
MSDS File:
SDS
Last updated:2024-03-07 16:58:36

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Properties

Melting point 56-58 °C(lit.)
Boiling point 65-66 °C8 mm Hg(lit.)
Density 1.1850 (estimate)
Flash point 65-66°C/8mm
storage temp. Inert atmosphere,Room Temperature
pka 10.17±0.18(Predicted)
form powder to crystal
color White to Gray to Brown
Water Solubility Soluble 0.68 G/L
BRN 2359087
CAS DataBase Reference 394-32-1(CAS DataBase Reference)
FDA UNII UE6FHC9K7M
NIST Chemistry Reference 5-Fluoro-2-hydroxyacetophenone(394-32-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-37/39-36/37/39
WGK Germany  3
RTECS  AM8502300
HazardClass  IRRITANT
HS Code  29147000
NFPA 704
1
2 0

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 247170 5′-Fluoro-2′-hydroxyacetophenone 98% 394-32-1 5g $31.3 2024-03-01 Buy
Sigma-Aldrich 247170 5′-Fluoro-2′-hydroxyacetophenone 394-32-1 1g $28.5 2022-05-15 Buy
TCI Chemical F0318 5'-Fluoro-2'-hydroxyacetophenone >98.0%(GC) 394-32-1 5g $35 2024-03-01 Buy
TCI Chemical F0318 5'-Fluoro-2'-hydroxyacetophenone >98.0%(GC) 394-32-1 25g $89 2024-03-01 Buy
Alfa Aesar A15614 5'-Fluoro-2'-hydroxyacetophenone, 98% 394-32-1 5g $61.7 2021-12-16 Buy
Product number Packaging Price Buy
247170 5g $31.3 Buy
247170 1g $28.5 Buy
F0318 5g $35 Buy
F0318 25g $89 Buy
A15614 5g $61.7 Buy

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties,Uses,Production

Chemical Properties

light yellow to beige-brown crystals 

Uses

5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:

  • 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
  • 3-hydroxy and 3-methoxyflavones
  • 3-hydroxy and 3-methoxy 2-styrylchromones

Definition

ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.

Preparation

Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).

General Description

5-fluoro-2-hydroxy acetophenone, also known as 2-ethanoyl-4-fluorophenol or 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone, is a kind of important medicine intermediate, can be used as multiple beta-blockers synthetic intermediate, has vast market prospect.

Synthesis

The preparation method of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone under following steps:
Performing double esterification on amino groups and phenolic hydroxy in one step by taking amino-phenol as a raw material.
Performing Fries rearrangement under the condition of aluminum chloride/sodium chloride.
Heating a hydrolyzate after completing fluorine diazotization to obtain finished 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone.

371-41-5
75-36-5
394-32-1
Synthesis of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone from 4-Fluorophenol and Acetyl chloride
Global( 373)Suppliers
Supplier Tel Email Country ProdList Advantage
Gansu Lizhong New Material Technology Co.,LTD
13088788637 19993134645 1984863666@qq.com China 7 58
Zhengzhou Anbu Chem Co.,Ltd
+8615988602810 sales@anbuchem.com China 2999 58
Shandong Juchuang Chemical Co., LTD
+86-18885615001 +86-18885615001 admin@juchuangchem.com China 387 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 7836 58
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830 figo.gao@foxmail.com China 8136 58
Accela ChemBio Inc.
(+1)-858-699-3322 info@accelachem.com United States 19965 58

View Lastest Price from 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone pictures 2024-03-11 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
394-32-1
US $399.00-251.00 / kg 500kg 99.9 200tons Shandong Juchuang Chemical Co., LTD
5'-Fluoro-2'-hydroxyacetophenone pictures 2023-12-20 5'-Fluoro-2'-hydroxyacetophenone
394-32-1
US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
1-(5-Fluoro-2-hydroxyphenyl)ethanone pictures 2023-11-25 1-(5-Fluoro-2-hydroxyphenyl)ethanone
394-32-1
US $0.00-0.00 / KG 1KG 99.40% 100 Gansu Lizhong New Material Technology Co.,LTD
2-Acetyl-4-fluorophenol 1-(5-FLUORO-2-HYDROXY-P 5-Fluoro-2-hydroxyphenyl(methyl) ketone 5'-Fluoro-2'-hydroxyacetophenone,97% 5’-fluoro-2’-hydroxy-acetophenon Ethanone, 1-(5-fluoro-2-hydroxyphenyl)- 5'-FLUORO-2'-HYDROXYACETOPHENONE 2-HYDROXY-5-FLUOROACETOPHENONE 1-(5-FLUORO-2-HYDROXY-PHENYL)ETHANONE 1-(5-FLUORO-2-HYDROXYPHENYL)-1-ETHANONE 5'-Fluoro-2'-Hydroxyacetophenone 1-(5-Fluoro-2-Hydroxyphenyl)ethan-1-one 2-Hydroxy-5-Fluoroacetophenone99% 5-Fluoro-2-hydroxyacetophenone,98% 5'-Fluoro-2'-hydroxyacetopheno 2-Acety-4-fluorophenol 5'-fluoro-2'-hydroxyacetophenone,1-(5-fluoro-2-hydroxy)ethanone 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-4-fluorophenol JRH-01009, 1-(5-Fluoro-2-hydroxyphenyl)ethanone, 97% 5'-Fluoro-2'-hydroxyacetophenone> 2-hydroxy-5-fluorophenone 5’-Fluoro-2’-hydroxyacetophenone,1-(5-Fluoro-2-hydroxyphenyl)ethanone,5‘-Fluoro-2‘-hydroxyacetophenone,5'-Fluoro-2'-hydroxyacetophenone TIANFUCHEM 394-32-1 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 5-FLUORO-2-HYDROXYACETOPHENONE 1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE 1-(5-Fluor-2-hydroxyphenyl)ethan-1-on 1-(5-fluro-2-hydroxyphenyl)ethanone 394-32-1 Building Blocks Carbonyl Compounds C7 to C8 KETONE Ketones Organic Building Blocks Aryl Fluorinated Building Blocks Building Blocks C7 to C8 C7-C8 Chemical Synthesis Fluorinated Building Blocks Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Acetophenone series Adehydes, Acetals & Ketones Fluorine Compounds Phenols C7 to C8 Carbonyl Compounds Ketones Aromatic Acetophenones & Derivatives (substituted) ketone (intermediate of nebivolol) Benzenes Alcohols and Derivatives Carbonyl Compounds 1