GSK1324726A (I-BET726)
- CAS No.
- 1300031-52-0
- Chemical Name:
- GSK1324726A (I-BET726)
- Synonyms
- GSK1324726A;CS-1736;I-BET726;I-BET726; I-BET 726;GSK1324726A (I-BET726);I-BET726 (GSK1324726A);GSK1324726A (I-BET726) USP/EP/BP;GSK-1324726A,Apoptosis,GSK1324726A,Inhibitor,Epigenetic Reader Domain,inhibit;4-(cis-1-Acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid;4-((2S,4R)-1-acetyl-4-(4-chlorophenylamino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid
- CBNumber:
- CB62677051
- Molecular Formula:
- C25H23ClN2O3
- Molecular Weight:
- 434.91
- MDL Number:
- MFCD28144683
- MOL File:
- 1300031-52-0.mol
- MSDS File:
- SDS
| Boiling point | 707.3±60.0 °C(Predicted) |
|---|---|
| Density | 1.304±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥1.87 mg/mL in EtOH with gentle warming and ultrasonic; ≥17.7 mg/mL in DMSO |
| form | Powder |
| pka | 4.20±0.10(Predicted) |
| InChIKey | FAWSUKOIROHXAP-NPMXOYFQSA-N |
| SMILES | C(O)(=O)C1=CC=C(C2C=CC3=C(C=2)[C@H](NC2=CC=C(Cl)C=C2)C[C@H](C)N3C(C)=O)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
GSK1324726A (I-BET726) price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16872 | I-BET726 ≥98% | 1300031-52-0 | 1mg | $41 | 2024-03-01 | Buy |
| Cayman Chemical | 16872 | I-BET726 ≥98% | 1300031-52-0 | 5mg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 16872 | I-BET726 ≥98% | 1300031-52-0 | 10mg | $263 | 2024-03-01 | Buy |
| Cayman Chemical | 16872 | I-BET726 ≥98% | 1300031-52-0 | 25mg | $601 | 2024-03-01 | Buy |
| ApexBio Technology | B1013 | GSK1324726A | 1300031-52-0 | 1unit | $28 | 2021-12-16 | Buy |
GSK1324726A (I-BET726) Chemical Properties,Uses,Production
Description
I-BET726 is an inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC50s = 41, 31, and 22 nM, respectively) and competes with tetra-acetylated histone 4 peptides for binding to the bromodomains of these proteins. It exhibits >1,000-fold selectivity for these proteins over other bromodomain-containing homologs. I-BET726 inhibits cell growth and induces cytotoxicity in neuroblastoma cell lines by modulating the expression of genes involved in apoptosis and Myc signaling. I-BET726 can be administered orally to animals, and it reduces tumor growth in mouse xenograft models of human neuroblastoma.
target
BRD2
References
[1] wyce a, ganji g, smitheman kn, chung cw, korenchuk s, bai y, barbash o, le b, craggs pd, mccabe mt, kennedy-wilson km, sanchez lv, gosmini rl, parr n, mchugh cf, dhanak d, prinjha rk, auger kr, tummino pj. bet inhibition silences expression of mycn and bcl2 and induces cytotoxicity in neuroblastoma tumor models. plos one. 2013 aug 23;8(8):e72967.
GSK1324726A (I-BET726) Preparation Products And Raw materials
Raw materials
Preparation Products
GSK1324726A (I-BET726) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12550 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |