GASTRIN RELEASING PEPTIDE, HUMAN

GASTRIN RELEASING PEPTIDE, HUMAN Properties

Density	1.46±0.1 g/cm3(Predicted)
storage temp.	−20°C
form	Powder
Water Solubility	Soluble to 1 mg/ml in water
Sequence	H-Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2

SAFETY

Risk and Safety Statements

WGK Germany	3

GASTRIN RELEASING PEPTIDE, HUMAN price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	G8022	Gastrin Releasing Peptide human ≥97% (HPLC)	93755-85-2	0.1mg	$146	2024-03-01	Buy
Sigma-Aldrich	G8022	Gastrin Releasing Peptide human ≥97% (HPLC)	93755-85-2	0.5mg	$477	2024-03-01	Buy
Sigma-Aldrich	G8022	Gastrin Releasing Peptide human ≥97% (HPLC)	93755-85-2	1mg	$833	2024-03-01	Buy
Tocris	1789	GRP(human)	93755-85-2	1	$298	2021-12-16	Buy
ApexBio Technology	B5171	GRP(human)	93755-85-2	5mg	$780	2021-12-16	Buy

Product number	Packaging	Price	Buy
G8022	0.1mg	$146	Buy
G8022	0.5mg	$477	Buy
G8022	1mg	$833	Buy
1789	1	$298	Buy
B5171	5mg	$780	Buy

GASTRIN RELEASING PEPTIDE, HUMAN Chemical Properties,Uses,Production

Discovery

First isolated from the porcine stomach and named gastrin-releasing peptide (GRP),1 GRP was originally believed to be a mammalian counterpart of the amphibian peptide, bombesin. Its structure has been determined in many mammals, including pigs, rats, mice, guinea pigs, dogs, and humans. In addition, GRP18–27, a possible fragment of mature GRP, was later isolated from the porcine spinal cord and originally called neuromedin C,2 although a more appropriate name is either GRP-10 or GRP18–27. GRP orthologs have been identified in birds, reptiles, amphibians, and teleost fish. On the other hand, it is reported that frogs have both GRP and bombesin, which are genetically distinct peptides, suggesting that GRP is not mammalian bombesin.
GASTRIN RELEASING PEPTIDE, HUMAN

Structure

The human GRP precursor consists of 148 aa residues (rat, 147 aa). A predicted preproGRP translation product consists of a signal peptide, GRP1–27, and a C-terminal extended peptide termed proGRP31–125. Most GRP peptides have a common sequence motif, GXHWAVGHLM amide (X=N or S), at their C-terminus. Although the N-terminal sequences are less conserved across vertebrate species, many identified GRP peptides in mammals consist of 27 aa residues, excluding rats and mice (29 aa). In nonmammals, the amphibian GRP peptide consists of 29 aa residues, the reptile peptide of 28 aa residues, and the avian peptide of 27 aa residues while the teleost peptide appears to be shorter (24–25 aa residues).
structure of human GRP precursor

Gene, mRNA, and precursor

The human GRP gene is located on chromosome 18 (18q21.32), and consists of three exons (mRNA, 850 bp long ) . Its mRNA produces a 125-aa preproGRP precursor protein. In chickens, the grp gene is located on chromosome Z. In Xenopus, the grp gene is predicted to be located on chromosome 1. In zebrafish, the grp gene is predicted to be located on chromosome 21 (CH211-233A1). GRP mRNA is produced in the CNS, stomach, intestine, pancreas, and lung in humans as well as other mammals. The expression of GRP mRNA is detected in the limbic system, including the amygdala as well as the hippocampus,8 and an overexpression in patients suffering from small cell lung cancer has been reported.

Synthesis and release

In the CNS, bombesin or GRP immunoreactivity was detected in approximately 5% of dorsal root ganglion neurons and approximately 10% of trigeminal ganglion neurons. In the brain, abundant GRP immunoreactivity was observed in the cerebral cortex, hypothalamus, and medulla oblongata. In the gastrointestinal tract, abundant GRP-immunoreactive fibers were observed in the stomach, suggesting gastrin release, and the small intestine, colon, and pancreas. In addition, the overexpression of GRP has been demonstrated at both the mRNA and protein levels in various types of tumors, including lung, prostate, breast, stomach, pancreas, and colon.

Receptors

GRPR is a GPCR superfamily with a seventransmembrane domain. GRPR is coupled to the Gq protein, and GRPR activation leads to an increase in intracellular Ca2+ and stimulation of the PLC/PKC and ERK/ MAPK pathways. In mammals, bombesin-like peptides act on a family of at least three GPCRs: the GRP-preferring receptor (GRPR), the neuromedin B-preferring receptor (NMBR), and the bombesin receptor subtype-3 (BRS-3), which is considered an orphan receptor at present. Human GRP binds GRPR (BB2 receptor) with a higher binding affinity (Ki of 1.8 - 0.4 nM) than that of NMBR (BB1 receptor) (Ki of 15 - 0.4 nM).

Agonists and Antagonists

A fragment of the C-terminal of human GRP, GRP18–27 (GRP-10), is reported to be a selective and potent agonist for GRPR. The central administration of GRP-10 induces many physiological responses, similar to that with mature GRP. RC3095 has been reported as a selective and potent antagonist of GRPR. The central administration of RC-3095 attenuates many physiological responses.

Biological functions

GRP functions via GRPR, which is highly expressed in the pancreas, and is also expressed in the stomach, adrenal cortex, and brain. Considerable evidence indicates that GRP plays a role in many physiological processes, including food intake, male sexual functions,circadian rhythms, sigh control, and fear-memory consolidation in the mammalian CNS. In addition, the itch sensation is a major biological function of GRP in mammals. In chicks, GRP functions as an anorexigenic factor in the brain.

Clinical implications

GRP and GRPR often excessively express in endocrinerelated cancer cells such as small cell lung cancer, prostate cancer, and gastrointestinal tract cancer. ProGRP is known to be a specific tumor marker for the small cell lung cancer because the half-life of proGRP in the circulation is much longer than that of GRP. GRPR is also important in prostate cancer growth and progression in an androgen-dependent manner.

Description

Gut-brain peptides are widely conserved in vertebrates, GRP is a neuropeptide that modulates the autonomic system. It is an anorexigenic factor in the brain, regulates male sexual function at the spinal cord level, conveys the itch sensation, and is also involved in many autonomic regulations in the brain. The expression of GRP is also a specific tumor marker for small cell lung cancer. It has the GXHWAVGHLM amide (X=N or S) sequence at its C-terminus.

Uses

GRP (gastrin releasing peptide) has been used for absorption/neutralization of anti-GRP antibody prior to the tyramide signal amplification (TSA) procedure.

General Description

GRP (gastrin releasing peptide) is the mammalian homolog of bombesin (BBS) and functions as a mitogen for multiple cancers, such as neuroblastoma. It is a ligand for GRPR (GRP receptor) and is expressed in a subtype of peptidergic dorsal root ganglion neurons.

Biochem/physiol Actions

GRP (gastrin releasing peptide) functions as an autocrine growth factor for nueroblastoma. It facilitates cell survival in PI3K/AKT (phosphatidylinositol-3-kinase/ v-Akt murine thymoma viral oncogene)-mediated manner and cell proliferation and angiogenesis in neuroblastoma. This peptide is involved in the release of gastrin and the control of gastric acid secretion and motor function. In patients with atopic dermatitis, the serum levels of this peptide are linked with pruritus.

Clinical Use

GRP mRNA is overexpressed in patients suffering from small cell lung cancer. Clinically, therefore, a higher level of circulating proGRP31–125 is a specific tumor marker for small cell lung cancer (higher than ~81.0 pg/mL in the plasma). In addition, intravenous infusions of GRP decrease spontaneous food intake in healthy men, suggesting GRP acts as a satiety signal in humans. GRP has not yet been used much clinically as a therapeutic agent.

storage

Store at -20°C

GASTRIN RELEASING PEPTIDE, HUMAN Preparation Products And Raw materials

Raw materials

Preparation Products

GASTRIN RELEASING PEPTIDE, HUMAN Suppliers

Global( 115)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Hangzhou Go Top Peptide Biotech	0571-88211921	sales1@gotopbio.com	CHINA	2609	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2944	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
Cellmano Biotech Limited	58
career henan chemical co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hangzhou Go Top Peptide Biotech	58
InvivoChem	58
Chengdu Youngshe Chemical Co., Ltd.	58
Nanjing TGpeptide	58
Zhejiang Hangyu API Co., Ltd	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69

View Lastest Price from GASTRIN RELEASING PEPTIDE, HUMAN manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-19	GASTRIN RELEASING PEPTIDE, HUMAN 93755-85-2	US $7.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

GASTRIN RELEASING PEPTIDE, HUMAN
93755-85-2
US $7.00 / KG
99%
Career Henan Chemical Co

GASTRIN RELEASING PEPTIDE, HUMAN Spectrum

GASTRIN RELEASING PEPTIDE, HUMAN(93755-85-2)MS

93755-85-2(GASTRIN RELEASING PEPTIDE, HUMAN)Related Search:

BIOTIN-GASTRIN RELEASING PEPTIDE, HUMAN GASTRIN RELEASING PEPTIDE (HUMAN, 18-27) (HUMAN, PORCINE, CANINE) ANTI-GASTRIN RELEASING PEPTIDE (HUMAN) GASTRIN RELEASING PEPTIDE (HUMAN, 18-27) (HUMAN, PORCINE, CANINE)2ACOH 5H2O GASTRIN RELEASING PEPTIDE, HUMAN, FAM-LABELED

GRP (HUMAN) GRP H-VAL-PRO-LEU-PRO-ALA-GLY-GLY-GLY-THR-VAL-LEU-THR-LYS-MET-TYR-PRO-ARG-GLY-ASN-HIS-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2 GASTRIN RELEASING AGENT, HUMAN GASTRIN RELEASING PEPTIDE GASTRIN RELEASING PEPTIDE, HUMAN VAL-PRO-LEU-PRO-ALA-GLY-GLY-GLY-THR-VAL-LEU-THR-LYS-MET-TYR-PRO-ARG-GLY-ASN-HIS-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2 VPLPAGGGTVLTKMYPRGNHWAVGHLM-NH2 GRP, Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2 M.W. 2859.40 C130H204N38O31S2 L-Val-L-Pro-L-Leu-L-Pro-L-Ala-Gly-Gly-Gly-L-Thr-L-Val-L-Leu-L-Thr-L-Lys-L-Met-L-Tyr-L-Pro-L-Arg-Gly-L-Asn-L-His-L-Trp-L-Ala-L-Val-Gly-L-His-L-Leu-L-Met-NH2 VAL-PRO-LEU-PRO-ALA-GLY-GLY-GLY-THR-VAL-LEU-THR-LYS-MET-TYR-PRO-ARG-GLY-ASN-HIS-TRP-ALA-VAL-GLY-HIS-LEU-MET-LYS(BIOTIN) ANTI-HSPC159 (CENTER) antibody produced in rabbit Galectin-related protein HSPC159 LGALSL GRP (human)|Gastrin Releasing Peptide, human GASTRIN RELEASING PEPTIDE HUMANGASTRIN RELEASING PEPTI Human gastrin releasing peptide (1-27) Human gastrin-releasing peptide Gastrin-releasingpeptide (human) (9CI) PubChem ID: 23185015 Gastrin releasing peptide, human, ≥97% (HPLC) L-Valyl-L-prolyl-L-leucyl-L-prolyl-L-alanylglycylglycylglycyl-L-threonyl-L-valyl-L-leucyl-L-threonyl-L-lysyl-L-methionyl-L-tyrosyl-L-prolyl-L-arginylglycyl-L-asparaginyl-L-histidyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-L-methioninamide L-Methioninamide, L-valyl-L-prolyl-L-leucyl-L-prolyl-L-alanylglycylglycylglycyl-L-threonyl-L-valyl-L-leucyl-L-threonyl-L-lysyl-L-methionyl-L-tyrosyl-L-prolyl-L-arginylglycyl-L-asparaginyl-L-histidyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl- Recombinant Human LGALSL Protein, His Tag 93755-85-2 C130H204N38O31S2 BioChemical Cancer Research Tumor Growth Regulation Tumor Promotors Neuromedins and related Peptide