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GSK2194069

GSK2194069 Structure
GSK2194069 structure
CAS No.
1332331-08-4
Chemical Name:
GSK2194069
Synonyms
GSK2194069;GSK2194069 >=97% (HPLC);GSK2194069 (GSK 2194069;4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one;(S)-4-(4-(benzofuran-5-yl)phenyl)-5-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one;3H-1,2,4-Triazol-3-one, 4-[4-(5-benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-
CBNumber:
CB62715634
Molecular Formula:
C25H24N4O3
Molecular Weight:
428.48
MDL Number:
MOL File:
1332331-08-4.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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GSK2194069 Properties

Density 1.44±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF:30.0(Max Conc. mg/mL);70.01(Max Conc. mM)
DMSO:54.28(Max Conc. mg/mL);126.68(Max Conc. mM)
Ethanol:4.91(Max Conc. mg/mL);11.46(Max Conc. mM)
pka 6.15±0.20(Predicted)
form powder
color white to light brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
NFPA 704
0
2 0

GSK2194069 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1259 GSK2194069 ≥97% (HPLC) 1332331-08-4 5MG $196 2023-06-20 Buy
Sigma-Aldrich SML1259 GSK2194069 ≥97% (HPLC) 1332331-08-4 25MG $787 2023-06-20 Buy
Cayman Chemical 20022 GSK2194069 ≥98% 1332331-08-4 500μg $32 2024-03-01 Buy
Cayman Chemical 20022 GSK2194069 ≥98% 1332331-08-4 1mg $48 2024-03-01 Buy
Cayman Chemical 20022 GSK2194069 ≥98% 1332331-08-4 5mg $169 2024-03-01 Buy
Product number Packaging Price Buy
SML1259 5MG $196 Buy
SML1259 25MG $787 Buy
20022 500μg $32 Buy
20022 1mg $48 Buy
20022 5mg $169 Buy

GSK2194069 Chemical Properties,Uses,Production

Uses

GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor.

Biochem/physiol Actions

GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC50 of 15 ± 0.5 nM.

storage

Store at +4°C

GSK2194069 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK2194069 Suppliers

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4428 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3420 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
InvivoChem 		58
Aladdin Scientific 		58
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Guangzhou Isun Pharmaceutical Co., Ltd 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
LETOPHARM LIMITED 58
Sigma-Aldrich 80
GSK2194069 4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one GSK2194069 (GSK 2194069 3H-1,2,4-Triazol-3-one, 4-[4-(5-benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro- GSK2194069 >=97% (HPLC) (S)-4-(4-(benzofuran-5-yl)phenyl)-5-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 1332331-08-4