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2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Structure
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile structure
CAS No.
1187595-85-2
Chemical Name:
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
Synonyms
2-[1-(Ethylsulfonyl)-3-azetidinylidene]acetonitrile;Baricitinib-010;Baricitinib Intermediates;Baricitinib intermediate 2;[1-(ethylsulfonyl)azetidin-3-ylidene]acetonitrile;2-(1-ETHYLSULFONY)AZETIDIN-3-YLIDENE)ACETONITRILE;(1-Ethanesulfonyl-azetidin-3-ylidene)-acetonitrile;2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile;2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile;2-[1-(ethyl sulfonyl) -3-azacyclobutyl] acetonitrile
CBNumber:
CB62715957
Molecular Formula:
C7H10N2O2S
Molecular Weight:
186.23
MDL Number:
MFCD22987586
MOL File:
1187595-85-2.mol
MSDS File:
SDS
Last updated:2023-12-29 17:45:54
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2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Properties

Melting point 67-69°C
Boiling point 360.8±52.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka -8.49±0.20(Predicted)
form Solid
color Off-White to Light Yellow
InChI InChI=1S/C7H10N2O2S/c1-2-12(10,11)9-5-7(6-9)3-4-8/h3H,2,5-6H2,1H3
InChIKey HQUIOHSYUKWGOM-UHFFFAOYSA-N
SMILES C(#N)/C=C1\CN(S(CC)(=O)=O)C\1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302+H312+H332-H315
Precautionary statements  P280-P301+P312-P362+P364
HS Code  2933998090

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC E926540 2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile 1187595-85-2 5g $275 2021-12-16 Buy
AK Scientific 3147AH 2-[1-(Ethanesulfonyl)azetidin-3-ylidene]acetonitrile 1187595-85-2 25g $206 2021-12-16 Buy
Apolloscientific OR921330 2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile 97% 1187595-85-2 25g $243 2021-12-16 Buy
ChemScene CS-M2446 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile 1187595-85-2 25g $75 2021-12-16 Buy
AK Scientific J95359 2-[1-(Ethanesulfonyl)azetidin-3-ylidene]acetonitrile 1187595-85-2 25g $160 2021-12-16 Buy
Product number Packaging Price Buy
E926540 5g $275 Buy
3147AH 25g $206 Buy
OR921330 25g $243 Buy
CS-M2446 25g $75 Buy
J95359 25g $160 Buy

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Chemical Properties,Uses,Production

Uses

2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile is an intermediate in the synthesis of Baricitinib, a JAK 1 and 2 inhibitor used in the treatment of rheumatoid arthritis.

Synthesis

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile is synthesized by first treating azetidine-3-ol hydrochloride with an equimolar equivalent of an alkanesulfonyl chloride, preferably ethanesulfonyl chloride, to give l-ethylsulfonylazetidin-3-ol. Preferably, the reaction is performed in a biphasic solution comprising a mixture of an organic phase and a aqueous phase, preferably THF with an aqueous solution which is basic, while maintaining the solution at room temperature or a temperature slightly below room temperature, preferably 20 °C. The reaction is followed to completion using standard monitoring techniques. Typically, the reaction is complete within 1 to 5 hours. The organic layer is removed, preferably by distillation, and the aqueous layer is extracted with an appropriate solvent such as toluene, p-cymene, and CPME. Preferably the extraction solvent is toluene. Alternatively, the toluene extractions can be excluded if recrystallization of 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile is performed.

synthesis route of 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile synthesis

1314910-43-4
594-44-5
1187595-85-2
Synthesis of 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile from 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) and Ethanesulfonyl chloride

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Preparation Products And Raw materials

Raw materials

2-(azetidin-3-ylidene)acetonitrile (hydrochloride) Ethanesulfonyl chloride

Preparation Products

2-(1-(ethylsulfonyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Suppliers

Global( 260)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Jinli Pharmaceutical Co.,Ltd
+86-21-57256005 +86-15921811235 chang@shjlchem.com China 20 58
Jinan Million Pharmaceutical Co., Ltd
+86-531-68659554 +8613031714605 info@millionpharm.com China 153 58
Hangzhou ICH Biofarm Co., Ltd 		+undefined8613073685410 sales@ichemie.com China 985 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 906 58
Supplier Advantage
Shanghai Jinli Pharmaceutical Co.,Ltd
58
Jinan Million Pharmaceutical Co., Ltd
58
Hangzhou ICH Biofarm Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shanghai Arbor Chemical Co., Ltd. 		58

View Lastest Price from 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile pictures 2024-04-25 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
1187595-85-2
 US $2.00 / kg 1kg 99% 1200KG/M Jinan Million Pharmaceutical Co., Ltd
2-[1-(Ethylsulfonyl)-3-azetidinylidene]acetonitrile pictures 2024-04-10 2-[1-(Ethylsulfonyl)-3-azetidinylidene]acetonitrile
1187595-85-2
 US $0.00 / kg 1kg 99% 200kg Shanghai Joiny Pharmaceutical Co.,LTD
2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile pictures 2023-12-29 2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile
1187595-85-2
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Spectrum

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile(1187595-85-2)1HNMR

1187595-85-2(2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile)Related Search:

Baricitinib 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile [1-(ethylsulfonyl)azetidin-3-ylidene]acetonitrile 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile ISO 9001：2015 REACH Baricitinib-010 2-(1-ETHYLSULFONY)AZETIDIN-3-YLIDENE)ACETONITRILE Baricitinib intermediates 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile (1-Ethanesulfonyl-azetidin-3-ylidene)-acetonitrile Acetonitrile, 2-[1-(ethylsulfonyl)-3-azetidinylidene]- 2-[1-(Ethylsulfonyl)-3-azetidinylidene]acetonitrile Baricitinib Intermediates 2- [1- (Ethylsulfonyl) -3-azacyclobutyryl] acetonitrile 2-[1-(ethyl sulfonyl) -3-azacyclobutyl] acetonitrile Baricitinib intermediate 2 1187595-85-2 1187595-85-2