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TAK-063

TAK-063 structure

CAS No.: 1238697-26-1

Chemical Name:: TAK-063

Synonyms: CS-1534;TAK-063;Balipodect;TAK 063;TAK063;TAK-063(Balipodect);TAK063, TAK 063, TAK-063, BALIPODECT;1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one;4(1H)-Pyridazinone, 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-; Pyridone 6[1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one]

CBNumber:: CB62735539

Molecular Formula:: C23H17FN6O2

Molecular Weight:: 428.42

MDL Number:: MFCD28385852

MOL File:: 1238697-26-1.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:51

Request For Quotation

TAK-063 Properties

Boiling point	612.3±65.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:55.0(Max Conc. mg/mL);128.38(Max Conc. mM)
form	A crystalline solid
pka	-0.34±0.12(Predicted)
FDA UNII	6650W303H0

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

TAK-063 price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	22208	TAK-063 ≥98%	1238697-26-1	5mg	$86	2024-03-01	Buy
Cayman Chemical	22208	TAK-063 ≥98%	1238697-26-1	10mg	$135	2024-03-01	Buy
Cayman Chemical	22208	TAK-063 ≥98%	1238697-26-1	25mg	$212	2024-03-01	Buy
Cayman Chemical	22208	TAK-063 ≥98%	1238697-26-1	50mg	$336	2024-03-01	Buy
ChemScene	CS-3551	Balipodect 98.69%	1238697-26-1	5mg	$84	2021-12-16	Buy

Product number	Packaging	Price	Buy
22208	5mg	$86	Buy
22208	10mg	$135	Buy
22208	25mg	$212	Buy
22208	50mg	$336	Buy
CS-3551	5mg	$84	Buy

TAK-063 Chemical Properties,Uses,Production

Description

TAK-063 is a potent inhibitor of phosphodiesterase 10A (PDE10A; IC₅₀ = 0.3 nM). It is >15,000-fold selective for PDE10A over other PDEs and exhibits <50% inhibition at 91 receptors, ion channels, and enzymes at a concentration of 10 μM. TAK-063 (0.3 mg/kg) increases cAMP and cGMP levels by 1.3- and 2.14-fold, respectively, in the striatum of mice. It reverses hyperlocomotion induced by PCP (Item Nos. 14276 | ISO60194) with a minimum effective dose (MED) of 0.3 mg/kg, p.o., in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg. TAK-063 also reverses hyperlocomotion induced by (+)-MK-801 (MED = 0.1 mg/kg, p.o.) but has no effect on plasma prolactin or glucose levels in rats.

TAK-063 synthesis

Synthesis of TAK-063 from Pyrazole and Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

TAK-063 Preparation Products And Raw materials

Raw materials

2-Fluoro-4-iodoaniline 1-PHENYLPYRAZOLE Pyrazole Phenylhydrazine N,N-Dimethylformamide dimethyl acetal

Preparation Products

TAK-063 Suppliers

Global( 78)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shenzhen Shengda Pharma Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58

View Lastest Price from TAK-063 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-31	Pyridone 6[1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one] 1238697-26-1	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

Pyridone 6[1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one]
1238697-26-1
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

1238697-26-1(TAK-063)Related Search:

RESATORVID TAK-960 TAK-733 Vonoprazan fumarate INK1117

TAK-063 1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one Balipodect TAK 063;TAK063 Pyridone 6[1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one] CS-1534 TAK-063(Balipodect) TAK063, TAK 063, TAK-063, BALIPODECT 4(1H)-Pyridazinone, 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)- 1238697-26-1 C23H17FN6O2 Inhibitors