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Clobetasol propionate

Mechanism of Action Indications
Clobetasol propionate
Clobetasol propionate structure
CAS No.
25122-46-7
Chemical Name:
Clobetasol propionate
Synonyms
Olux;Psorex;Olux-E;Clobex;cgp9555;GR-2/92;Karison;Temovate;CCl 4725;Dermoval
CBNumber:
CB6274337
Molecular Formula:
C25H32ClFO5
Formula Weight:
466.97
MOL File:
25122-46-7.mol

Clobetasol propionate Properties

Melting point:
195.5-1970C
Boiling point:
569.0±50.0 °C(Predicted)
alpha 
D +103.8° (c = 1.04 in dioxane)
Density 
1.1653 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent).
form 
neat
pka
12.88±0.70(Predicted)
InChIKey
CBGUOGMQLZIXBE-XGQKBEPLSA-N
CAS DataBase Reference
25122-46-7(CAS DataBase Reference)
FDA UNII
779619577M
Proposition 65 List
Clobetasol Propionate
NCI Drug Dictionary
clobetasol propionate
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS07
Signal word  Danger
Hazard statements  H360Df-H373-H413-H315-H319
Precautionary statements  P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P201-P260-P280-P308+P313
Hazard Codes  Xi,T
Risk Statements  36/37/38-62-53-48/20/21-61
Safety Statements  26-36-45-36/37-53
WGK Germany  2
RTECS  TU3725000
HS Code  29372290

Clobetasol propionate price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C8037 Clobetasol propionate analytical standard 25122-46-7 1g $289 2021-12-16 Buy
Sigma-Aldrich 1138405 Clobetasol propionate United States Pharmacopeia (USP) Reference Standard 25122-46-7 200mg $366 2021-12-16 Buy
Cayman Chemical 21251 Clobetasol Propionate ≥98% 25122-46-7 500mg $28 2021-12-16 Buy
Cayman Chemical 21251 Clobetasol Propionate ≥98% 25122-46-7 1g $50 2021-12-16 Buy
TRC C583500 Clobetasol17-Propionate 25122-46-7 250mg $130 2021-12-16 Buy

Clobetasol propionate Chemical Properties,Uses,Production

Mechanism of Action

Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.

Indications

Clobetasol propionate is the 17-O-propionate ester of clobetasol and it derives from a clobetasol and a propionic acid. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.
Clobetasol propionate was patented in 1968 and came into medical use in 1978. It is available as a generic medication. Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis, psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases, including alopecia areata, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.

Chemical Properties

White or almost white, crystalline powder.

Originator

Dermovate,Glaxo,UK,1973

Uses

Clobetasol-17-propionate is a topical corticosteroid belonging to the group-D (hydrocortisone-q-butyrate) type of steroids.

Uses

For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.

Uses

Topical corticosteroid. Glucocorticoid; anti-inflammatory.
Clobetasol Propionate
Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.

Definition

ChEBI: The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.

Indications

Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.

Manufacturing Process

A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide (25 ml) was treated with lithium chloride (4 g) and the mixture heated on the steam bath for 30 minutes. Dilution with water gave the crude product which was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by reaction with propionic anhydride.

brand name

Clobex (Galderma); Clobex (Galderma); Embeline (Healthpoint); Olux (Connetics); Temovate (Altana).

Therapeutic Function

Corticosteroid, Antiinflammatory

Clobetasol propionate Preparation Products And Raw materials

Raw materials

Preparation Products


Clobetasol propionate Suppliers

Global( 503)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Baoji Guokang Healthchem co.,ltd
09178656283
cngksw@aliyun.com CHINA 9466 58
Connect Chemicals GmbH
+49 2102 2077-39
+49 2102 2077-40 inquiries@connectchemicals.com Germany 265 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2940 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58

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View Lastest Price from Clobetasol propionate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-20 Clobetasol propionate
25122-46-7
US $1.00 / g 10g 99.5% 1000kg Guangzhou Biocar Biotechnology Co.,Ltd.
2022-01-20 Clobetasol propionate
25122-46-7
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2022-01-19 Clobetasol propionate
25122-46-7
US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.

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