TP0903
- CAS No.
- 1341200-45-0
- Chemical Name:
- TP0903
- Synonyms
- TP0903;TP-0903;CS-1642;Dubermatinib;Apraclonidina;TP 0903;TP0903;Apraclonidinum;Dubermatinib(TP-0903);TP-0903(Dubermatinib);2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide
- CBNumber:
- CB62745451
- Molecular Formula:
- C24H30ClN7O2S
- Molecular Weight:
- 516.06
- MDL Number:
- MFCD28502172
- MOL File:
- 1341200-45-0.mol
| Melting point | >198°C (dec.) |
|---|---|
| Boiling point | 664.7±65.0 °C(Predicted) |
| Density | 1.347±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 7.60±0.10(Predicted) |
| form | Solid |
| color | Off-White to Light Yellow |
| FDA UNII | 14D65TV20J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
TP0903 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28757 | TP-0903 | 1341200-45-0 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 28757 | TP-0903 | 1341200-45-0 | 25mg | $593 | 2024-03-01 | Buy |
| Cayman Chemical | 28757 | TP-0903 | 1341200-45-0 | 5mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 28757 | TP-0903 | 1341200-45-0 | 10mg | $270 | 2024-03-01 | Buy |
| TRC | T700300 | TP-0903 | 1341200-45-0 | 2.5mg | $55 | 2021-12-16 | Buy |
TP0903 Chemical Properties,Uses,Production
Uses
TP-0903 is an AXL kinase inhibitor.
Biological Activity
axl and other tam family members are known to be involved in maintaining the mesenchymal phenotype in cancer cells. mesenchymal cells have increased invasion and migratory properties, enhanced cell survival in stressed environments, as well as increased resistance to targeted therapies. tp-0903 is a potent anti-cancer agent targeting the axl receptor tyrosine kinase.
in vitro
on the basis of the potency of tp-0903 in biochemical assays, its activity in cell-based studies was evaluated. tp-0903 showed extremely potent activity in cell viability assays against the pancreatic cancer cell line psn-1. more importantly, tp-0903 was evaluated for its ability to block gas6-mediated activation of axl in pancreatic cancer cells. psn-1 cells were serum-starved and then stimulated with gas6 in the presence of various concentrations of tp-0903 [1].
in vivo
tp-0903 restores sensitivity to erlotinib in cell-based and preclinical animal models of cancer by reversing the mesenchymal phenotype driving resistance [2].
IC 50
0.027 μm against axl
References
[1] mollard a, warner sl, call lt, wade ml, bearss jj, verma a, sharma s, vankayalapati h, bearss dj. design, synthesis and biological evaluation of a series of novel axl kinase inhibitors. acs med chem lett. 2011 dec 8;2(12):907-912.
[2] toleropharmaceuticals, inc–tp-0903. http://www.toleropharmaceuticals.com/tp-0903.html.
TP0903 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
View Lastest Price from TP0903 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-31 | 2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide
1341200-45-0
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- 2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide
1341200-45-0
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co