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Spermine

CAS No.
71-44-3
Chemical Name:
Spermine
Synonyms
SPERMINE TETRAHYDROCHLORIDE;Spermin;NEURIDINE HYDROCHLORIDE;MUSCULAMINE HYDROCHLORIDE;DJtPAT;Spermine;NSC 268508;Spermine,97%;Spermine >98%;SOYASAPONIN IV(SH)
CBNumber:
CB6275334
Molecular Formula:
C10H26N4
Molecular Weight:
202.34
MDL Number:
MFCD00012914
MOL File:
71-44-3.mol
MSDS File:
SDS
Last updated:2023-12-29 14:48:20

Spermine Properties

Melting point 28-30 (lit.)
Boiling point 150 °C/5 mmHg (lit.)
Density 0.937
refractive index 1.4850 (estimate)
Flash point >230 °F
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form powder
pka 10.88±0.19(Predicted)
Water Solubility Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.
Sensitive Air Sensitive & Hygroscopic
Merck 14,8743
BRN 1751791
Stability Hygroscopic
InChIKey PFNFFQXMRSDOHW-UHFFFAOYSA-N
LogP -0.543 (est)
CAS DataBase Reference 71-44-3(CAS DataBase Reference)
FDA UNII 2FZ7Y3VOQX
NIST Chemistry Reference Spermine(71-44-3)
EPA Substance Registry System 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H318-H314
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P305+P351+P338-P310
Hazard Codes  Xi,C
Risk Statements  36/38-34
Safety Statements  26-36-45-36/37/39-27
RIDADR  UN 3259 8/PG 2
WGK Germany  3
RTECS  EJ7230000
3-10
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29212900
NFPA 704
1
3 1

Spermine price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 85590 Spermine ≥99.0% (GC) 71-44-3 5g $321 2024-03-01 Buy
Sigma-Aldrich 55513 Spermine analytical standard 71-44-3 100mg $73.6 2024-03-01 Buy
Alfa Aesar L19562 Spermine, 97% 71-44-3 1g $58.9 2024-03-01 Buy
Alfa Aesar L19562 Spermine, 97% 71-44-3 5g $188 2024-03-01 Buy
Cayman Chemical 18041 Spermine ≥95% 71-44-3 1g $37 2024-03-01 Buy
Product number Packaging Price Buy
85590 5g $321 Buy
55513 100mg $73.6 Buy
L19562 1g $58.9 Buy
L19562 5g $188 Buy
18041 1g $37 Buy

Spermine Chemical Properties,Uses,Production

Description

Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.

Chemical Properties

White to slightly off-white powder crysta

Uses

immune modulator

Uses

Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes

Uses

Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).

Definition

ChEBI: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.

General Description

Spermine?is a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.

Biochem/physiol Actions

Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

storage

+4°C (desiccate)

References

[1] fakler b, brndle u, glowatzki e, et al. strong voltage-dependent inward rectification of inward rectifier k+ channels is caused by intracellular spermine[j]. cell, 1995, 80(1): 149-154.
[2] til h p, falke h e, prinsen m k, et al. acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[j]. food and chemical toxicology, 1997, 35(3): 337-348.

Spermine Preparation Products And Raw materials

Global( 308)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou Zelixir Biotech Co., Ltd.
+8618867646786 neal.chen@zelixir.com China 228 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Shaanxi Haibo Biotechnology Co., Ltd
+86-02963020060 +86-18629295024 hibo06@xaltbio.com China 1000 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830 figo.gao@foxmail.com China 8136 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58

View Lastest Price from Spermine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Spermine pictures 2024-03-27 Spermine
71-44-3
US $0.00-0.00 / kg 0.1kg 99.5% 1000 Hangzhou Zelixir Biotech Co., Ltd.
Spermine pictures 2023-11-16 Spermine
71-44-3
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Spermine pictures 2023-11-08 Spermine
71-44-3
US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
  • Spermine pictures
  • Spermine
    71-44-3
  • US $0.00-0.00 / kg
  • 99.5%
  • Hangzhou Zelixir Biotech Co., Ltd.
  • Spermine pictures
  • Spermine
    71-44-3
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Spermine pictures
  • Spermine
    71-44-3
  • US $0.00 / kg
  • 99%
  • Shaanxi Haibo Biotechnology Co., Ltd
SPERMINE HYDROCHLORIDE n,n’-bis(3-aminopropyl)-4-butanediamine n,n’-bis(3-aminopropyl)-4-diaminobutane N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE 4 H CL N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TETRAHYDROCHLORIDE N,N'-BIS-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE TETRAHYDROCHLORIDE N,N'-BIS(3-AMINOPROPYL)-BUTANE-1,4-DIAMINE TETRAHYDROCHLORIDE NEURIDINE TETRAHYDROCHLORIDE MUSCULAMINE TETRAHYDROCHLORIDE Spermine SOYASAPONIN IV(SH) Spermine,N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine Spermine >98% N,N'-Bis(3-aminopropyl)-1,4-butanediamine N1,N1'-(butane-1,4-diyl)bis(propane-1,3-diaMine) GERONTINE TETRAHYDROCHLORIDE DIAMINOPROPYLTETRAMETHYLENEDIAMINE HYDROCHLORIDE 1,4-BIS(AMINOPROPYL)BUTANEDIAMINE TETRAHYDROCHLORIDE 4,9-diazadodecamethylenediamine N,N-Bis(3-aminopropyl)-1,4-diaminobutane~Gerontine~Musculamine~Neuridine Spermine N,N-Bis(3-aminopropyl)-1,4-diaminobutane SPERMINE FREE BASE CELL CULTURE TESTED Spermine,97% Sperminedihydrate,97% BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE NSC 268508 SPERMINE FREE BASE extrapure 1,4-Bis(aminopropyl)butanediamine 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- 1,4-Diaminobutane, N,N'-bis(3-aminopropyl)- 4,9-Diaza-1,12-dodecanediamine 4,9-Diazadodecane-1,12-diamine N,NBis(2-aminopropyl)-1,4-butane-diamine, N,NBis(2-aminopropyl)tetramethylenediamine SPERMINE >= 99.0% (GC) bis(propane-1,3-diamine) N1,N1'-(Butane-1,4-diyl) 1,4-Butanediamine, N1,N4-bis(3-aminopropyl)- DJtPAT Spermine CAS 71-44-3 with Best Price Fast Delivery Good Quality Spermine (NSC-268508 (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl}) amine Spermine, ≥99% (GC) SPERMINE TETRAHYDROCHLORIDE Spermin NEURIDINE HYDROCHLORIDE MUSCULAMINE HYDROCHLORIDE 71-44-3 77-44-3 H2NCH23NHCH23NH2 NH2CH23NHCH24NHCH23NH2 H2NCNHNHCH24NH2 C10H26N4 Amino Acids and Peptides Biochemicals and Reagents BioChemical Application Index BioChemika Ultra Cell Signaling Enzymes