CYCLOSPORIN D
- CAS No.
- 63775-96-2
- Chemical Name:
- CYCLOSPORIN D
- Synonyms
- CS-1740;Ring spore D;CYCLOSPORIN D;Val2-cyclosporine;Cyclosporin D, >=95%;Cyclosporin D solution;cyclosporin impurity D;7-L-Valinecyclosporin A;Cyclosporine IMpurity-D;Cyclosporine Impurity 4
- CBNumber:
- CB6276179
- Molecular Formula:
- C63H113N11O12
- Molecular Weight:
- 1216.64
- MDL Number:
- MFCD11111526
- MOL File:
- 63775-96-2.mol
Melting point | 148-1510C |
---|---|
alpha | D20 -245° (c = 0.52 in CHCl3); D20 -211° (c = 0.51 in methanol) |
Boiling point | 1294.7±65.0 °C(Predicted) |
Density | 1.015±0.06 g/cm3(Predicted) |
Flash point | 9 °C |
storage temp. | -20°C Freezer |
solubility | Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly) |
form | Colorless to off-white crystalline solid. |
pka | 13.22±0.70(Predicted) |
color | White to Off-White |
InChIKey | YJDYDFNKCBANTM-QCWCSKBGSA-N |
FDA UNII | 8ZD3I5M2HF |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS07 |
---|---|
Signal word | Danger |
Hazard statements | H225-H302+H312+H332-H319 |
Precautionary statements | P210-P280-P305+P351+P338 |
Hazard Codes | F,Xn,T |
Risk Statements | 11-20/21/22-36-39/23/24/25-23/24/25 |
Safety Statements | 16-36/37-45-7 |
RIDADR | UN 1648 3 / PGII |
WGK Germany | 2 |
HS Code | 29419090 |
CYCLOSPORIN D price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C-108 | Cyclosporin D solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | 63775-96-2 | 1mL | $288 | 2024-03-01 | Buy |
Cayman Chemical | 15477 | Cyclosporin D ≥95% | 63775-96-2 | 1mg | $106 | 2024-03-01 | Buy |
Cayman Chemical | 15477 | Cyclosporin D ≥95% | 63775-96-2 | 5mg | $239 | 2024-03-01 | Buy |
TRC | C988910 | CyclosporinD | 63775-96-2 | 50mg | $870 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC20756 | Cyclosporin D | 63775-96-2 | 25mg | $412.5 | 2021-12-16 | Buy |
CYCLOSPORIN D Chemical Properties,Uses,Production
Chemical Properties
Colorless Crystalline Solid
Uses
A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
Uses
Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.
Biological Activity
cyclosporin d is an immunosuppressive agent [1].cyclosporin d (csd) is an analogue of cyclosporine a with weak immunosuppressive activity. cyclosporin d has been used as an internal standard for the quantification of cyclosporin a. in human multidrug-resistant ovarian cancer cells, cyclosporin d significantly overcame adriamycin resistance [2]. in lymphocyte, csd weakly inhibited pha-, pwm-, and pma + ca2+-induced cell proliferation [3].in mice, csd inhibited edema in mouse ear and alkaline phosphatase activity in mouse skin induced by tpa by 98% and 88%, respectively. in cytosol of mouse pancreas, csd inhibited the ca2+/calmodulin-dependent phosphorylation of the elongation factor 2 (ef-2) and the tpa-induced increase of ef-2 [1]. cyclosporin d was effective in inhibiting p. falciparum parasite in vitro and p. berghei malaria parasite development in vivo when administered orally [4].
storage
+4°C
References
[1]. gschwendt m, kittstein w, marks f. the weak immunosuppressant cyclosporine d as well as the immunologically inactive cyclosporine h are potent inhibitors in vivo of phorbol ester tpa-induced biological effects in mouse skin and of ca2+/calmodulin dependent ef-2 phosphorylation in vitro. biochem biophys res commun, 1988, 150(2): 545-551.
[2]. mizuno k, furuhashi y, misawa t, et al. modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, fk506 and mizoribine. anticancer res, 1992, 12(1): 21-25.
[3]. sadeg n, pham-huy c, rucay p, et al. in vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines a, c, d and metabolites m1, m17 and m21. immunopharmacol immunotoxicol, 1993, 15(2-3): 163-177.
[4]. uadia po1, ezeamuzie ic, ladan mj, et al. antimalarial activity of cyclosporins a, c and d. afr j med med sci, 1994, 23(1): 47-51.
CYCLOSPORIN D Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9294 | 55 |
Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29822 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
View Lastest Price from CYCLOSPORIN D manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-02-25 | Val2-Cyclosporine
63775-96-2
|
US $128.00 / KG | 1KG | 99% | 1 ton | Hong Kong Tiansheng New Material Trading Co., Ltd | ||
2022-02-25 | Val2-Cyclosporine | US $3.21 / Kg/Bag | 1KG | 99% | 20tons | Hong Kong Tiansheng New Material Trading Co., Ltd | ||
2020-01-03 | CYCLOSPORIN D
63775-96-2
|
US $1.00 / KG | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
- Val2-Cyclosporine
63775-96-2
- US $128.00 / KG
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
- Val2-Cyclosporine
- US $3.21 / Kg/Bag
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
- CYCLOSPORIN D
63775-96-2
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co
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