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LORMETAZEPAM

LORMETAZEPAM structure

CAS No.: 848-75-9

Chemical Name:: LORMETAZEPAM

Synonyms: Loramet;WY-4082;Ergocalm;Noctamid;RO 5-5516;LORMETAZEPAM;lormethazepam;METHYLLORAZEPAM;N-Methyllorazepam;(RS)-Lormetazepam

CBNumber:: CB6277893

Molecular Formula:: C16H12Cl2N2O2

Molecular Weight:: 335.18

MDL Number:: MFCD00058578

MOL File:: 848-75-9.mol

Last updated:2023-05-15 10:44:01

LORMETAZEPAM Properties

Melting point	163-168°C
Boiling point	575.8±50.0 °C(Predicted)
Density	1.4463 (rough estimate)
refractive index	1.6100 (estimate)
Flash point	9℃
storage temp.	Controlled Substance, -20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	11.60±0.40(Predicted)
color	Pale Yellow to Pale Green
EWG's Food Scores	1
FDA UNII	GU56C842ZA
ATC code	N05CD06

Pharmacokinetic data

Protein binding	85%
Excreted unchanged in urine	<6 (86 as metabolites)
Volume of distribution	4.6(L/kg)
Biological half-life	11-16 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS02,GHS06,GHS08
Signal word	Danger
Hazard statements	H225-H301+H311+H331-H370
Precautionary statements	P210-P260-P280-P301+P310-P311
Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25-22
Safety Statements	7-16-36/37-45-36
RIDADR	3249
WGK Germany	1
HazardClass	6.1(b)
PackingGroup	III

LORMETAZEPAM Chemical Properties,Uses,Production

Chemical Properties

Pale Green Solid

Originator

Loramet ,Wyeth, W. Germany,1980

Uses

An analog of Lorazepam (L469850). Sedative, hypnotic. Controlled substance (depressant).

Definition

ChEBI: Lormetazepam is a 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position. It has a role as a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound.

Manufacturing Process

To a suspension of 3.4 g of 3-acetoxy-7-chloro-1,3-dihydro-5-(ochlorophenyl)-2H-1,4-benzodiazepin-2-one in 80 ml of alcohol was added 6 ml of 4 N sodium hydroxide. After complete solution had taken place a solid precipitated that redissolved upon the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals. After recrystallization from alcohol the compound melted at 192°C to 194°C.

Therapeutic Function

Hypnotic

LORMETAZEPAM Preparation Products And Raw materials

Raw materials

Sodium hydroxide

Preparation Products

848-75-9(LORMETAZEPAM)Related Search:

MEDAZEPAM Benzophenone imine OXAZEPAM 4-CHLORO-O-TOLUIDINE HYDROCHLORIDE 2-(O-TOLYLAMINO)ETHANOL

Nordazepam Lorazepam LORMETAZEPAM Diazapam 1,3-Dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiozepin-2-one

Delorazepam 1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one TEMAZEPAM 2-HYDROXY-N-METHYL-N-PHENYL-ACETAMIDE 4-CHLORO-N-METHYLFORMANILIDE

1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE BENZHYDRYLIDENE METHYLAMINE (R)-Lormetazepam

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2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1-methyl- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl- 2h-1,4-benzodiazepin-2-one,1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1 2h-1,4-benzodiazepin-2-one,7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1h-1,4-benzodiaze 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one Ergocalm Loramet N-Methyllorazepam Noctamid RO 5-5516 WY-4082 METHYLLORAZEPAM LORMETAZEPAM Lormetazepam solution LORMETAZEPAM METHANOL SOLUTION (RS)-Lormetazepam 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl- (9CI) 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl- (7CI, 8CI) 7-Chloro-1,3-dihydro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one lormethazepam 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one Lormetazepam Solution, 100ppm LORMETAZEPAM USP/EP/BP 848-75-9 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals