Methyl 2-aminonicotinate
- CAS No.
- 14667-47-1
- Chemical Name:
- Methyl 2-aminonicotinate
- Synonyms
- 2-AMINO-NICOTINIC ACID METHYL ESTER;RARECHEM AL BF 1234;Methyl 2-aminonicoti;Methyl 2-aminonicotite;METHYL 2-AMINONICOTINATE;2- aMinoMethyl nicotinate;Methyl2-Aminonicotinate>Methyl2-aminonicotinate,97%;Methyl 2-aMinonicotinate, >95%;Methyl 2-aminopyridin-3-carboxylate
- CBNumber:
- CB6279529
- Molecular Formula:
- C7H8N2O2
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD00128872
- MOL File:
- 14667-47-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 2-aminopyridine-3-carboxylate 97% | 715107 | 5g | $171 |
| Methyl 2-aminopyridine-3-carboxylate 97% | 715107 | 1g | $81 |
| Methyl 2-Aminonicotinate >97.0%(GC)(T) | M2125 | 1g | $24 |
| Methyl 2-Aminonicotinate >97.0%(GC)(T) | M2125 | 5g | $64 |
| Methyl 2-Aminonicotinate | M286995 | 1g | $70 |
| More product size | |||
| Melting point | 82-86 °C |
|---|---|
| Boiling point | 251.3±20.0 °C(Predicted) |
| Density | 1.238±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 4.71±0.36(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C7H8N2O2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3,(H2,8,9) |
| InChIKey | NZZDEODTCXHCRS-UHFFFAOYSA-N |
| SMILES | C1(N)=NC=CC=C1C(OC)=O |
| CAS DataBase Reference | 14667-47-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Methyl 2-aminonicotinate price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 715107 | Methyl 2-aminopyridine-3-carboxylate 97% | 14667-47-1 | 5g | $171 | 2026-03-19 | Buy |
| Sigma-Aldrich | 715107 | Methyl 2-aminopyridine-3-carboxylate 97% | 14667-47-1 | 1g | $81 | 2023-06-20 | Buy |
| TCI Chemical | M2125 | Methyl 2-Aminonicotinate >97.0%(GC)(T) | 14667-47-1 | 1g | $24 | 2026-03-19 | Buy |
| TCI Chemical | M2125 | Methyl 2-Aminonicotinate >97.0%(GC)(T) | 14667-47-1 | 5g | $64 | 2026-03-19 | Buy |
| TRC | M286995 | Methyl 2-Aminonicotinate | 14667-47-1 | 1g | $70 | 2021-12-16 | Buy |
Methyl 2-aminonicotinate Chemical Properties,Uses,Production
Chemical Properties
Off white powder
Uses
Methyl 2-Aminonicotinate is used to prepare 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827)as a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. It is also used to synthesize quinazolinone/quinazoline thione derivatives as phosphodiesterase 7 inhibitors.
Materials Uses
With the help of specific reactions, methyl 2-aminonicotinate can be introduced into the structure of polymer materials, endowing materials with special properties, such as improving the stability, solubility, and even giving them some functional response characteristics, which opens up new avenues for the development of materials science.
Synthesis
67-56-1
5345-47-1
14667-47-1
Concentrated sulfuric acid (96%, 144 mL, 2.69 mol, 18.6 eq.) was slowly added dropwise to a stirred suspension of 2-aminonicotinic acid (20.0 g, 0.145 mol) in methanol (228 mL, 7.12 mol, 49.2 eq.), and the reaction system was kept at 0 °C. Subsequently, the reaction mixture was irradiated in a microwave reactor (power input 300 W) at 60 °C and atmospheric pressure for 1.5 hours. Upon completion of the reaction, the light brown mixture was carefully poured into ice water, maintained at 0 °C, and solid sodium carbonate was added by batchwise addition until complete neutralization (pH > 8). The aqueous layer was extracted three times with ethyl acetate. The organic layers were combined, washed sequentially with saturated brine and deionized water, and then dried with anhydrous magnesium sulfate. Finally, the organic solvent was evaporated to afford methyl 2-aminopyridine-3-carboxylate (21.15 g, 93% yield) as colorless needle-like crystals with purity meeting the analytical requirements.
References
[1] Tetrahedron, 2014, vol. 70, # 35, p. 5541 - 5549
[2] European Journal of Medicinal Chemistry, 2012, vol. 52, p. 284 - 294
[3] Synthetic Communications, 2006, vol. 36, # 2, p. 181 - 186
[4] Patent: WO2005/32481, 2005, A2. Location in patent: Page/Page column 38
Methyl 2-aminonicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Shandong Liteng Biotechnology Co. , Ltd. | +86-18663721413 +86-15552573001 | rosy@litengpharm.com | China | 3280 | 58 |
| Shijiazhuang Dowell Chemical Co.,Ltd | +8618633820607 | sell@dowechem.com | China | 89 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29820 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2949 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
View Lastest Price from Methyl 2-aminonicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-29 | Methyl 2-aminonicotinate
14667-47-1
|
US $5.00 / kg | 1kg | ≥98% | 100mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2025-06-25 | Methyl 2-aminonicotinate
14667-47-1
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-04 | Methyl 2-aminonicotinate
14667-47-1
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- Methyl 2-aminonicotinate
14667-47-1
- US $5.00 / kg
- ≥98%
- Jinan Finer Chemical Co., Ltd
-
- Methyl 2-aminonicotinate
14667-47-1
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Methyl 2-aminonicotinate
14667-47-1
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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