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Caffeic acid

Physical and Chemical Properties Extraction Method Drugs for white blood cells increase HPLC determination of caffeic acid in dandelion Chemical Properties Uses Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Caffeic acid
Caffeic acid
Chemical Name:
Caffeic acid
Caffeic;NSC 623438;CAFFIC ACID;CAFFEIC ACID;AKOS B004050;Caffeic acid 0;Caffeicacid,96%;CaffeicAcidPure;3,4-dihydroxyben;CAFFEICACID(BULK
Molecular Formula:
Formula Weight:
MOL File:

Caffeic acid Properties

Melting point:
211-213 °C (dec.)(lit.)
Boiling point:
272.96°C (rough estimate)
1.2933 (rough estimate)
refractive index 
1.4500 (estimate)
storage temp. 
Store at RT.
ethanol: 50 mg/mL
yellow to tan
Water Solubility 
soluble in hot water
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference
331-39-5(CAS DataBase Reference)
NIST Chemistry Reference
Cinnamic acid, 3,4-dihydroxy-(331-39-5)
EPA Substance Registry System
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-(331-39-5)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-40-63-68
Safety Statements  26-36/37/39-36
WGK Germany  3
RTECS  GD8950000
Hazard Note  Irritant
HS Code  29182990
Hazardous Substances Data 331-39-5(Hazardous Substances Data)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Caffeic acid price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 205546 Caffeic Acid 331-39-5 500mg $75.2 2018-11-20 Buy
Sigma-Aldrich 60018 Caffeic acid matrix substance for MALDI-MS, ≥99.0% (HPLC) 331-39-5 1g $91.1 2018-11-13 Buy
TCI Chemical C0002 Caffeic Acid >98.0%(T) 331-39-5 5g $27 2018-11-22 Buy
TCI Chemical C0002 Caffeic Acid >98.0%(T) 331-39-5 25g $90 2018-11-22 Buy
Alfa Aesar A15950 3,4-Dihydroxycinnamic acid, predominantly trans, 98+% 331-39-5 10g $55.1 2018-11-13 Buy

Caffeic acid Chemical Properties,Uses,Production

Physical and Chemical Properties

Caffeic acid, scientific name: "3-(3,4-dihydroxyphenyl)-2-propenoic acid." Molecular formula: C9H8O4; the molecular weight: 180.16. It is presented in plants such as coffee in the form of chlorogenic acid. It is yellow crystals with melting point being 223~225 °C. When it is precipitated in concentrated solution, it contains no crystal water. However, precipitate of crystals from dilute solution contains one molecule of crystallized water. It is slightly soluble in water, and easily soluble in hot water, cold ethanol, and ethyl acetate. Its alkaline solution is orange and exhibits dark green when being mixed with ferric chloride.
Application: caffeic acid is safe to be applied in cosmetics and has a broader antibacterial and antiviral activity. It can also absorb ultraviolet radiation. A low concentration of it already has inhibitory efficacy on the generation of skin melanin. Its applied amount in the beauty products for whitening is at the range of 0.5 to 2%. It can also be used as additive for the oxidized hair dyes which is good for enhancing the strength of the color.
Preparation: it can be produced from the Perkin’s reaction between protocatechuic aldehyde and acetic acid,As follows:
Reaction formula

Extraction Method

Caffeic acid belongs to common phenolic compounds with effects of increasing the levels of white blood cells. It is easily to be confused with caffeine and is widely distributed in the plant kingdom. Its major plant sources include lemon peel, Ranunculaceae cimicifuga rhizome, and valerian root. Caffeic acid, together with ferulic acid, erucic acid, and p-hydroxy cinnamic acid are ubiquitous hydroxy cinnamic acid-class molecule distributed in various kinds of plants. This kind of products has conjugated double bonds in the side chain of the molecular structure, and thus exhibiting significant fluorescence upon ultraviolet light, mostly showing bluish color fluorescence. This is a advantage for paper chromatography tests or thin layer chromatography tests.
Extraction Method: Single spike cimicifuga rhizome is extracted with methanol which is removed through concentration under reduced pressure. Add hot water to the residue to dissolve it. Heating the water to dissolve the residue, and further filter the insolubles upon heating. After cooling, add benzene for extraction with the benzene solution being washed with 1% aqueous sodium bicarbonate and further collecting the washed solution. Add dilute hydrochloric acid for acidification, and then apply benzene to remove the free organic acid; Concentrate under reduced pressure to get rid of the benzene with the residue being the enriched product of caffeic acid.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Drugs for white blood cells increase

Caffeic acid is a kind of drugs for stopping bleeding as well as increasing the number of white blood cell with effects of contracting microvascular coagulation, improving the function of coagulation factors, and increasing white blood cells and platelets. It is suitable for preventing bleeding or stopping bleeding in surgeries as well as for stopping bleeding for bleeding diseases in internal medicine, and obstetrics and gynecology. It is also suitable for treating leukopenia and thrombocytopenia caused by a variety of reasons.

HPLC determination of caffeic acid in dandelion

[For the test] Compositae dandelion: Taraxacum mongolicum Hand. Mazz, Alkali land dandelion T. sinicum Kitag.
(1) Chromatographic conditions: take octadecylsilane silica gel as a filling agent; methanol-phosphate buffer (sodium dihydrogen phosphate 1.56g, add water to dissolve it in 1000 ml, add 1% of phosphoric acid solution for adjusting to pH 3.8 to 4.0, that’s it) (23:77) as the mobile phase; detection wavelength is 323 nm; column temperature should be 40 °C. Number of theoretical plates should be calculated according to the caffeic acid peak and should not be less than 3,000.
(2) the preparation of the reference solution: take 7.5 mg of caffeic acid reference substance, accurately weigh it and transfer it into the 50ml volumetric flask; add methanol to certain scale, shake; take precise amount of 2ml and put into 10ml volumetric flask, add methanol to the scale , shake, to obtain the reference solution (containing caffeic acid 30μg per ml).
(3) Preparation of sample solution: Take about 1 g of medicine powder, accurately weigh it, and put it in 50ml Erlenmeyer flask, precisely add 10 mL of methanol solution containing 5% formic acid, seal, shake, weigh, and subject to ultrasonic treatment for 30min, remove, cool, then weigh again; use the methanol solution of 5% formic acid to complement the weight loss, shake, centrifuge, and take the supernatant for being filtrated through microporous membrane (0.45μm) with the filtrate being placed in brown bottle to obtain the sample solution.
(4) Determination: separately and precisely pipette 10μl of both reference solution and sample solution and transfer into the liquid chromatography for measurement.
(5) Measurement results: calculated from the dry products of dandelion herbs, the caffeic acid content should not be less than 0.02%.

Chemical Properties

It is yellow crystals and can be dissolved in water and ethanol.


1. Reagents for Organic Synthesis. 2. Intermediate of caffeic acid; can be used in organic synthesis. 3. Used for Biochemical studies.


Toxic Chemicals

Toxicity grading


Acute toxicity

Intraperitoneal administration-rat LDL0: 1500 mg/kg

Flammability and hazard characteristics

Thermal decomposition causes irritating smoke

Storage Characteristics

Treasury: ventilation low-temperature and dry.

Chemical Properties

Light yellow to greenish-yellow powder


antineoplastic, PGE2 synthase inhibitor, PK inhibitor


Caffeic Acid is a constituent of plants, probably occurs in plants only in conjugated forms. Caffeic acid is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal sources of biomass. Caffeic acid is one of the main natural phenols in argan oi.

Extinguishing agent

Water, powder, CO2, foam.

General Description

Yellow prisms or plates (from chloroform or ligroin) or pale yellow granules. Alkaline solutions turn from yellow to orange.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Caffeic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Caffeic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Caffeic acid emits acrid smoke and fumes.

Fire Hazard

Flash point data for Caffeic acid are not available; however, Caffeic acid is probably combustible.

Purification Methods

Recrystallise this antioxidant from water. [Beilstein 10 IV 1776.]

Caffeic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Caffeic acid Suppliers

Global( 337)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691 CHINA 295 58
Dongfan Chem. Co., Ltd.
021-34500607 13391355195
021-33321290 CHINA 61 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22059 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32764 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 893 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1582 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897 CHINA 2200 58
career henan chemical co
+86-371-86658258 CHINA 20001 58

View Lastest Price from Caffeic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-10-04 Caffeic acid
US $1.00 / KG 1KG 99%(Customizable specifications) 800kg Shaanxi Yikanglong Biotechnology Co., Ltd.
2018-08-20 Caffeic acid
US $1.00 / KG 1G 98% 100KG career henan chemical co

Caffeic acid Spectrum

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