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SUC-LEU-LEU-VAL-TYR-AMC

SUC-LEU-LEU-VAL-TYR-AMC structure

CAS No.: 94367-21-2

Chemical Name:: SUC-LEU-LEU-VAL-TYR-AMC

Synonyms: Z-LLVY-AMC;SUC-LLVY-AMC;Felypressin Impurity 8;SUC-LEU-LEU-VAL-TYR-MCA;SUC-LEU-LEU-VAL-TYR-AMC;Suc-Leu-Leu-Val-Tyr-AMC(TFA);CALPAIN SUBSTRATE (FLUOROGENIC);SUC-LEU-LEU-VAL-TYR-AMC USP/EP/BP;PROTEASOME SUBSTRATE III (FLUOROGENIC);CHYMOTRYPSIN SUBSTRATE III, FLUOROGENIC

CBNumber:: CB6290865

Molecular Formula:: C40H53N5O10

Molecular Weight:: 763.88

MDL Number:: MFCD00080248

MOL File:: 94367-21-2.mol

MSDS File:: SDS

Last updated:2024-03-27 11:49:37

Request For Quotation

SUC-LEU-LEU-VAL-TYR-AMC Properties

Boiling point	1116.8±65.0 °C(Predicted)
Density	1.249±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 20 mg/ml), or in DMF (up to 10 mg/ml)
form	Lyophilized solid
pka	4.69±0.10(Predicted)
color	White to Off-White
Sequence	Suc-Leu-Leu-Val-Tyr-AMC
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
FDA UNII	7GVY2DYZ80

SAFETY

Risk and Safety Statements

Hazard statements	H413
Precautionary statements	P273
WGK Germany	3

SUC-LEU-LEU-VAL-TYR-AMC price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S6510	N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin ≥90% (HPLC)	94367-21-2	1mg	$65.7	2024-03-01	Buy
Sigma-Aldrich	S6510	N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin ≥90% (HPLC)	94367-21-2	5mg	$187	2024-03-01	Buy
Alfa Aesar	J66784	Chymotrypsin Substrate III, fluorogenic	94367-21-2	1mg	$58.9	2023-06-20	Buy
Cayman Chemical	10008119	Suc-Leu-Leu-Val-Tyr-AMC ≥98%	94367-21-2	1mg	$34	2024-03-01	Buy
Cayman Chemical	10008119	Suc-Leu-Leu-Val-Tyr-AMC ≥98%	94367-21-2	5mg	$85	2024-03-01	Buy

Product number	Packaging	Price	Buy
S6510	1mg	$65.7	Buy
S6510	5mg	$187	Buy
J66784	1mg	$58.9	Buy
10008119	1mg	$34	Buy
10008119	5mg	$85	Buy

SUC-LEU-LEU-VAL-TYR-AMC Chemical Properties,Uses,Production

Description

Suc-Leu-Leu-Val-Tyr-AMC (94367-21-2) is a fluorogenic substrate for the chymotryptic activity of the 20S proteasome1 and other chymotrypsin-like proteases, as well as calpains2. A commonly used substrate for assaying proteasomal enzymatic activity.3,4 Excitation max.: 360 nm; emission max.: 460 nm.

Uses

Suc-Leu-Leu-Val-Tyr-AMC is a fluorgenic substrate for chymotrypsin-like proteases, as well as calpains. It can be used to treat tuberculosis.

Definition

ChEBI: A tetrapeptide compound with a succinyl group at the N-terminal and a 7-amino-4-methylcoumarin group at the C-terminal.

Biochem/physiol Actions

In the presence of chymotrypsin-like enzyme activity, the fluorophore, 7-amido-4-methylcoumarin is released from N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin. The fluorescence obtained is a measure of the enzyme activity.6

References

1) Stein et al. (1996), Kinetic characterization of the chymotryptic activity of the 20S proteasome; Biochemistry, 35 3899 2) Sasaki et al. (1984), Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates; J. Biol. Chem., 259 12489 3) Hamouda et al. (2014), The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells; Oncotarget, 5 6252 4) Min et al. (2017), USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; J. Neurochem,, 140 826

SUC-LEU-LEU-VAL-TYR-AMC Preparation Products And Raw materials

Raw materials

Preparation Products

SUC-LEU-LEU-VAL-TYR-AMC Suppliers

Global( 118)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2944	58

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58
Chengdu Youngshe Chemical Co., Ltd.	58
LEAP CHEM CO., LTD.	58
China National Standard Pharmaceutical Corporation Limited	58
Nanjing TGpeptide	58
Zhejiang Hangyu API Co., Ltd	58

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Z-LLVY-AMC succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide SUC-LEU-LEU-VAL-TYR-AMC SUC-LEU-LEU-VAL-TYR-MCA SUC-LEU-LEU-VAL-TYR-7-AMINO-4-METHYLCOUMARIN SUCCINYL-L-LEUCYL-L-LEUCYL-L-VALYL-L-TYROSINE-4-METHYLCOUMARINYL-7-AMIDE SUCCINYL-L-LEUCYL-L-LEUCYL-L-VALYL-L-TYROSINE 4-METHYLCOUMARYL-7-AMIDE PROTEASOME 20S, (SUC-LEU-LEU-VAL-TYR-AMC) PROTEASOME SUBSTRATE III (FLUOROGENIC) N-SUCCINYL-LEU-LEU-VAL-TYR 7-AMIDO-4-METHYLCOUMARIN N-SUCCINYL-LEU-LEU-VAL-TYR-7-AMINO-4-METHYLCOUMARIN AMC N-SUCCINYL-L-LEUCYL-L-LEUCYL-L-VALYL-L-TYROSINE-4-METHYLCOUMARYL-7-AMIDE N-SUCCINYL-LEU-LEU-VAL-TYR 7-AMIDO-4-*ME THYLCOUMARI N-Succinyl-l-leucyl-l-leucyl-l-valyl-l-tyrosine-4-methylcoumaryl-7-amidefluorogenicsubstrateforchymotryspin CALPAIN SUBSTRATE (FLUOROGENIC) CHYMOTRYPSIN SUBSTRATE III, FLUOROGENIC 4-[[1-[[1-[[(1S)-1-[[(1S)-1-(4-hydroxybenzyl)-2-keto-2-[(2-keto-4-methyl-chromen-7-yl)amino]ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]amino]-4-keto-butyric acid 4-[[1-[[1-[[(2S)-1-[[(2S)-3-(4-hydroxyphenyl)-1-[(4-methyl-2-oxo-chromen-7-yl)amino]-1-oxo-propan-2-yl]amino]-3-methyl-1-oxo-butan-2-yl]amino]-4-methyl-1-oxo-pentan-2-yl]amino]-4-methyl-1-oxo-pentan-2-yl]amino]-4-oxo-butanoic acid 4-[[1-[[1-[[(2S)-1-[[(2S)-3-(4-hydroxyphenyl)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid CHYMOTRYPSIN SUBSTRATE III, FLUOROGENIC ; SUC-LEU-LEU-VAL-TYR-AMC succinyl-Leu-Leu-Val-Tyr-7-amino-4-methylcoumarin SUC-LLVY-AMC L-Tyrosinamide, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- SUC-LEU-LEU-VAL-TYR-AMC USP/EP/BP Felypressin Impurity 8 Suc-Leu-Leu-Val-Tyr-AMC(TFA) 94367-21-2 C40H53N5O10 BioChemical Biochemicals and Reagents Cell Signaling Enzymes Application Index Apoptosis Products Calpain Enzymes, Inhibitors, and Substrates Fluorimetric Substrates Pepetides