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D-TUBOCURARINE CHLORIDE

D-TUBOCURARINE CHLORIDE
D-TUBOCURARINE CHLORIDE structure
CAS No.
57-94-3
Chemical Name:
D-TUBOCURARINE CHLORIDE
Synonyms
CURARE;tubadil;tubarine;amerizol;Tubocurare;intocostrin;curarin-haf;delacurarine;intocostrinet;TUBOCURARINE CHLORIDE
CBNumber:
CB6296605
Molecular Formula:
C37H42Cl2N2O6
Formula Weight:
681.65
MOL File:
57-94-3.mol

D-TUBOCURARINE CHLORIDE Properties

Melting point:
274~275℃
alpha 
D20-25 +215° (c = 0.25-0.3 g/100 ml)
Density 
1.2074 (rough estimate)
refractive index 
1.7350 (estimate)
storage temp. 
2-8°C
pka
pK: 7.4(at 25℃)
SAFETY
  • Risk and Safety Statements
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS  YO4900000
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 in mice, rats (mg/kg): 33.2, 27.8 orally in DMSO; 59.5, 36.9 orally in water (Rosen)

D-TUBOCURARINE CHLORIDE price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 5.05145 (+)-Tubocurarine Chloride - CAS 57-94-3 - Calbiochem 57-94-3 5051450001 $42.5 2019-12-02 Buy

D-TUBOCURARINE CHLORIDE Chemical Properties,Uses,Production

Chemical Properties

White to light-tan crystalline alkaloid; odorless. Mp 270C with decomposition. Soluble in water and alcohol; insoluble in acetone, chloroform, and ether; aqueous solution is strongly dextrorotatory (specific rotation for 1% solution of anhydrous ?208 to +218 degrees).

Uses

Neuromuscular blocking agent.

Hazard

Highly toxic.

Biological Activity

Competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT 3 and GABA A receptor antagonist.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human toxicity: Large doses and overdoses may cause respiratory paralysis and hypotension. When heated to decomposition it emits very toxic fumes of NOx and Cl-. Used as a muscle relaxant.

Purification Methods

Crystallise this chloride from water. It forms various hydrates. The hydrochloride pentahydrate has m 268-269o (from H2O) and [] D +190o (0.5, H2O). Its solubility in H2O at 25o is 50mg/mL. [Beilstein 27 II 897, 27 III/IV 8727.]

D-TUBOCURARINE CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products


D-TUBOCURARINE CHLORIDE Spectrum


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