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1-(4-Chlorobenzhydryl)piperazine

1-(4-Chlorobenzhydryl)piperazine structure

CAS No.: 303-26-4

Chemical Name:: 1-(4-Chlorobenzhydryl)piperazine

Synonyms: Norchlorcyclizine;Hydroxyzine Related CoMpound A;1-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZINE;NSC 8616;USP CBHP;NSC 86164;AKOS BBS-00003606;Cetirizine USP A;TIMTEC-BB SBB002998;Cetirizine -EP-Imp-A

CBNumber:: CB6297354

Molecular Formula:: C17H19ClN2

Molecular Weight:: 286.8

MDL Number:: MFCD00005965

MOL File:: 303-26-4.mol

MSDS File:: SDS

Last updated:2023-10-08 13:01:37

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1-(4-Chlorobenzhydryl)piperazine Properties

Melting point	65-70 °C (lit.)
Boiling point	178-180 °C/0.5 mmHg (lit.)
Density	1.0912 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5749 (estimate)
Flash point	>230 °F
storage temp.	2-8°C
solubility	soluble in Methanol
form	Crystalline Powder
pka	8.99±0.10(Predicted)
color	White to light beige
Water Solubility	144.6mg/L at 25℃
LogP	3.4 at 25℃
CAS DataBase Reference	303-26-4(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	T875VN0D6E
NIST Chemistry Reference	Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-(303-26-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07,GHS08

Signal word

Danger

Hazard statements

H315-H317-H318-H361fd

Precautionary statements

P201-P202-P280-P302+P352-P305+P351+P338-P308+P313

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39-24/25

WGK Germany

RTECS

TL1772000

Hazard Note

Irritant

HS Code

29339900

NFPA 704

	1
3		0

1-(4-Chlorobenzhydryl)piperazine price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2872	Hydroxyzine Related Compound A pharmaceutical secondary standard, certified reference material	303-26-4	50MG	$461	2024-03-01	Buy
Sigma-Aldrich	C24507	1-(4-Chlorobenzhydryl)piperazine technical grade, 90%	303-26-4	1g	$53.2	2024-03-01	Buy
Sigma-Aldrich	1333058	Hydroxyzine Related Compound A United States Pharmacopeia (USP) Reference Standard	303-26-4	25mg	$1490	2024-03-01	Buy
TCI Chemical	C1611	1-(4-Chlorobenzhydryl)piperazine >98.0%(GC)	303-26-4	1g	$47	2024-03-01	Buy
TCI Chemical	C1611	1-(4-Chlorobenzhydryl)piperazine >98.0%(GC)	303-26-4	5g	$136	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR2872	50MG	$461	Buy
C24507	1g	$53.2	Buy
1333058	25mg	$1490	Buy
C1611	1g	$47	Buy
C1611	5g	$136	Buy

1-(4-Chlorobenzhydryl)piperazine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A metabolite of Cetirizine (C281100) and Hydroxyzine. Citirizine impurity A.

Uses

Cetrizine Dihydrochloride intermediate

Preparation

Preparation of 1-[(4-chlorophenyl)phenylmethyl]piperazine. (CPMP)
About 0.5 mL of DMF, 0.1 g of KI and 10 g (0.12 mol) of piperazine were mixed with 15 mL of toluene and heated to 80oC for 0.5 h. This mixture at 80oC was mixed with 4-CBC in toluene and the temperature was maintained at 80oC for a period of 2 h followed by refluxing at the same temperature for 12h. The reaction mixture was then cooled to 20oC. The toluene layer was washed twice with 20 mL of water and treated with HCl (15 mL conc. HCl in 5mL of water) at 5-10oC. The reaction mixture was filtered and the aqueous layer was separated from the filtrate. About 10 mL of toluene and 10 mL of methylene dichloride (MDC) washes were given to the aqueous layer and neutralized with 22 mL of 30 % NaOH solution at 10oC and maintained at 20oC for 2h. The solid compound formed was filtered, sucked and dried at 50oC for 3 h.Yield: 92 %; m.p: 63-65oC.

Flammability and Explosibility

Not classified

Safety Profile

An experimental teratogen.Experimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and Clí.

1-(4-Chlorobenzhydryl)piperazine synthesis

Synthesis of 1-(4-Chlorobenzhydryl)piperazine from Piperazine and 4-Chlorobenzhydrylchloride

1-(4-Chlorobenzhydryl)piperazine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Potassium iodide Calcium chloride Toluene Potassium carbonate

2-Butanone Piperazine 4-Chlorobenzhydrol Ethyl acetate Dichloromethane

Methanol Magnesium sulfate Thionyl chloride PETROLEUM ETHER 1-Piperazinecarboxylic acid, 4-[(4-chlorophenyl)phenylmethyl]-, 4-nitrophenyl ester

1155402-49-5 4-Hydroxybenzoic acid 4-Chlorobenzophenone

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Preparation Products

1-(4-Chlorobenzhydryl)piperazine Suppliers

Global( 328)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	7836	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Xiamen AmoyChem Co., Ltd	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from 1-(4-Chlorobenzhydryl)piperazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-10	1-(4-Chlorobenzhydryl)piperazine 303-26-4	US $0.00 / kg	1kg	98%	200kg	Shanghai Joiny Pharmaceutical Co.,LTD
2023-10-09	1-(4-Chlorobenzhydryl)piperazine 303-26-4	US $0.00 / kg	1kg	0.99	20tons	Hebei Yanxi Chemical Co., Ltd.
2022-10-11	1-(4-Chlorobenzhydryl)piperazine 303-26-4	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

1-(4-Chlorobenzhydryl)piperazine
303-26-4
US $0.00 / kg
98%
Shanghai Joiny Pharmaceutical Co.,LTD

1-(4-Chlorobenzhydryl)piperazine
303-26-4
US $0.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

1-(4-Chlorobenzhydryl)piperazine
303-26-4
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

1-(4-Chlorobenzhydryl)piperazine Spectrum

1-(4-Chlorobenzhydryl)piperazine(303-26-4)¹HNMR 1-(4-Chlorobenzhydryl)piperazine(303-26-4)Raman 1-(4-Chlorobenzhydryl)piperazine(303-26-4)IR

303-26-4(1-(4-Chlorobenzhydryl)piperazine)Related Search:

2-Diphenylmethylpiperidine hydrochloride 1-Methylpiperazine 2-Methylpiperazine 4-(Chloromethyl)benzoic acid Vinylbenzyl chloride

1-BENZHYDRYLPIPERAZINE tert-Butyldimethylsilyl chloride 1,2-Dimethylhydrazine Dihydrochloride DIMETHYLTHEXYLSILYL CHLORIDE Piperazine

N,N'-Dimethylpiperazine 2,6-Dimethylpiperazine Hydroxyzine dihydrochloride Hydroxydiethylphenamine Acetic acid, 2-[2-[2-[4-[(4- chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]ethoxy]-

Cetirizine EP Impurity E Cetirizine EP Impurity B (RS)-2-[2-[4-[(2-Chloro-phenyl)phenylMethyl]piperazin-1-yl]ethoxy]aceticAcidDihydrochloride

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Levocetrizine EP IMpurity A 1-(1-4-Chlorobenzhdryl) piperazine Meclozine impurity H Cetirizine EP Impurity A 1-(4-Chloro-alpha-phenylbenzyl)piperazine 1-(alpha-Phenyl-4-chlorobenzyl)piperazine 1-(p-chloro-alpha-phenylbenzyl)-piperazin 4-(4-Chlorobenzhydryl)piperazine Piperazine, 1-(alpha-(4-chlorophenyl)benzyl)- Piperazine, 1-(p-chloro-alpha-phenylbenzyl)- N-(4-Chlorophenyl)phenylmethylpiperazine 1-(4-CHLOROBENZHYDRYL)PIPERAZINE, TECH., 4-(Chlorobenzhydryl)Piperazine(Purified)Hydroxyzine/CetirizineEp AKOS BBS-00003606 1-(4-CHLOROBENZHYDRYL)PIPERAZINE 1-(4-CHLORODIPHENYLMETHYL)-PIPERAZINE 1-(4-CHLOROPHENYLMETHYL)PIPERAZINE N-(4-CHLOROBENZYLHYDRYL)PIPERAZINE N-(4-CHLOROBENZHYDRYL)-PIPERAZINE N-(P-CHLOROBENZHYDRYL)-PIPERAZINE TIMTEC-BB SBB002998 1-(4-Chlorobenzhydryl)piperazine, 90-95% 1-(p-Chloro-a-phenylbenzyl)-piperazine NSC 8616 1-(p-chloro-alpha-phenylbenzyl)-piperazine 1-(4-Chlorobenzhydryl)piperazine technical grade, 90% 1-(4-Chlorobenzhydryl)-piperizine 1-((4-chlorophenyl)phenylmethyl)-piperazin 1-(4-CHLOROBENZYLHYDRYL) PIPERAZINE (1-(p-Chloro- -phenylbenzyl)-piperazine Piperazine, 1-[(4-chlorophenyl)phenylmethyl]- NSC 86164 1-(4-Chloro-a-phenylbenzyl)piperazine 4-(α-Piperazinobenzyl)phenyl chloride 1-(4-Chlorobenzhydry)piperazine Piperazine, 1-(alpha-(4-chloropheny Hydroxyzine Related Compound A (25 mg) (p-Chlorobenzhydrylpiperazine) 1-(4-Chlorobenzhydryl)piperazine, 90-95% 5GR 1-(4-chlorobenzhydryl) Buclizine HCl IMpurity (BP/EP) Cetirizine IMpurity-A(EP/BP) Hydroxyzine EP Impurity A Cetirizine -EP-Imp-A Cetirizine Impurity 9（Cetirizine EP Impurity A） Buclizine Impurity 1 Hydroxyzine Related Compound A (1-[(4-Chlorophenyl)phenylmethyl]piperazine) (1333058) Meclozine impurity H (Y0001311) Cetirizine EP impurity AQ: What is Cetirizine EP impurity A Q: What is the CAS Number of Cetirizine EP impurity A Q: What is the storage condition of Cetirizine EP impurity A Cetirizine impurity A (C0980651) N-(4-Chloro Benzhydryl)Piperazine/1-(4-Chlorobenzhydryl)piperazine Cetirizine Impurity99 Levocetirizine EP Impurity A/Hydroxyzine EP Impurity A Hydroxyzine EP Impurity A/ Hydroxyzine Related Compound A (Cetirizine EP Impurity A/ Cetirizine Related Compound A/ Cetirizine CBHP Impurity) Cetirizine EP Impurity A/ Cetirizine Related Compound A (Cetirizine CBHP Impurity/ Hydroxyzine EP Impurity A/ Hydroxyzine Related Compound A) Cetirizine USP A Meclozine EP Impurity H USP CBHP Meclizine EP Impurity H