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Z-LEU-LEU-GLU-AMC

Z-LEU-LEU-GLU-AMC structure

CAS No.: 348086-66-8

Chemical Name:: Z-LEU-LEU-GLU-AMC

Synonyms: Z-ILE-AMC;Z-LLE-AMC;Z-LLG-AMC;Z-LEU-LEU-GLU-MCA;Z-LEU-LEU-GLU-AMC;Z-LEU-LEU-GLY-AMC;CBZ-LEU-LEU-GLU-AMC;Proteasome Substrate II;Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC;PROTEASOME SUBSTRATE II (FLUOROGENIC)

CBNumber:: CB6298942

Molecular Formula:: C35H44N4O9

Molecular Weight:: 664.75

MDL Number:: MFCD01074989

MOL File:: 348086-66-8.mol

Last updated:2023-06-30 15:45:59

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Z-LEU-LEU-GLU-AMC Properties

Boiling point	967.8±65.0 °C(Predicted)
Density	1.253±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble
form	solid
pka	4.43±0.10(Predicted)
color	Solid lyophilized powder

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

Z-LEU-LEU-GLU-AMC price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C0483	Z-Leu-Leu-Glu-7-amido-4-methylcoumarin ≥95%, solid	348086-66-8	5MG	$404	2023-06-20	Buy
Alfa Aesar	J64613	Z-Leu-Leu-Glu-7-amino-4-methylcoumarin	348086-66-8	5mg	$141	2023-06-20	Buy
Cayman Chemical	10008117	Z-LLE-AMC ≥95%	348086-66-8	1mg	$44	2024-03-01	Buy
Cayman Chemical	10008117	Z-LLE-AMC ≥95%	348086-66-8	5mg	$130	2024-03-01	Buy
Cayman Chemical	10008117	Z-LLE-AMC ≥95%	348086-66-8	10mg	$235	2024-03-01	Buy

Product number	Packaging	Price	Buy
C0483	5MG	$404	Buy
J64613	5mg	$141	Buy
10008117	1mg	$44	Buy
10008117	5mg	$130	Buy
10008117	10mg	$235	Buy

Z-LEU-LEU-GLU-AMC Chemical Properties,Uses,Production

Description

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.

Uses

A fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole

Uses

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.

General Description

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.

Biochem/physiol Actions

Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.

storage

+4°C

Z-LEU-LEU-GLU-AMC Preparation Products And Raw materials

Raw materials

Preparation Products

Z-LEU-LEU-GLU-AMC Suppliers

Global( 84)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2944	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696;	info@hanhongsci.com	China	42982	64

Supplier	Advantage
Career Henan Chemica Co	58
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nextpeptide Inc	58
Chengdu Youngshe Chemical Co., Ltd.	58
Nanjing TGpeptide	58
Zhejiang Hangyu API Co., Ltd	58
DONBOO AMINO ACID COMPANY	58
VDM Biochemicals	64
Shanghai Hanhong Scientific Co.,Ltd.	64

348086-66-8(Z-LEU-LEU-GLU-AMC)Related Search:

Z-LEU-LEU-ARG-AMC Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Z-LEU-LEU-OH Z-LLL-AMC BENZYLOXYCARBONYL-L-LEUCYL-L-ARGINYLGLYCYLGLYCINE 4-METHYLCOUMARYL-7-AMIDE

H-GLU(AMC)-OH MG-115 Z-LEU-LEU-GLU-AMC Z-LEU-LEU-GLU-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN GLUTAMIC ACID(ANILIDE)-OH

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CBZ-LEU-LEU-GLU-AMC CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-GLUTAMIC-ACID-ALPHA-(4-METHYLCOUMARINYL)-7-AMIDE BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-GLUTAMIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE) PROTEASOME SUBSTRATE II (FLUOROGENIC) Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN Z-LEU-LEU-GLU-7-AMINO-4-METHYLCOUMARIN Z-LEU-LEU-GLU-AMC Z-LEU-LEU-GLU-MCA Z-LLE-AMC Z-ILE-AMC N-[(Phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alpha-glutamine Z-LLG-AMC Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC (5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid Z-LEU-LEU-GLY-AMC benzyloxycarbonyl-L-leucyl-L-leucyl-L-glutamic acid α-(4-methylcoumaryl-7-amide) Proteasome Substrate II L-α-Glutamine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- 348086-66-8 C35H44N4O9 Proteasome substrate II.