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4-Fluorobenzaldehyde

4-Fluorobenzaldehyde Structure
4-Fluorobenzaldehyde structure
CAS No.
459-57-4
Chemical Name:
4-Fluorobenzaldehyde
Synonyms
PFBA;P-FLUOROBENZALDEHYDE;PFAD;Benzaldehyde, 4-fluoro-;NSC 68095;JACS-459-57-4;AKOS BBS-00003166;4-Fluorbenzaldehyd;P-FLUORBENZALDEHYDE;p-Fluoro benzaldehy
CBNumber:
CB6299747
Molecular Formula:
C7H5FO
Molecular Weight:
124.11
MDL Number:
MFCD00003378
MOL File:
459-57-4.mol
MSDS File:
SDS
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
4-Fluorobenzaldehyde 98% 128376 10g $30.3
4-Fluorobenzaldehyde 98% 128376 50g $79.3
4-Fluorobenzaldehyde for synthesis 8.18537 25mL $51.5
4-Fluorobenzaldehyde >98.0%(GC) F0191 25mL $32
4-Fluorobenzaldehyde >98.0%(GC) F0191 250mL $183
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4-Fluorobenzaldehyde Properties

Melting point -10 °C (lit.)
Boiling point 181 °C/758 mmHg (lit.)
Density 1.157 g/mL at 25 °C (lit.)
vapor pressure 19 hPa (70 °C)
refractive index n20/D 1.521(lit.)
Flash point 134 °F
storage temp. Store below +30°C.
solubility Chloroform, Methanol
form Liquid
Specific Gravity 1.157
color Clear colorless to yellow
Water Solubility IMMISCIBLE
Sensitive Air Sensitive
BRN 385857
Stability Air Sensitive
InChIKey UOQXIWFBQSVDPP-UHFFFAOYSA-N
CAS DataBase Reference 459-57-4(CAS DataBase Reference)
FDA UNII N8681893GA
NIST Chemistry Reference Benzaldehyde, 4-fluoro-(459-57-4)
EPA Substance Registry System Benzaldehyde, 4-fluoro- (459-57-4)
UNSPSC Code 12352114
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P210-P233-P240-P241-P303+P361+P353-P305+P351+P338
Hazard Codes  Xi,F
Risk Statements  36/37/38
Safety Statements  26-36-37/39-36/37/39-27
RIDADR  UN 1989 3/PG 3
WGK Germany  2
F  9-23
Hazard Note  Flammable
TSCA  T
HazardClass  3.2
PackingGroup  III
HS Code  29130000
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

4-Fluorobenzaldehyde price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 128376 4-Fluorobenzaldehyde 98% 459-57-4 10g $30.3 2025-07-31 Buy
Sigma-Aldrich 128376 4-Fluorobenzaldehyde 98% 459-57-4 50g $79.3 2025-07-31 Buy
Sigma-Aldrich 8.18537 4-Fluorobenzaldehyde for synthesis 459-57-4 25mL $51.5 2023-01-07 Buy
TCI Chemical F0191 4-Fluorobenzaldehyde >98.0%(GC) 459-57-4 25mL $32 2025-07-31 Buy
TCI Chemical F0191 4-Fluorobenzaldehyde >98.0%(GC) 459-57-4 250mL $183 2025-07-31 Buy
Product number Packaging Price Buy
128376 10g $30.3 Buy
128376 50g $79.3 Buy
8.18537 25mL $51.5 Buy
F0191 25mL $32 Buy
F0191 250mL $183 Buy

4-Fluorobenzaldehyde Chemical Properties,Uses,Production

Chemical Properties

Clear colorless to yellow liquid

Uses

Usually used in the preparation of pyrazolopyridine UR-13756.

Uses

4-Fluorobenzaldehyde is a fluorinated benzaldehyde with inhibitory activity of mushroom tyrosinase. 4-Fluorobenzaldehyde is commonly used as a synthetic intermediate in the preparation of pharmaceutic al compounds.

Uses

4-Fluorobenzaldehyde is used in the preparation of pyrazolopyridine derivative, which finds application as mitogen-activated protein kinase (MAPK) inhibitor. It also serves as a synthetic intermediate in the preparation of pharmaceutical compounds.

Synthesis

4-Fluorobenzaldehyde is produced by a commercially feasible process. The process comprises heating a mixture of fluorobenzene and a strong Lewis acid with dissolved hydrogen halide in an atmosphere of carbon monoxide at about 45 to about 100° C. and at a total pressure of about 150 psig up to the maximum pressure rating of the reactor. Formed is a reaction mass containing a Lewis acid complex of 4-fluorobenzaldehyde and at least a halobis(fluorophenyl)methane by-product. The complex is broken by quenching the reaction mass with a Lewis acid-solvating liquid to liberate 4-fluorobenzaldehyde. By-product halobis(fluorophenyl)methane is converted to di(fluorophenyl)methanol to avoid potential corrosion problems and formation of light-sensitive color bodies in the recovered 4-fluorobenzaldehyde.

4-Fluorobenzaldehyde synthesis

64002-52-4
459-57-4
Synthesis of 4-Fluorobenzaldehyde from Methanediol, 1-(4-fluorophenyl)-, 1,1-diacetate

4-Fluorobenzaldehyde Preparation Products And Raw materials

Raw materials

4-Chlorobenzaldehyde p-Fluorotoluene Benzyl dichloride 4-Chlorotoluene

Preparation Products

4-N-PROPOXYBENZALDEHYDE 4-Pyrazol-1-yl-benzaldehyde 3-Bromo-4-fluorobenzaldehyde 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide 4-Fluorobenzoic acid
(5-Fluoro-2-methyl-1H-inden-3-yl)acetic acid Rosiglitazone 4-Fluorocinnamic acid DL-3-(4-Fluorophenyl)alanine 4-(1H-Imidazol-1-yl)benzaldehyde
4-Fluoro-3-phenoxybenzaldehyde 6-Fluoro-1-indanone P-TOLUENESULFINIC ACID 4-Fluorostyrene Paroxetine Related Impurity 9
Bis(4-fluorophenyl)-methanone Benzeneacetonitrile, 4-fluoro-α-hydroxy- BMN 673

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4-Fluorobenzaldehyde Suppliers

Global( 719)Suppliers
Supplier Tel Email Country ProdList Advantage
Weifang Dayoo Biochemical Co., Ltd.,
+undefined13305362020 sales@dayoochemical.com China 20 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8767 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 20284 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5249 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13595 58
Shanghai Bojing Chemical Co.,Ltd. 		+86-86-02137122233 +8613795318958 bj1@bj-chem.com China 299 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21610 55
Supplier Advantage
Weifang Dayoo Biochemical Co., Ltd.,
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Dideu Industries Group Limited 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Anhui Ruihan Technology Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Shanghai Bojing Chemical Co.,Ltd. 		55
Henan Tianfu Chemical Co.,Ltd. 		55

View Lastest Price from 4-Fluorobenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Fluorobenzaldehyde pictures 2025-12-15 4-Fluorobenzaldehyde
459-57-4
 0.99 RongNa Biotechnology Co.,Ltd
4-Fluorobenzaldehyde pictures 2025-12-11 4-Fluorobenzaldehyde
459-57-4
 US $1.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
4-Fluorobenzaldehyde pictures 2025-11-18 4-Fluorobenzaldehyde
459-57-4
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

4-Fluorobenzaldehyde Spectrum

4-Fluorobenzaldehyde(459-57-4)MS4-Fluorobenzaldehyde(459-57-4)1HNMR4-Fluorobenzaldehyde(459-57-4)13CNMR4-Fluorobenzaldehyde(459-57-4)IR14-Fluorobenzaldehyde(459-57-4)Raman

459-57-4(4-Fluorobenzaldehyde)Related Search:

4-Fluorobenzoic acid Florfenicol 3-Fluorobenzaldehyde Pentafluorobenzaldehyde 4-Bromofluorobenzene
2,6-Difluorobenzaldehyde Ethyl 4-fluorobenzoate Transfluthrin 1,2-Difluorobenzene 4-Fluoroanisole
4-Fluorobenzoyl chloride 4-Fluorothiophenol 4-Fluoronitrobenzene 4-Fluorobenzyl alcohol 4-Methylbenzyl chloride
4-Chlorobenzaldehyde p-Fluorotoluene 4-Fluoromandelic acid

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4-fluoro-benzaldehyd Benzaldehyde, p-fluoro- PARA FLUOROBENZALDEHYDE FLUOROBENZALDEHYDE(4-) LABOTEST-BB LT00930357 AKOS BBS-00003166 p-Fluorobenzaldehyde 4-Fluorobenzaldehyde 4-Fluorobenzaldehyde,98% 4-Fluorobenzaldehyde99% 4-Fluorbenzaldehyd 4-FLUORO-BENZALDEHYDE 99.5% 19) PARA FLUORO BENZALDEHYDE P-FLUORBENZALDEHYDE 4-FLUOROBENZALDEHYDE 4-Fluorobenzaldehyde≥ 99% (GC) p-Fluoro benzaldehyd 4-Fluorobenzaldehyde, AcroSeal, 98+% 4-Fluorobenzaldehyde for synthesis 4-Fluorobenzaldehyde, 98+%, AcroSeal 4-Fluorobenzaldehyde, 98+% 250ML 4-Fluorobenzaldehyde, 98+% 50ML p-Fluorobenzenecarboxaldehyde NSC 68095 Benzaldehyde, p-fluoro- (6CI,7CI,8CI) p-Fluoro benzaldehy The fluoro benzaldehyde Retigabine Genotoxic Impurity 3: 4-Fluorobenzaldehyde JACS-459-57-4 4-Fluorobenzaldehyde, p-Fluorobenzaldehyde, Benzaldehyde 4-fluoro-, 4-fluoro-benzaldehyde Paroxetine Impurity 58 4-Fluorobenzaldehyde> Atorvastatin Impurity 195 p-Fluorobenzenecarboxaldehyde (Atorvastatin calcium) 4-Fluorobenzaldehyde pure, 98% 4-Fluorobenzaldehyde, 98+%, AcroSeal&trade PFAD PFBA P-FLUOROBENZALDEHYDE Benzaldehyde, 4-fluoro- Atorvastatin Impurity 112 4-Fluorobenzaldehyde CAS.459-57-4 4-Fluoro-4-methylacetophenone 4-Fluorobenzaldehyde， ≥ 97.0% Atorvastatin calcium impurity 69 459-57-4 459-57-0 2615-30-4 Organic Building Blocks C7 Carbonyl Compounds Aldehydes Building Blocks Aldehydes C7 Carbonyl Compounds Fluoro-Aromatics Benzaldehyde Fluorobenzene