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L-Penicillamine

L-Penicillamine
L-Penicillamine structure
CAS No.
1113-41-3
Chemical Name:
L-Penicillamine
Synonyms
l-valin;H-PEN-OH;L-Pen-OH;NSC 241261;3-Mercapto-;L-(+)-βPENICILLAMINE;3-THIOL-VALINE;L-PENICILLAMINE;H-CYS(3-ME 2)-OH
CBNumber:
CB6302922
Molecular Formula:
C5H11NO2S
Formula Weight:
149.21
MOL File:
1113-41-3.mol

L-Penicillamine Properties

Melting point:
206 °C (dec.)(lit.)
alpha 
61.9 º (C=0.5 IN 1 M NAOH)
Density 
1.113 (estimate)
refractive index 
63 ° (C=1, 1mol/L NaOH)
storage temp. 
Store at RT.
form 
Crystalline Powder
color 
White to almost white
optical activity
[α]24/D +61.9°, c = 0.5 in 1 M NaOH
Merck 
14,7088
BRN 
1722374
CAS DataBase Reference
1113-41-3(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280h-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-40-20/21/22
Safety Statements  26-36-22-24/25
WGK Germany  2
RTECS  YV9445500
HS Code  29309090
Toxicity LD50 i.p. in rats: 350 mg/kg (Jaffe)

L-Penicillamine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 196312 L-Penicillamine 99% 1113-41-3 1g $48.7 2018-11-13 Buy
Sigma-Aldrich 196312 L-Penicillamine 99% 1113-41-3 5g $139 2018-11-13 Buy
TCI Chemical P1370 L-Penicillamine >98.0%(T) 1113-41-3 1g $38 2018-11-22 Buy
TCI Chemical P1370 L-Penicillamine >98.0%(T) 1113-41-3 5g $128 2018-11-22 Buy
Alfa Aesar L13923 L-(+)-Penicillamine, 98+% 1113-41-3 250mg $17.8 2018-11-13 Buy

L-Penicillamine Chemical Properties,Uses,Production

Chemical Properties

white to almost white crystalline powder

Uses

As a Penicillin metabolite, L-Penicillamine can be used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.

Definition

ChEBI: The L-enantiomer of penicillamine.

Indications

Penicillamine (Cuprimine) can be used to treat acute, severe rheumatoid arthritis, producing reductions in joint pain, edema, and stiffness.The response to penicillamine is usually delayed (4–12 weeks), and remissions can last several months after withdrawal of treatment. Radiographic evidence of this drug’s efficacy is limited; thus, penicillamine is seldom used to treat rheumatoid arthritis.

Mechanism of action

The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson’s disease (hepatolenticular degeneration) and has also been used in mercury and lead intoxication.

Pharmacology

Penicillamine is readily absorbed from the GI tract and is rapidly excreted in the urine, largely as the intact molecule. Gradually increasing its dose minimizes side effects, which necessitate discontinuance of penicillamine therapy in perhaps one-third of patients. The most common side effects are maculopapular pruritic dermatitis, GI upset, loss of taste sensation, mild to occasionally severe thrombocytopenia and leukopenia,and mild proteinuria, which at times may progress to the nephritic syndrome. Discontinuance of therapy usually results in a rapid disappearance of side effects.

Purification Methods

Same as preceding entry for its enantiomer. [Beilstein 4 IV 3228.]

L-Penicillamine Preparation Products And Raw materials

Raw materials

Preparation Products


L-Penicillamine Suppliers

Global( 103)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Shandong chuangyingchemical Co., Ltd.
13156170209
sale@chuangyingchem.com CHINA 4419 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd +86-13650506873
sales@chemdad.com CHINA 30864 58
Madision Biomedical Co., Ltd. 15114076748 028-86293553
553691721@qq.com China 26 58
ChemPep, Inc. +1 (888) 615-9178 / (561) 791-8787
+1 (561) 791-8728 service@chempep.com United States 2138 57
MINKESH (SHANGHAI) CO., LTD. +86 021 20983811 13167252998
+86 021 23027795 sales@minkesh.com China 56 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from L-Penicillamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-14 L-Penicillamine
1113-41-3
US $1.00 / KG 1KG 98% 1ton career henan chemical co

L-Penicillamine Spectrum


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