daprodustat,GSK1278863
- CAS No.
- 960539-70-2
- Chemical Name:
- daprodustat,GSK1278863
- Synonyms
- CS-1541;GSK1278863;Daprodustat;GSK 1278863 NEW;GSK1278863, >98%;Daprodustat, >98%;GSK1278863,daprodustat;daprodustat,GSK1278863;Daprodustat Impurity 3;GSK1278863; GSK 1278863; GSK-1278863; DAPRODUSTAT
- CBNumber:
- CB63038532
- Molecular Formula:
- C19H27N3O6
- Molecular Weight:
- 393.43
- MDL Number:
- MFCD29924726
- MOL File:
- 960539-70-2.mol
| Melting point | 237-241oC |
|---|---|
| Density | 1.359±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| pka | 3.44±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | JVR38ZM64B |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362-P301+P310+P330-P405 |
daprodustat,GSK1278863 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19915 | Daprodustat ≥98% | 960539-70-2 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19915 | Daprodustat ≥98% | 960539-70-2 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 19915 | Daprodustat ≥98% | 960539-70-2 | 10mg | $261 | 2024-03-01 | Buy |
| Cayman Chemical | 19915 | Daprodustat ≥98% | 960539-70-2 | 25mg | $533 | 2024-03-01 | Buy |
| TRC | D193368 | Daprodustat | 960539-70-2 | 10mg | $90 | 2021-12-16 | Buy |
daprodustat,GSK1278863 Chemical Properties,Uses,Production
Uses
Daprodustat is a novel HIF (Hypoxia inducible factor)-prolyl hydroxylase inhibitor.
Biological Activity
daprodustat (gsk1278863) is a hif-prolyl hydroxylase inhibitor.hypoxia stimulates erythropoietin (epo) release through accumulation of hypoxia-inducible factor 1α (hif-1α), resulting in an increase of erythrocyte production by the bone marrow. hif-prolyl hydroxylase inhibitors have been used to selectively activate the phd-signaling pathway, leading to the stabilization of hifα subunits, which can affect the transcription of hif-responsive genes.
in vitro
in-vitro biotransformation data indicated that gsk1278863 was primarily metabolized by cyp2c8 [1].
References
[1] hara k,takahashi n,wakamatsu a,caltabiano s. pharmacokinetics, pharmacodynamics and safety of single, oral doses of gsk1278863, a novel hif-prolyl hydroxylase inhibitor, in healthy japanese and caucasian subjects. drug metab pharmacokinet.2015 dec;30(6):410-8.
[2] brigandi ra,johnson b,oei c,et al. a novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (gsk1278863) for anemia in ckd: a 28-day, phase 2a randomized trial. am j kidney dis.2016 jun;67(6):861-71.
daprodustat,GSK1278863 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | mack@tongyon.com | China | 2996 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 +8618858568638 | wuzhouding@huihecrop.com | China | 886 | 58 |
Related articles
- Synthesis of Daprodustat
- Daprodustat is synthesised using malonic acid as a raw material by Biginelli reaction, saponification and other reactions.
- Dec 21，2023
View Lastest Price from daprodustat,GSK1278863 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-10-08 | Daprodustat
960539-70-2
|
US $0.00-0.00 / g | 1g | 98% | 100kgs | Wuhan Nutra Biotechnology Co.,Ltd | |
 |
2019-09-06 | daprodustat,GSK1278863
960539-70-2
|
US $1.00 / ASSAYS | 1ASSAYS | 95%~99% | per week:100kg | Career Henan Chemical Co |
-
- Daprodustat
960539-70-2
- US $0.00-0.00 / g
- 98%
- Wuhan Nutra Biotechnology Co.,Ltd
-
- daprodustat,GSK1278863
960539-70-2
- US $1.00 / ASSAYS
- 95%~99%
- Career Henan Chemical Co