CALCEIN-AM
- CAS No.
- 148504-34-1
- Chemical Name:
- CALCEIN-AM
- Synonyms
- CAL-AM;NSC 689290;CALCEIN-AM;AM /Calcein-AM;CALCEIN, AM;CAL-AM;Calcein AM solution;Cellstain- Calcein-AM;Calcein AcetoxyMethyl Ester;-Cellstain-Calcein-AmSolution;Calcein, AM *CAS 148504-34-1*
- CBNumber:
- CB6304173
- Molecular Formula:
- C46H46N2O23
- Molecular Weight:
- 994.86
- MDL Number:
- MFCD28355895
- MOL File:
- 148504-34-1.mol
- MSDS File:
- SDS
| Melting point | >250℃ |
|---|---|
| Boiling point | 982.7±65.0 °C(Predicted) |
| Density | 1.49±0.1 g/cm3(Predicted) |
| refractive index |
n |
| Flash point | 85 °C |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL, clear, colorless to slightly yellow |
| pka | 2.66±0.50(Predicted) |
| form | powder |
| color | Colorless |
| λmax | < 300 nm |
| Biological Applications | Calcium indicators; zinc indicators; cytotoxicity assays; apoptosis assays; viability assays; labile iron pool assays; chemotaxis probes; cell adhesion probes; mitochondrial probes; P-glycoprotein probes;multi-drug resistance probes;treating atherosclerosis,cancer;ischemic disease |
CALCEIN-AM price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C1359 | Calcein AM solution 4?mM in DMSO, ≥90% (HPLC), solution | 148504-34-1 | 100μL | $327 | 2024-03-01 | Buy |
| Sigma-Aldrich | 56496 | Calcein-AM Small Package (20 X 50 μg ), ≥96.0% (HPLC) | 148504-34-1 | 20x50μg | $905 | 2024-03-01 | Buy |
| Sigma-Aldrich | 17783 | Calcein-AM BioReagent, suitable for fluorescence, ≥96.0% (HPLC) | 148504-34-1 | 1mg | $568 | 2024-03-01 | Buy |
| Sigma-Aldrich | 17783 | Calcein-AM BioReagent, suitable for fluorescence, ≥96.0% (HPLC) | 148504-34-1 | 5mg | $2460 | 2024-03-01 | Buy |
| Cayman Chemical | 14948 | Calcein AM ≥90% | 148504-34-1 | 500μg | $73 | 2024-03-01 | Buy |
CALCEIN-AM Chemical Properties,Uses,Production
Uses
A non-fluorescent, membrane permeable probe that can be hydrolyzed to a fluorescent molecule
Uses
Calcein-AM is a hydrophobic non-fluorescent probe that can permeate the plasma membrane and can be hydrolyzed to Calcein (sc-202090), which is an extremely fluorescent and negatively charged molecule. Calcein-AM can be used to stain living cells and in cytoplasmic Schwann cells has been observed to fluoresce bright green. Calcein-AM has been reported to be a neutral substrate for P-glycoprotein (Pgp) and multidrug resistance protein (MRP) and has been used in flow cytometry studies to analyze the function of P-gp and MRP.
Uses
Calcein-AM appears to best satisfy the criteria for assaying cell adhesion and to have the least effect on cell viability and cell functions.
Definition
ChEBI: Calcein am is an organic heteropentacyclic compound that is calcein in which all four carboxy group hydrogens have been substituted by (acetyloxy)methoxy groups and the hyrodgens of the two hydroxy groups have been substituted by acetyl groups. It is a a non-fluorescent probe cleaved to a fluorescent probe by non-specific intracellular esterases. It has a role as a fluorochrome. It is an acetate ester, an organic heteropentacyclic compound, a gamma-lactone, an oxaspiro compound, a member of 2-benzofurans and a xanthene dye. It is functionally related to a calcein.
General Description
Liposomes contain a self-quenching fluorescent dye called calcein. It is a fluorescent dye with excitation and emission wavelengths of 495/515 nm, respectively. It self-quenches at concentrations above 70mM and is commonly used as an indicator of lipid vesicle leakage. The leakage rate is calculated on the basis of the fluorescence increment as the entrapped calcein is leaked out of the liposomal compartment. It is used as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium.
Biochem/physiol Actions
Fluorescent cell permeable derivative of calcein.
storage
-20°C
CALCEIN-AM Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19185 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18457 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
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