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DIPHENOXYLATE HYDROCHLORIDE

DIPHENOXYLATE HYDROCHLORIDE
DIPHENOXYLATE HYDROCHLORIDE structure
CAS No.
3810-80-8
Chemical Name:
DIPHENOXYLATE HYDROCHLORIDE
Synonyms
r1132;DIPHENOXYLATE HCL;DIPHENOXYLATE HYDROCHLORIDE;Diphenoxylate for system suitability;Diphenoxylate hydrochloride solution;Diphenoxylate Hydrochloride CII (200 mg);Diphenoxylate HCL (Subj To Narcotic Permit);DIPHENOXYLATE HYDROCHLORIDE METHANOL SOL UTION;DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC, ANTI;Diphenoxylate Hydrochloride (1.0 mg/ml in Methanol)
CBNumber:
CB6305387
Molecular Formula:
C30H33ClN2O2
Formula Weight:
489.05
MOL File:
3810-80-8.mol

DIPHENOXYLATE HYDROCHLORIDE Properties

Melting point:
220.5-222°
storage temp. 
-20°C
solubility 
Very slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
FDA UNII
W24OD7YW48
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H310+H330-H317-H334
Precautionary statements  P260-P280-P284-P302+P352+P310-P304+P340+P310
RIDADR  1544
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933330000

DIPHENOXYLATE HYDROCHLORIDE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D-143 Diphenoxylate hydrochloride solution 3810-80-8 143-1ml $96.9 2020-08-18 Buy
Sigma-Aldrich 1219008 Diphenoxylate for system suitability 3810-80-8 200mg $485 2020-08-18 Buy

DIPHENOXYLATE HYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.

Originator

Lomotil,Searle,US,1960

Uses

Antiperistaltic; antidiarrheal. Controlled substance (opiate).

Definition

ChEBI: The hydrochloride salt of diphenoxylate.

Manufacturing Process

A mixture of 23 parts of the ethyl ester of 4-phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-
omobutyronitrile in 19 parts of xylene is heated for 24 hours at 100-120°C and then cooled and filtered to remove the precipitate of the hydro
omide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2-diphenyl-4-(4'-carboxy-4'-phenyl-1'- piperidino)butyronitrile thus obtained melts at about 220.5-222°C. See meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester.

Therapeutic Function

Antidiarrheal

Veterinary Drugs and Treatments

Diphenoxylate is an opiate in combination with atropine in antidiarrheal products used primarily in dogs; it also has antitussive properties. Use in cats is controversial and many clinicians do not recommend its use in this species.

DIPHENOXYLATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products


DIPHENOXYLATE HYDROCHLORIDE Suppliers

Global( 23)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29642 58
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15425 60
Alfa Chemistry 1-201-478-8534
1-516-927-0118 inquiry@alfa-chemistry.com United States 9935 60

View Lastest Price from DIPHENOXYLATE HYDROCHLORIDE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-12-20 :DIPHENOXYLATE HYDROCHLORIDE
3810-80-8
US $1.00 / KG 1KG 97%-99.9% 100kg Career Henan Chemical Co

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