ChemicalBook >> CAS DataBase List >>Propargyl-PEG5-amine

Propargyl-PEG5-amine

CAS No.
1589522-46-2
Chemical Name:
Propargyl-PEG5-amine
Synonyms
Alkyne-PEG5-NH2;HC≡C-CH2-PEG6-NH2;PROPARGYL-PEG5-NH2;Propargyl-PEG5-amine;3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine;Propargyl-PEG5-NH2/3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine
CBNumber:
CB63062630
Molecular Formula:
C13H25NO5
Molecular Weight:
275.34
MDL Number:
MFCD27977505
MOL File:
1589522-46-2.mol
Last updated:2024-03-26 17:16:27

Propargyl-PEG5-amine Properties

Boiling point 360.4±37.0 °C(Predicted)
Density 1.049±0.06 g/cm3(Predicted)
solubility DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)
pka 8.74±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Propargyl-PEG5-amine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
BroadPharm BP-22103 Propargyl-PEG5-amine 98% 1589522-46-2 500mg $680 2021-12-16 Buy
Apolloscientific BIPG1726 Propargyl-PEG5-amine 1589522-46-2 250mg $759 2021-12-16 Buy
BroadPharm BP-22103 Propargyl-PEG5-amine 98% 1589522-46-2 1g $1020 2021-12-16 Buy
Acrotein B-1144 Propargyl-PEG5-NH2 97% 1589522-46-2 0.25g $201.66 2021-12-16 Buy
Acrotein B-1144 Propargyl-PEG5-NH2 97% 1589522-46-2 0.5g $302.5 2021-12-16 Buy
Product number Packaging Price Buy
BP-22103 500mg $680 Buy
BIPG1726 250mg $759 Buy
BP-22103 1g $1020 Buy
B-1144 0.25g $201.66 Buy
B-1144 0.5g $302.5 Buy

Propargyl-PEG5-amine Chemical Properties,Uses,Production

Description

Propargyl-PEG5-amine is a propargyl linker that is commonly used as a Click Chemistry reagent for copper-catalyzed reactions with azides. The amine moiety reacts with carboxylic acids, activated NHS esters and other carbonyl compounds. The PEG spacer helps improve the water solubility of the molecule in aqueous media.

Biological Activity

Propargyl-PEG5-amine is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

Non-cleavable

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PEGs

Propargyl-PEG5-amine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 54)Suppliers
Supplier Tel Email Country ProdList Advantage
airuikechemical co., ltd.
+undefined86-15315557071 15315557071@163.com China 527 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196 sale04@alfachem.cn China 12333 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Wuhan Borenpharm Co., Ltd
027-65563561 18717150066 3207347307@qq.com CHINA 1238 58
Hangzhou Huarong Pharm Co., Ltd.
571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3149 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3136 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8475 58
Jilin Chinese Academy of Sciences-yanshen Technology
+undefined18143011203 info@chemextension.com China 22795 58
Xian confluore Biological Technology Co., Ltd.
+86-15680926068 +86-15680926068 1924344760@confluore.cn China 2891 58

View Lastest Price from Propargyl-PEG5-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Propargyl-PEG5-amine pictures 2024-03-26 Propargyl-PEG5-amine
1589522-46-2
US $0.00 / g 5g >98.00% 5g Xian confluore Biological Technology Co., Ltd.
Propargyl-PEG5-amine pictures 2024-03-21 Propargyl-PEG5-amine
1589522-46-2
US $0.00-0.00 / Kg 1Kg 99.9% 200tons airuikechemical co., ltd.
Propargyl-PEG5-amine HC≡C-CH2-PEG6-NH2 Alkyne-PEG5-NH2 PROPARGYL-PEG5-NH2 3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine Propargyl-PEG5-NH2/3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine 1589522-46-2 PROTAC Linker PROTAC peg