N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide
- CAS No.
- 66644-81-3
- Chemical Name:
- N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide
- Synonyms
- VERALIPRIDE;LIR166;Velaripride;N-[(1-Allyl-2-pyrrolidinyl)methyl]-5-sulphamoyl-2-veratramide;LIR 166,inhibit,Dopamine Receptor,Veralipride,Inhibitor,LIR-166;N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide;N-[(1-Allylpyrrolidin-2-yl)methyl]-2,3-dimethoxy-5-sulfamoylbenzamide;2,3-diMethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]Methyl}-5-sulfaMoylbenzaMide;Benzamide, 5-(aminosulfonyl)-2,3-dimethoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-
- CBNumber:
- CB6306612
- Molecular Formula:
- C17H25N3O5S
- Molecular Weight:
- 383.46
- MDL Number:
- MFCD00867658
- MOL File:
- 66644-81-3.mol
- MSDS File:
- SDS
| Melting point | 128 °C |
|---|---|
| Density | 1.230±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 10.02±0.60(Predicted) |
| color | White to Off-White |
| FDA UNII | S7064109UD |
| ATC code | N05AL06 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H312-H302-H332 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501 |
| HS Code | 2935.90.6000 |
N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | V0163 | Veralipride | 66644-81-3 | 10MG | $136 | 2024-03-01 | Buy |
| TRC | V122500 | Veralipride | 66644-81-3 | 2.5mg | $150 | 2021-12-16 | Buy |
| Chem-Impex | 38361 | Veralipride,≥98%(HPLC) ≥98%(HPLC) | 66644-81-3 | 10MG | $153.75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BV162329 | Veralipride | 66644-81-3 | 10mg | $155 | 2021-12-16 | Buy |
| ChemScene | CS-6854 | Veralipride 99.57% | 66644-81-3 | 5mg | $228 | 2021-12-16 | Buy |
N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide Chemical Properties,Uses,Production
Originator
Agreal,Delagrange,France,1980
Uses
Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gaining interest as a non-hormonal treatment for climacteric flushing.
Uses
Labelled Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gain ing interest as a non-hormonal treatment for climacteric flushing.
Definition
ChEBI: Veralipride is a sulfonamide.
Manufacturing Process
7.8 g (0.03 mol) of 2,3-dimethoxy-5-sulfamoylbenzoic acid, 200 ml of
tetrahydrofuran and 7.3 g (0.045 mol) of carbonyldimidazole are placed in a
500 ml flask fitted with an agitator, a thermometer and a condenser.
The mixture is agitated for 30 minutes at normal temperature, then 6.7 g
(0.948 mol) of 1-allyl-2-aminomethylpyrrolidine is added. The mixture is left
under agitation for 5 hours at 20°C, then the solvent is evaporated under
vacuum and the residue treated with 150 ml of water. The crystals are washed
and dried.
6.9 g of N-(1'-allyl-2'-pyrrolidyl-methyl)-2,3-dimethoxy-5-sulfamoyl-
benzamide is obtained. Yield is 60%; melting point 113°C to 114°C.
Therapeutic Function
Menopause treatment
N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| LUYUNJIA CHEMISTRY XIAMEN LIMITED | +86-592-5360779 +86-13055435203 | China | 5996 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |