VU0483605
- CAS No.
- 1623101-11-0
- Chemical Name:
- VU0483605
- Synonyms
- VU0483605;3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide;3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide;2-Chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)phenyl]nicotinamide;3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide;3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]pyridine-2-carboxamide;2-Pyridinecarboxamide, 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-;Inhibitor,inhibit,VU0483605,Metabotropic glutamate receptors,allosteric modulator,brain penetrant,metabotropic glutamate,VU 0483605,mGluR,VU-0483605
- CBNumber:
- CB63067594
- Molecular Formula:
- C20H10Cl3N3O3
- Molecular Weight:
- 446.67
- MDL Number:
- MFCD29770792
- MOL File:
- 1623101-11-0.mol
VU0483605 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16941 | VU0483605 ≥98% | 1623101-11-0 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 16941 | VU0483605 ≥98% | 1623101-11-0 | 5mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 16941 | VU0483605 ≥98% | 1623101-11-0 | 10mg | $143 | 2024-03-01 | Buy |
| TRC | V787575 | VU0483605 | 1623101-11-0 | 50mg | $550 | 2021-12-16 | Buy |
| AK Scientific | SYN5042 | VU0483605 | 1623101-11-0 | 50mg | $585 | 2021-12-16 | Buy |
VU0483605 Chemical Properties,Uses,Production
Uses
VU 0483605 is a positive allosteric modulator of metabotropic glutamate receptors (mGluRs) that preferentially binds mGlu1 over mGlu4 (1,2). VU 0483605 is a mGlu1 antagonist and has potential therapeutic properties for treating schizophrenia.
Biological Activity
vu0483605 is a selective positive allosteric modulator (pam) of mglur1 [1].the metabotropic glutamate receptors (mglurs), members of g-protein-coupled receptors, have been involved in a variety of functions in the central and peripheral nervous systems, such as learning, memory, anxiety, and the perception of pain. the mglurs exist in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, the cerebral cortex, as well as other parts of the brain and in peripheral tissues. mice deficient in mglur1 showed severe motor coordination and spatial learning deficient [2].vu0483605 is a selective positive allosteric modulator (pam) of mglur1. vu0483605 displayed ec50 values of 0.39 and 0.36 μm at human and rat mglur1 receptors, respectively. vu0483605 showed no activity against mglu4 pam with the ec50 of >10 μm. vu0483605 potentiated the response to glutamate in cells stably expressing mglu1 and partially restored the reduction in glutamate-mediated calcium signaling in a mutant cell model of schizophrenia [1].
References
[1] cho h p, garcia-barrantes p m, brogan j t, et al. chemical modulation of mutant mglu1 receptors derived from deleterious grm1 mutations found in schizophrenics[j]. acs chemical biology, 2014, 9(10): 2334-2346.
[2] conquet f, bashir z i, davies c h, et al. motor deficit and impairment of synaptic plasticity in mice lacking mglur1[j]. nature, 1994, 372(6503): 237.
VU0483605 Preparation Products And Raw materials
Raw materials
Preparation Products
VU0483605 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| ELSA BIOTECHNOLOGY CO.,LTD. | 15261860116 | sales@elsa-biotech.com | China | 99 | 55 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Yunpun industrial Co.,Ltd | 21-61726900 15202122459 | sales@yunpun.com | China | 499 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Nanjing KaiMubo Pharmaceutical Co., Ltd. | 025-66162170 | China | 7183 | 55 | |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
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