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Epalrestat

Epalrestat structure

CAS No.: 82159-09-9

Chemical Name:: Epalrestat

Synonyms: 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo;2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid;e)-(e;Eabeth;Epatat;Kinedak;Epa－API;Ipastat;ONO 2235;Epalrest

CBNumber:: CB6312501

Molecular Formula:: C15H13NO3S2

Molecular Weight:: 319.4

MDL Number:: MFCD00865484

MOL File:: 82159-09-9.mol

Last updated:2024-04-24 17:21:45

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Epalrestat Properties

Melting point	210-217 C
Boiling point	516.8±60.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble5mg/mL, clear (warmed)
pka	3.62±0.10(Predicted)
form	powder
color	yellow to orange
Merck	14,3605
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI	InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
InChIKey	CHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILES	S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S
EWG's Food Scores	1
FDA UNII	424DV0807X

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300

Precautionary statements

P264-P270-P301+P310+P330-P405-P501

RIDADR

2811

WGK Germany

RTECS

XJ5131855

HS Code

2932.99.7000

HazardClass

6.1

PackingGroup

NFPA 704

	0
2		0

Epalrestat price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0527	Epalrestat ≥98% (HPLC)	82159-09-9	10mg	$128	2024-03-01	Buy
Sigma-Aldrich	SML0527	Epalrestat ≥98% (HPLC)	82159-09-9	50mg	$496	2024-03-01	Buy
TCI Chemical	E0906	Epalrestat >98.0%(HPLC)(T)	82159-09-9	1g	$135	2024-03-01	Buy
TCI Chemical	E0906	Epalrestat >98.0%(HPLC)(T)	82159-09-9	5g	$337	2024-03-01	Buy
Cayman Chemical	15214	Epalrestat ≥98%	82159-09-9	5mg	$73	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0527	10mg	$128	Buy
SML0527	50mg	$496	Buy
E0906	1g	$135	Buy
E0906	5g	$337	Buy
15214	5mg	$73	Buy

Epalrestat Chemical Properties,Uses,Production

Description

Epalrestat is the second aldose reductase inhibitor to be introduced worldwide and the first to be launched in Japan. The compound is indicated for the treatment of diabetic neuropathy. It is also being investigated for diabetic retinopathy and nephropathy.

Chemical Properties

Red Solid

Originator

Ono (Japan)

Uses

An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.

Uses

Epalrestat has been used as an aldose reductase inhibitor:

in the dahomey larvae diet fed forDrosophila
for non-irradiated and X-ray irradiated human aldose reductase
to test its protective effect in mice with bleomycin-induced pulmonary fibrosis

Uses

Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM

Definition

ChEBI: A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.

brand name

Kinedak

Biochem/physiol Actions

Epalrestat inhibits Aldose Reductase (AR) involved in the rate limiting step in the conversion of glucose to sorbitol under hyperglycemic conditions. Aldose reductase has been the target of multiple clinical investigatons to treat diabetic neuropathy and retinopathy. Epalrestat is an approved drug in Japan and India, used for the treatment of diabetic neuropathy.

References

1) Kikkawa?et al. (1983)?Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235), on peripheral nerve disorders in streptozotocin diabetic rats; Diabetologica,?24?290 2) Terashima?et al. (1984)?Effects of a new aldose reductase inhibitor on various tissues in vitro; J. Pharmacol. Exp. Ther.,?229?226 3) Ramirez and Borja (2008)?Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy; Pharmacotherapy,?28?646

Epalrestat Preparation Products And Raw materials

Raw materials

Concentrated hydrochloric acid Cinnamaldehyde Sodium glycinate Rhodanine-3-acetic acid 1,4-Dioxane

Benzaldehyde Acetic acid Sodium chloroacetate

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Preparation Products

Epalrestat Suppliers

Global( 464)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Shanghai Jinhuan Chemical CO.,LTD.	+86-21-52210535 +8613162045318	sales@jinhchem.com	China	332	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Shanghai Joiny Pharmaceutical Co.,LTD	+8613681955282	gyd@joiny-pharma.com	China	228	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 +8613734021967	kaia@neputrading.com	China	1011	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58

Supplier	Advantage
Alfa Chemistry	58
Shanghai Jinhuan Chemical CO.,LTD.	58
Hebei Mojin Biotechnology Co., Ltd	58
Shanghai Joiny Pharmaceutical Co.,LTD	58
Nantong Guangyuan Chemicl Co,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
Shanxi Naipu Import and Export Co.,Ltd	58
Shanghai Zheyan Biotech Co., Ltd.	58

View Lastest Price from Epalrestat manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	Epalrestat 82159-09-9	US $10.00 / kg	1kg	99.8%	10000ton	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-04-10	(E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid 82159-09-9	US $0.00 / kg	1kg	98%	1000kg	Shanghai Joiny Pharmaceutical Co.,LTD
2024-03-08	Epalrestat 82159-09-9	US $10.00 / kg	1kg	99%	1000kg	Nantong Guangyuan Chemicl Co,Ltd

Epalrestat
82159-09-9
US $10.00 / kg
99.8%
Ouhuang Engineering Materials (Hubei) Co., Ltd

(E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
82159-09-9
US $0.00 / kg
98%
Shanghai Joiny Pharmaceutical Co.,LTD

Epalrestat
82159-09-9
US $10.00 / kg
99%
Nantong Guangyuan Chemicl Co,Ltd

Epalrestat Spectrum

Epalrestat(82159-09-9)MS

82159-09-9(Epalrestat)Related Search:

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Paraquat dichloride Basic Violet 1 Benzothiazole Methanol 1-Phenyl-2-nitropropene

4-oxo-2-mercapto-thiazole-3-acetic acid (intermediate of epalrestat) Brexpiprazole 4-oxo-5-[(2E)-3-phenyl-2-propen-1-ylidene]-2-thioxo-, (5Z)-

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5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet e)-(e EPALRESTAT (e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid AKOS BBS-00007767 OTAVA-BB BB7211260020 Epalrest Epalrestat, 99.5% EPALRESTAT(KINEDAK) 5-[(1Z,2E)-2-METHYL-3-PHENYLPROPENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINEACETICACID(EPALRESTAT) ONO 2235 Epalresta 2-((E)-5-((E)-2-METHYL-3-PHENYLALLYLIDENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)ACETIC ACID Epatrestat 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)- 5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid [5-[(1Z,2E)-2-Methyl-3-phenylallylidene]-4-oxo-2-thioxothiazolidin-3-yl]acetic acid Eabeth Epatat Quinedac Kinedak (E，E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazo-lidineaeetic acid (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid He IpaneMa Division 2-[(5Z)-5[(E)-3-PHENIL-2-METHYLPROP-2-ENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINYL] ACETIC ACID Epalrestat> Epalrestat Epalrestat Epalrestat RS 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)- Epalrestat USP/EP/BP Epalrestat (ONO2235) EpalrestatQ: What is Epalrestat Q: What is the CAS Number of Epalrestat Q: What is the storage condition of Epalrestat Q: What are the applications of Epalrestat Epa－API Ipastat According to Mr He 2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo Antidiabetic API Ipasetam 82159-09-9 81259-09-9 C15H13NO3S2 API Hormone Drugs Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds API's Treatment of diabetic neuropathy 82159-09-9