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4-Hydroxyphenylacetic acid

Description Referrence
4-Hydroxyphenylacetic acid
4-Hydroxyphenylacetic acid structure
Chemical Name:
4-Hydroxyphenylacetic acid
PHPA;NSC 27460;AKOS 236-100;Atenolol Impurity K;RARECHEM AL BO 0188;4-carboxymethylphenol;4-Hydroxyphenylacetic;Arbidol Impurity F HCl;Hydroxyphenylacetic aci;P-HYDROPHENYLACETIC ACID
Molecular Formula:
Formula Weight:
MOL File:

4-Hydroxyphenylacetic acid Properties

Melting point:
148-151 °C(lit.)
Boiling point:
234.6°C (rough estimate)
1.2143 (rough estimate)
refractive index 
1.4945 (estimate)
storage temp. 
Store below +30°C.
Crystalline Powder
White to cream or light tan
2.0-2.4 (30g/l, H2O, 20℃)
Water Solubility 
Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
CAS DataBase Reference
156-38-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetic acid, 4-hydroxy-(156-38-7)
EPA Substance Registry System
Benzeneacetic acid, 4-hydroxy-(156-38-7)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
RTECS  AI2680000
Hazard Note  Irritant
HS Code  29182990
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

4-Hydroxyphenylacetic acid price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H50004 4-Hydroxyphenylacetic acid 98% 156-38-7 5g $20.5 2018-11-13 Buy
Sigma-Aldrich H50004 4-Hydroxyphenylacetic acid 98% 156-38-7 25g $39.1 2018-11-13 Buy
TCI Chemical H0290 4-Hydroxyphenylacetic Acid >99.0%(GC)(T) 156-38-7 25g $18 2018-11-22 Buy
TCI Chemical H0290 4-Hydroxyphenylacetic Acid >99.0%(GC)(T) 156-38-7 100g $48 2018-11-22 Buy
Alfa Aesar A15018 4-Hydroxyphenylacetic acid, 99% 156-38-7 25g $35.6 2018-11-13 Buy

4-Hydroxyphenylacetic acid Chemical Properties,Uses,Production


4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid.


  1. Liu, Zhongyang, et al. "4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84.
  2. Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115. 
  3. Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825.

Chemical Properties

white to cream or light tan crystalline powder


A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.


ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.

Purification Methods

Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]

4-Hydroxyphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

4-Hydroxyphenylacetic acid Suppliers

Global( 345)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19947 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3210 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22064 58
Dalian Richfortune Chemicals Co., Ltd
86-411-84820922, 84821539
86-411-84821380 China 362 57
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32606 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897 CHINA 2236 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24093 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20177 58
Accela ChemBio Inc.
(+1)-858-876-1948 United States 12233 58

View Lastest Price from 4-Hydroxyphenylacetic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-26 4-Hydroxyphenylacetic acid
US $100.00 / KG 1KG 99% Customized career henan chemical co

4-Hydroxyphenylacetic acid Spectrum

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