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4-Hydroxyphenylacetic acid

Description Referrence
4-Hydroxyphenylacetic acid
4-Hydroxyphenylacetic acid
CAS No.
156-38-7
Chemical Name:
4-Hydroxyphenylacetic acid
Synonyms
PHPA;NSC 27460;AKOS 236-100;RARECHEM AL BO 0188;4-carboxymethylphenol;4-Hydroxyphenylacetic;Arbidol Impurity F HCl;Hydroxyphenylacetic aci;P-HYDROPHENYLACETIC ACID;4-Hdroxyphenylacetic acid
CBNumber:
CB6314323
Molecular Formula:
C8H8O3
Formula Weight:
152.15
MOL File:
156-38-7.mol

4-Hydroxyphenylacetic acid Properties

Melting point:
148-151 °C(lit.)
Boiling point:
234.6°C (rough estimate)
Density 
1.2143 (rough estimate)
refractive index 
1.4945 (estimate)
storage temp. 
Store below +30°C.
solubility 
50g/l
form 
Crystalline Powder
color 
White to cream or light tan
PH
2.0-2.4 (30g/l, H2O, 20℃)
Water Solubility 
Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
BRN 
1448766
CAS DataBase Reference
156-38-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetic acid, 4-hydroxy-(156-38-7)
EPA Substance Registry System
Benzeneacetic acid, 4-hydroxy-(156-38-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
RTECS  AI2680000
Hazard Note  Irritant
TSCA  Yes
HS Code  29182990
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

4-Hydroxyphenylacetic acid price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H50004 4-Hydroxyphenylacetic acid 98% 156-38-7 5g $20.5 2018-11-13 Buy
Sigma-Aldrich H50004 4-Hydroxyphenylacetic acid 98% 156-38-7 25g $39.1 2018-11-13 Buy
TCI Chemical H0290 4-Hydroxyphenylacetic Acid >99.0%(GC)(T) 156-38-7 25g $18 2018-11-22 Buy
TCI Chemical H0290 4-Hydroxyphenylacetic Acid >99.0%(GC)(T) 156-38-7 100g $48 2018-11-22 Buy
Alfa Aesar A15018 4-Hydroxyphenylacetic acid, 99% 156-38-7 25g $35.6 2018-11-13 Buy

4-Hydroxyphenylacetic acid Chemical Properties,Uses,Production

Description

4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid.

Referrence

  1. Liu, Zhongyang, et al. "4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84.
  2. Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115. 
  3. Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825.

Chemical Properties

white to cream or light tan crystalline powder

Uses

A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.

Purification Methods

Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]

4-Hydroxyphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products


4-Hydroxyphenylacetic acid Suppliers

Global( 330)Suppliers
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Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19957 60
Shenzhen Sendi Biotechnology Co.Ltd.
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0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
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info@dakenchem.com CHINA 22080 58
Dalian Richfortune Chemicals Co., Ltd
86-411-84820922, 84821539
86-411-84821380 sales@richfortunechem.com China 416 57
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
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+86-0592-6210733 sales@mainchem.com CHINA 32764 55
career henan chemical co
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sales@coreychem.com CHINA 10944 58
Taizhou Sunny Chemical Co.,Ltd +86-523-86920899 13951172783
+86-523-86926789 sales@suningchemical.com jwhua@suningchemical.com China 13 62
Shanghai Billion Chemical Chemical Co. Ltd. 021-58771921 13818686088(wechat)
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J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from 4-Hydroxyphenylacetic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-26 4-Hydroxyphenylacetic acid
156-38-7
US $100.00 / KG 1KG 99% Customized

4-Hydroxyphenylacetic acid Spectrum


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