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4-Hydroxyphenylacetic acid

Description Referrence
4-Hydroxyphenylacetic acid
4-Hydroxyphenylacetic acid structure
CAS No.
156-38-7
Chemical Name:
4-Hydroxyphenylacetic acid
Synonyms
PHPA;NSC 27460;AKOS 236-100;RARECHEM AL BO 0188;Atenolol Impurity K;Atenolol Impurity 12;4-carboxymethylphenol;4-Hydroxyphenylacetic;Arbidol Impurity F HCl;Hydroxyphenylacetic aci
CBNumber:
CB6314323
Molecular Formula:
C8H8O3
Formula Weight:
152.15
MOL File:
156-38-7.mol

4-Hydroxyphenylacetic acid Properties

Melting point:
148-151 °C(lit.)
Boiling point:
234.6°C (rough estimate)
Density 
1.2143 (rough estimate)
refractive index 
1.4945 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
50g/l
form 
Crystalline Powder
pka
4.50±0.10(Predicted)
color 
White to cream or light tan
PH
2.0-2.4 (30g/l, H2O, 20℃)
Water Solubility 
Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
BRN 
1448766
InChIKey
XQXPVVBIMDBYFF-UHFFFAOYSA-N
CAS DataBase Reference
156-38-7(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
3J9SHG0RCN
NIST Chemistry Reference
Benzeneacetic acid, 4-hydroxy-(156-38-7)
EPA Substance Registry System
Benzeneacetic acid, 4-hydroxy- (156-38-7)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280a-P304+P340-P405-P501a-P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
RTECS  AI2680000
Hazard Note  Irritant
TSCA  Yes
HS Code  29182990
NFPA 704
1
2 0

4-Hydroxyphenylacetic acid price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H50004 4-Hydroxyphenylacetic acid 98% 156-38-7 5g $22.2 2021-03-22 Buy
Sigma-Aldrich H50004 4-Hydroxyphenylacetic acid 98% 156-38-7 25g $41.4 2021-03-22 Buy
TCI Chemical H0290 4-Hydroxyphenylacetic Acid >99.0%(GC)(T) 156-38-7 25g $20 2021-03-22 Buy
TCI Chemical H0290 4-Hydroxyphenylacetic Acid >99.0%(GC)(T) 156-38-7 100g $51 2021-03-22 Buy
Alfa Aesar A15018 4-Hydroxyphenylacetic acid, 99% 156-38-7 25g $39.6 2021-03-22 Buy

4-Hydroxyphenylacetic acid Chemical Properties,Uses,Production

Description

4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid.

Referrence

  1. Liu, Zhongyang, et al. "4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84.
  2. Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115. 
  3. Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825.

Chemical Properties

white to cream or light tan crystalline powder

Uses

A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.

Purification Methods

Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]

4-Hydroxyphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products


4-Hydroxyphenylacetic acid Suppliers

Global( 499)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
CE Pharm Co.,Ltd
+86 13816833708
binbin.lin@cepharm.cn CHINA 52 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Dalian Richfortune Chemicals Co., Ltd
0411-84820922
86-411-84821380 sales@richfortunechem.com China 300 57
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1010 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3004 58

View Lastest Price from 4-Hydroxyphenylacetic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-21 4-Hydroxyphenylacetic acid
156-38-7
US $1.00-89.00 / KG 0.5KG >99% 20tons Anhui Rencheng Technology Co., Ltd
2021-07-13 4-Hydroxyphenylacetic acid
156-38-7
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09 4-Hydroxyphenylacetic acid
156-38-7
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

4-Hydroxyphenylacetic acid Spectrum


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