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GSK484

GSK484 Structure
GSK484 structure
CAS No.
1652591-81-5
Chemical Name:
GSK484
Synonyms
GSK484;CS-2265;AOB6992;GTPL8577;GSK484 HCl;GSK484 >=98% (HPLC);PAD4 inhibitor GS484;PAD4 inhibitor GSK484;GSK484 (hydrochloride);GSK484 hydrochloride,GSK 484,Protein Arginine Deiminase,GSK-484,GSK-484 hydrochloride,GSK484,inhibit,Peptidylarginine Deiminase,Inhibitor
CBNumber:
CB63146499
Molecular Formula:
C27H32ClN5O3
Molecular Weight:
510.04
MDL Number:
MOL File:
1652591-81-5.mol
Last updated:2024-04-17 13:57:11
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GSK484 Properties

storage temp. 2-8°C
solubility DMSO:25.0(Max Conc. mg/mL);49.01(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);49.01(Max Conc. mM)
PBS buffer (pH 7.2):5.0(Max Conc. mg/mL);9.8(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.82(Max Conc. mM)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990

GSK484 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1658 GSK484 ≥98% (HPLC) 1652591-81-5 5MG $346 2023-06-20 Buy
Sigma-Aldrich SML1658 GSK484 ≥98% (HPLC) 1652591-81-5 25MG $1350 2023-06-20 Buy
Cayman Chemical 17488 GSK484 (hydrochloride) ≥95% 1652591-81-5 500μg $37 2024-03-01 Buy
Cayman Chemical 17488 GSK484 (hydrochloride) ≥95% 1652591-81-5 1mg $68 2024-03-01 Buy
Cayman Chemical 17488 GSK484 (hydrochloride) ≥95% 1652591-81-5 5mg $283 2024-03-01 Buy
Product number Packaging Price Buy
SML1658 5MG $346 Buy
SML1658 25MG $1350 Buy
17488 500μg $37 Buy
17488 1mg $68 Buy
17488 5mg $283 Buy

GSK484 Chemical Properties,Uses,Production

Description

GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils. It exhibits favorable pharmacokinetic profiles in mouse and rat. See the Structural Genomics Consortium (SGC) website for more information.

Uses

GSK484 is a novel selective PAD4 inhibitor.

Biochem/physiol Actions

GSK484 is a potent selective reversible inhibitor of protein arginine deiminase PAD4, an enzyme believed to play a role in granulocyte and macrophage development leading to inflammation and immune response, and overexpressed in many tumors. GSK484 has IC50 values of 50 nM without calcium and 250 nM in the presence of 2 mM calcium. GSK484 showed minimal off-target activity tested against 50 other proteins with no activation across HDACs 1–11 even at 100 μM. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is reordered to form a β-hairpin. For full characterization details, please visit the GSK484 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

GSK484 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK484 Suppliers

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Chuchang Biotech Co., Ltd. 		+86-18727130788 +86-18727130788 info@chuchangbiotech.com China 100 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028 kathy@hbyinsheng.com China 3582 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Supplier Advantage
Hubei Chuchang Biotech Co., Ltd. 		58
ATK CHEMICAL COMPANY LIMITED 		60
Career Henan Chemica Co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Hebei Miaoyin Technology Co.,Ltd 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58

View Lastest Price from GSK484 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSK484 (hydrochloride) pictures 2024-04-19 GSK484 (hydrochloride)
1652591-81-5
 US $0.00-0.00 / mg 1mg 98% 100G Hubei Chuchang Biotech Co., Ltd.

1652591-81-5(GSK484)Related Search:

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GSK484 GSK484 (hydrochloride) CS-2265 PAD4 inhibitor GS484 GSK484 HCl ((3S,4R)-3-amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride AOB6992 GTPL8577 GSK484 >=98% (HPLC) PAD4 inhibitor GSK484 GSK484 hydrochloride,GSK 484,Protein Arginine Deiminase,GSK-484,GSK-484 hydrochloride,GSK484,inhibit,Peptidylarginine Deiminase,Inhibitor 1652591-81-5 652591-81-5 C27H31N5O3ClH