GQ-16
- CAS No.
- 870554-67-9
- Chemical Name:
- GQ-16
- Synonyms
- GQ-16;GQ-16 Exclusive;5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-, (5Z)-;(5Z)-5-[(5-bromo-2-methoxyphenyl)methylidene]-3-[(4-methylphenyl)methyl]-1,3-thiazolidine-2,4-dione;PPAR,Inhibitor,reduced adipogenic actions,PPARγ,GQ-16,insulin sensitization,inhibit,Peroxisome proliferator-activated receptors,insulin Resistance,GQ16,GQ 16
- CBNumber:
- CB63152621
- Molecular Formula:
- C19H16BrNO3S
- Molecular Weight:
- 418.3
- MDL Number:
- MOL File:
- 870554-67-9.mol
GQ-16 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11908 | GQ-16 ≥98% | 870554-67-9 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 11908 | GQ-16 ≥98% | 870554-67-9 | 10mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 11908 | GQ-16 ≥98% | 870554-67-9 | 50mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 11908 | GQ-16 ≥98% | 870554-67-9 | 100mg | $426 | 2024-03-01 | Buy |
| ApexBio Technology | C3407 | GQ-16 | 870554-67-9 | 100mg | $485 | 2021-12-16 | Buy |
GQ-16 Chemical Properties,Uses,Production
Description
Full activation of peroxisome proliferator-
in vitro
gq-16 was an effective inhibitor of cdk5-mediated phosphorylation of pparγ, exhibiting a ki value of 160 nm. gq-16 was specific for pparγ and possessed no detectable activity when tested for the ability to activate other ppar subtypes (pparα or pparβ/δ) or rxrα. in both nih-3t3 and c3h10t1/2 cell models with established pparγ-dependent adipogenesis, gq-16 displayed reduced the potential of adipogenic [1].
in vivo
in the mouse model of diet-induced obesity and insulin resistance, administration of gq-16 (20 mg/kg/day) by oral gavage daily blocked hfd-dependent effects on intracellular inflammatory pathways and improved insulin sensitivity. gq-16 did not elicit increased weight gain [1].
References
[1] amato a a, rajagopalan s, lin j z, et al. gq-16, a novel peroxisome proliferator-activated receptor γ (pparγ) ligand, promotes insulin sensitization without weight gain[j]. journal of biological chemistry, 2012, 287(33): 28169-28179.
GQ-16 Preparation Products And Raw materials
Raw materials
Preparation Products
GQ-16 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4984 | 55 |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 9609 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 61720 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2853979810@qq.com | China | 9879 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2490 | 58 |