UMB-32
- CAS No.
- 1635437-39-6
- Chemical Name:
- UMB-32
- Synonyms
- UMB-32;Imidazo[1,2-a]pyrazin-3-amine, N-(1,1-dimethylethyl)-2-[4-(3,5-dimethyl-4-isoxazolyl)phenyl]-
- CBNumber:
- CB63152757
- Molecular Formula:
- C21H23N5O
- Molecular Weight:
- 361.44
- MDL Number:
- MFCD32645114
- MOL File:
- 1635437-39-6.mol
UMB-32 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17123 | UMB-32 ≥98% | 1635437-39-6 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 17123 | UMB-32 ≥98% | 1635437-39-6 | 5mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 17123 | UMB-32 ≥98% | 1635437-39-6 | 10mg | $380 | 2024-03-01 | Buy |
| Cayman Chemical | 17123 | UMB-32 ≥98% | 1635437-39-6 | 25mg | $830 | 2024-03-01 | Buy |
| TRC | U700940 | UMB-32 | 1635437-39-6 | 1mg | $50 | 2021-12-16 | Buy |
UMB-32 Chemical Properties,Uses,Production
Uses
UMB-32 is a novel and potent BET bromodomain (BRD4) inhibitor.
Biological Activity
umb-32 is a potent, selective inhibitor of the bet bromodomain brd4 [1]. the bet family (brd2, brd3, brd4, and brdt) functions as transcriptional coactivator proteins. bet bromodomains are also important mediators of cell cycle progression and facilitate developmental transitions such as spermiogenesis. deregulation of bet bromodomain function has been observed in numerous malignancies. bet bromodomain inhibition has contributed new insights into gene regulation and emerged as a promising therapeutic strategy in cancer [1].
in vitro
umb-32 bound to brd4 with a kd value of 550 nm and 724 nm cellular potency in brd4-dependent lines. umb-32 showed potency against taf1, a bromodomain-containing transcription factor. umb-32 showed markedly increased potency for the bet proteins associated with a dramatic improvement in selectivity. umb-32 potently bound to the taf1 and taf1l with the kd values of 560nm and 1.3 μm, respectively [1].
References
[1] mckeown m r, shaw d l, fu h, et al. biased multicomponent reactions to develop novel bromodomain inhibitors[j]. journal of medicinal chemistry, 2014, 57(21): 9019-9027.
UMB-32 Preparation Products And Raw materials
Raw materials
Preparation Products
UMB-32 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |