ChemicalBook >> CAS DataBase List >>(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
- CAS No.
- 1448189-80-7
- Chemical Name:
- (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
- Synonyms
- VHL Ligand 1;ULM-1;ULM-1(MDK7526HCL);VHL Ligand 1 HCl salt;141003;CS-2718;ULM-1 HCl;UBI-10003;MDK7526 HCl;MDK-7526;ULM-1
- CBNumber:
- CB63156669
- Molecular Formula:
- C22H31ClN4O3S
- Molecular Weight:
- 467.03
- MDL Number:
- MOL File:
- 1448189-80-7.mol
- MSDS File:
- SDS
Last updated:2024-04-01 18:08:31
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Properties
| storage temp. | 2-8°C |
|---|---|
| solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| InChIKey | JYRTWGCWUBURGU-XIMRXPCLNA-N |
| SMILES | C([C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)(=O)NCC1C=CC(C2=C(N=CS2)C)=CC=1.Cl |&1:1,3,9,r| |
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 901490 | (S,R,S)-AHPC hydrochloride ≥97% | 1448189-80-7 | 100MG | $522 | 2023-06-20 | Buy |
| Cayman Chemical | 21591 | VHL Ligand 1 (hydrochloride) ≥95% | 1448189-80-7 | 10mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 21591 | VHL Ligand 1 (hydrochloride) ≥95% | 1448189-80-7 | 25mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 21591 | VHL Ligand 1 (hydrochloride) ≥95% | 1448189-80-7 | 50mg | $249 | 2024-03-01 | Buy |
| Cayman Chemical | 21591 | VHL Ligand 1 (hydrochloride) ≥95% | 1448189-80-7 | 100mg | $353 | 2024-03-01 | Buy |
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Chemical Properties,Uses,Production
Description
VHL ligand 1 is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). It is the von Hippel-Lindau (VHL) E3 ligase binding portion of some VHL-based PROTACs, including BET PROTAC MZ1 (Item No. 21622).
Uses
(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Hydrochloride acts as a reagent in the synthesis of PROTAC compounds that mediated the degration of oncogenic c-ABL and BCR-ABL.
Uses
(S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487) used as a negative control.
Synthesis of (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride from tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 139)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Origin Specialty Chemicals Co., Ltd. | +86-512-68662322 +86-17312436797 | hanqun@origsc.com | China | 733 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 338 | 58 |
| Shanghai finete Pharmaceutical Co., Ltd. | +86-18221039705 | CHINA | 139 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
View Lastest Price from (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-07 | (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
1448189-80-7
|
US $0.00-0.00 / kg | 0.1kg | >98% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
 |
2024-04-02 | (S,R,S)-AHPC hydrochloride
1448189-80-7
|
US $0.00 / g | 10g | >95.00% | 10g | Xian confluore Biological Technology Co., Ltd. | |
 |
2024-03-28 | MDK-7526 HCl
1448189-80-7
|
US $0.00 / kg | 25kg | 98%-99% | Inquiry | PNP Biotech Co. Ltd |
-
- (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
1448189-80-7
- US $0.00-0.00 / kg
- >98%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- (S,R,S)-AHPC hydrochloride
1448189-80-7
- US $0.00 / g
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
-
- MDK-7526 HCl
1448189-80-7
- US $0.00 / kg
- 98%-99%
- PNP Biotech Co. Ltd
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Spectrum
1448189-80-7((2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride)Related Search:
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Protein degrader 1 (hydrochloride)
(S,R,S)-AHPC hydrochloride
MDK-7526;ULM-1
(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide hydrochloride
Protein degrader 1
141003
(2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide hydrochloride
CS-2718
Degradation Inducing Moiety A
PROTEIN DEGRADER 1 HYDROCHLORIDE; MDK7526 HCL; MDK7526; MDK-7526; MDK 7526; VHL LIGAND 1; ULM-1; VH032 DESACETYL HYDROCHLORIDE; VH032 AMINE HCL; DEGRADATION INDUCING MOIETY A;
VH032 amine HCl
VH032 desacetyl Hydrochloride
MDK7526 HCl
(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine
VHL Ligand 1 (hydrochloride)
PROTAC-VHL-Ligand 1
ULM-1 HCl
PROTAC-VHL-ligand hydrochloride
(S,R,S)-AHPC hydrochloride >=97%
MDK7526(Protein degrader 1)
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride ISO 9001：2015 REACH
VH032-NH2 hydrochloride
VHL ligand 1 hydrochlorid
Protein degrader 1 HCl)
ULM-1HCl (MDK7526 HCl
ULM-1
VHL Ligand 1
ULM-1(MDK7526HCL)
VHL Ligand 1 HCl salt
UBI-10003
(S,R,S)-AHPC (VH032-NH2) hydrochloride
L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-, HCl
(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, E3 Ligase ligand, Ligand for PROTAC? research, VH032
(S,R,S)-AHPC (monohydrochloride)
1448189-80-7