Cibinetide
- CAS No.
- 1208243-50-8
- Chemical Name:
- Cibinetide
- Synonyms
- ARA290;Cibinetide;ARA290, >98%;ara290/Poziotinib;ARA209(Cibinetide);Cibinetide Acetate;ARA-290 (Cibinetide);ARA290,Cibinetide, >98%;WZTIQQBMSJTRBR-MUZUOSMHSA-N;ARA-290(Cibinetide) acetate
- CBNumber:
- CB63159958
- Molecular Formula:
- C51H84N16O21
- Molecular Weight:
- 1257.31
- MDL Number:
- MFCD30534405
- MOL File:
- 1208243-50-8.mol
| Density | 1.56±0.1 g/cm3(Predicted) |
|---|---|
| pka | 2.90±0.10(Predicted) |
| Sequence | Glp-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| InChIKey | WZTIQQBMSJTRBR-WYKNNRPVSA-N |
| FDA UNII | 9W5677JKDA |
Cibinetide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb611396 | ARA-290 | 1208243-50-8 | 5mg | $1043.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611396 | ARA-290 | 1208243-50-8 | 10mg | $1802 | 2021-12-16 | Buy |
| DC Chemicals | DC22493 | ARA-290(Cibinetide) >98% | 1208243-50-8 | 100mg | $950 | 2021-12-16 | Buy |
Cibinetide Chemical Properties,Uses,Production
Description
Cibinetide, also known as ARA-290, is a synthetic 11-mer peptide that binds the tissue-protective receptor. ARA290 inhibits high glucose-induced apoptosis of NRK-52E cells. Cibinetide Protects Isolated Human Islets in a Stressful Environment and Improves Engraftment in the Perspective of Intra Portal Islet Transplantation. Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain. ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception.
benefits
Cibinetide, also known as ARA 290 and helix B surface peptide (HBSP), is a synthetic 11 amino acid peptide derived from the structure of the B helix of erythropoietin(EPO), with marked anti-apoptotic, anti-inflammatory and anti-permeability effects, recapitulating the effects of the endogenous EPO. Unlike EPO, is not haematopoietic and, thus, is free of the possible side effects of EPO, which can be life threatening. In an experimental model of DR, cibinetide administered systemically inhibited vascular leakage and edema and protected against retinal blood vessels and neuroglial degeneration. Additionally, cibinetide improved metabolic control in both preclinical and clinical studies[7].
Biological Activity
Cibinetide (ARA 290) is an engineered peptide that mimics the 3 dimensional structure of the helix B surface domain of erythropoietin (EPO). It is designed to bind selectively to the non-hematopoietic EPO receptor (sometimes referred to as the innate repair receptor or IRR), that is believed to be a heterodimer of EPOR and the cytokine family beta common receptor (βCR, CD131). Non-hematopoietic EPO ligands have potential tissue protective and anti-inflammatory actions. The IRR is suggested to be a point of integration between the immune system and pain signalling (via nociception) .
in vitro
Cibinetide (ARA290) enhances the proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs)[1]. Cibinetide (ARA290) is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic and antidepressant effects.
References
[1] YAOMING. Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand.[J]. Transplantation, 2020. DOI:10.1097/TP.0000000000003284.
[2] AWIDAZAMZAM. The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice.[J]. International Journal of Molecular Sciences, 2021. DOI:10.3390/ijms23010055.
[3] LOISNOEMI. A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema.[J]. Journal of Clinical Medicine, 2020. DOI:10.3390/jcm9072225.
[4] NAIRZMANFRED. Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.[J]. Scientific Reports, 2017. DOI:10.1038/s41598-017-13046-3.
[5] BRINESMICHAEL CeramiAnthony. The receptor that tames the innate immune response.[J]. Molecular Medicine, 2012. DOI:10.2119/molmed.2011.00414.
[6] BRINESMICHAEL CeramiAnthony. Erythropoietin and engineered innate repair activators.[J]. Methods in molecular biology, 2013. DOI:10.1007/978-1-62703-308-4_1.
[7] Noemi Lois. “A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema.” Journal of Clinical Medicine (2020).
Cibinetide Preparation Products And Raw materials
Raw materials
Preparation Products
Cibinetide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Tai Hui Biotechnology Co., Ltd | +86-18224031330 +86-18081096520 | 404435307@qq.com | China | 23 | 58 |
| Shanghai Yunao International Trade Co., Ltd | +8617621705551 | asdf@shanghaihg.cn | China | 265 | 58 |
| zhuzhou dingcheng meihei comestic co.,ltd | +undefined18873369619 | dingchengbusiness8@163.com | China | 241 | 58 |
| Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 | sale01@hbweimiao.com | China | 71 | 58 |
| Hebei Xunou new energy Technology Co., LTD | +undefined17531957005 | xunou8@hbxunou.com | China | 36 | 58 |
| Shanghai Chinqesen Biotechnology Co., Ltd. | +86-16628886292 +86-19521323435 | sales2@qschem-pharma.com | China | 46 | 58 |
| Anhui Yiao New Material Technology Co., Ltd | +86-199-55145978 +8619955145978 | sales8@anhuiyiao.com | China | 253 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
View Lastest Price from Cibinetide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | ARA-290
1208243-50-8
|
US $6.20-5.50 / vials | 10vials | 99% | 1000vials | Wuhan Cell Pharmaceutical Co., Ltd | |
 |
2024-04-24 | ARA 290
1208243-50-8
|
US $35.00 / Box | 1Box | 99.99% | 10000000000 | zhuzhou dingcheng meihei comestic co.,ltd | |
 |
2024-04-24 | ARA 290
1208243-50-8
|
US $30.00 / Box | 1Box | 99.99% | 10000000000 | zhuzhou dingcheng meihei comestic co.,ltd |