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Pravastatin

New Hypolipidemic drugs Pharmacological action Pharmacokinetics Adverse reaction Precaution
Pravastatin
Pravastatin
CAS No.
81093-37-0
Chemical Name:
Pravastatin
Synonyms
ELISOR;KOPOSTAT;PRAVACHOL;MEVALOTIN;Pravatatin;PRAVASTATIN;PRAVASELECT;Pravastatin-D9;PRAVASTATIN(RG);EPTASTATIN SODIUM
CBNumber:
CB6317122
Molecular Formula:
C23H36O7
Formula Weight:
424.53
MOL File:
81093-37-0.mol

Pravastatin Properties

Melting point:
171.2-173 °C
storage temp. 
2-8°C
solubility 
H2O: 19 mg/mL
form 
powder
color 
white
CAS DataBase Reference
81093-37-0(CAS DataBase Reference)

SAFETY

Hazard Codes  F,C
Risk Statements  11-34
Safety Statements  16-26-36/37/39-45
WGK Germany  2
RTECS  QJ7185000

Pravastatin price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10010342 Pravastatin ≥98% 81093-37-0 10mg $29 2018-11-19 Buy
Cayman Chemical 10010342 Pravastatin ≥98% 81093-37-0 25mg $65 2018-11-19 Buy
Cayman Chemical 10010342 Pravastatin ≥98% 81093-37-0 50mg $109 2018-11-19 Buy
Cayman Chemical 10010342 Pravastatin ≥98% 81093-37-0 100mg $189 2018-11-19 Buy

Pravastatin Chemical Properties,Uses,Production

New Hypolipidemic drugs

Pravastatin is a derivative of Vastatin. It is a new type of hypolipidemic drug. It is especially suitable for primary hypercholesterolemia which is still not controlled by dietary restriction. The drug is statins, developed by Japan Sankyo Pharmaceutical Co. Ltd. and AmericanBristo1-Myers Sguibb Company. It was listed in Japan for the first time in 1989. It is a new drug of Category 4 of western medicine in China, which has a broad market prospect.

Pharmacological action

  • Pravastatin is a cholesterol lowering drug and is a competitive inhibitor of the Hydroxymethyl glutaryl coenzyme A reductaseh (HMG-CoA reductase). The mechanism of action is the same with lovastatin. It can inhibit the synthesis of cholesterol, increase the metabolism of low density lipoprotein (LDL) and reduce the cholesterol. It can also increase the high density lipoprotein (HDL) and reduce triglyceride. The efficacy of this product is the same as lovastatin and statins. It is used for heterozygous familial, non familial hypercholesterolemia and mixed hyperlipidemia, familial hyperlipoproteinemia type III and serum hypertriglyceridemia (type IV).
  • Pravastatin is an open - ring active substance, and its sodium salt is used clinically. Like other statins, this product competitively inhibits HMG-CoA reductase, reduces serum TC, LDL-C and ApoB, also decreases serum VLDL and TG, and increases HDLC and Apo-A, which is similar to lovastatin.

Pharmacokinetics

This product is absorbed orally, and its bioavailability is about 17%. The concentration of the blood drug peak is reached 1 to 1.5 hours after taking the medicine. It can be selectively distributed in liver cells. It is metabolized in the liver, the active metabolite is TK 2.5% ~ 10%. It excretes rapidly. After one oral administration, 20% and 71% is discharged through urine and feces within 96 hours. The half-life is 1.5 to 2 hours.

Adverse reaction

The occasional adverse reaction includes diarrhea, abdominal pain, and gastrointestinal discomfort as well as the rise of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, gamma glutamyl transpeptidase. Other occasional adverse reaction includes the increase of CPK and urea nitrogen and the phenomenon of urine occult blood.

Precaution

  1. The curative effect of homozygous family hypercholesterolemia is poor. During the treatment, the liver function should be checked regularly. If the increase of SGPT and SGOT is equal to or more than three times the normal upper limit and is persistent, the treatment should be stopped. Patients with the history of liver disease or drinking history should be careful in use.
  2. The use of HMG-COA reductase inhibitor class lipid lowering drugs can cause the increase of CPK. If the rise value is 10 times the normal limit, it should be stopped. In the course of use, if the patient has unexplained myalgia, pain, weakness, especially those with discomfort and fever, they should be reported to the doctor immediately.
  3. Other HMG-COA reductase inhibitors such as cyclosporin, fibrinic acid derivatives, nicotinic acid, etc. can increase the incidence of myositis and myopathy.However, if pravastatin is used simultaneously with the above drugs, clinical trials indicates that the incidence of myositis and myopathy will not be increased.

Chemical Properties

Off-white Cryst

Uses

antiglaucoma,

Uses

anti-hyperlipoproteinemic, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor

brand name

Pravachol (Bristol-Myers Squibb).

Pravastatin Preparation Products And Raw materials

Raw materials

Preparation Products


Pravastatin Suppliers

Global( 112)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001
peter@hubeijusheng.com CHINA 18004 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
001-617-206-9595 sales@chemreagents.com United States 9943 62
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1954 70
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202,021-54308259
+86-21-54291107 info@hanhonggroup.com China 43389 64
Syntechem Co.,Ltd Please Email
E-Mail Inquiry info@syntechem.com China 13074 57
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12388 58
MedChemexpress LLC 609-228-6898
609-228-5909 sales@medchemexpress.com United States 4618 58

81093-37-0(Pravastatin)Related Search:


  • PRAVASTATIN FREE BASE
  • Pravatatin
  • (3R,5R)-7-[(1S,2R,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoic acid
  • PRAVASTATIN(RG)
  • 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-b,d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, [1S-[1a(bS*,dS*),2a,6a,8b(R*),8aa]]-
  • 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-b,d,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, (bR,dR,1S,2S,6S,8S,8aR)- (9CI)
  • 3b-Hydroxycompactin
  • 3β-Hydroxycompactin Sodium salt
  • sodium(+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8αR)-6-hydroxy-2-methyl-8-[(S)-2-methyl-hutyryloxy]1,2,6,7,8,8α-hexahydro-1-naphthyl]heptanoate
  • (1S,βR,δR,8aβ)-1,2,6,7,8,8a-Hexahydro-β,δ,6β-trihydroxy-2β-methyl-8α-[(S)-2-methyl-1-oxobutoxy]-1β-naphthaleneheptanoic acid
  • Pravastatin-D9
  • (3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-Methyl-8-(((S)-2-Methylbutanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid
  • 81131-76-6
  • C23H36O7
  • PRAVASTATIN
  • PRAVACHOL
  • PRAVASELECT
  • ELISOR
  • EPTASTATIN SODIUM
  • (BETA R,DELTA R,1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-HEXAHYDRO-BETA,DELTA,6-TRIHYDROXY-2-METHYL-8-[(2S)-2-METHYL-1-OXOBUTOXY]-1-NAPHTHALENEHEPTANOIC ACID MONOSODIUM SALT
  • (BETAR, DELTAR,1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-HEXAHYDRO-BETA, DELTA,6-TRIHYDROXY-2-METHYL-8[(2S)-2-METHYL-1-OXOBUTOXYL]-1-NAPHTHALENEHEPTANOIC ACID SODIUM
  • (BETA-R,DELTA-R,1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-HEXAHYDRO-BETA,DELTA,6-TRIHYDROXY-2-METHYL-8[(2S)-2-METHYL-1-OXOBUTOXYL]-1-NAPHTHALENEHEPTANOIC ACID NA
  • MEVALOTIN
  • KOPOSTAT
  • [1s-[1a(bs,ds),2a,6b,8b(r),8aa]]-1,2,6,7,8,8a-hexahydro-b,d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid monosodium salt
  • (+)-(3r,5r)-3,5-dihydroxy-7-[(1s,2s,6s,8s,8ar)-6-hydroxy-2-methyl-8-[(s)-2-methylbutyryloxy]-1,2,6,7,8,8a-hexahydro-1-naphthyl]-heptanoic acid
  • 3BETA-HYDROXYCOMPACTIN, NA
  • 81093-37-0
  • Selektine
  • D to K
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Hydroxymethylglutaryl-CoA Reductase
  • Biochemicals and Reagents
  • BioChemical
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