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AZD2098

CAS No.
566203-88-1
Chemical Name:
AZD2098
Synonyms
AZD2098;AZD 2098 NEW;AZD-2098 >=98% (HPLC);AZD 2098;AZD-2098;AZD2098;2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide;Benzenesulfonamide, 2,3-dichloro-N-(3-methoxy-2-pyrazinyl)-;AZD-2098,inhibit,CC chemokine receptor,CCR,Inhibitor,AZD2098,AZD 2098
CBNumber:
CB63175527
Molecular Formula:
C11H9Cl2N3O3S
Molecular Weight:
334.18
MDL Number:
MFCD31382158
MOL File:
566203-88-1.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

AZD2098 Properties

Melting point 185-186°C
Boiling point 489.3±55.0 °C(Predicted)
Density 1.569±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO (>25 mg/ml)
pka 5.56±0.40(Predicted)
form powder
color white to beige
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

AZD2098 price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2272 AZD-2098 ≥98% (HPLC) 566203-88-1 5mg $102 2024-03-01 Buy
Sigma-Aldrich SML2272 AZD-2098 ≥98% (HPLC) 566203-88-1 25mg $411 2024-03-01 Buy
Cayman Chemical 27633 AZD 2098 566203-88-1 5mg $93 2024-03-01 Buy
Cayman Chemical 27633 AZD 2098 566203-88-1 25mg $381 2024-03-01 Buy
Cayman Chemical 27633 AZD 2098 566203-88-1 1mg $32 2024-03-01 Buy
Product number Packaging Price Buy
SML2272 5mg $102 Buy
SML2272 25mg $411 Buy
27633 5mg $93 Buy
27633 25mg $381 Buy
27633 1mg $32 Buy

AZD2098 Chemical Properties,Uses,Production

Description

AZD-2098 (566203-88-1) is a potent, orally bioavailable antagonist of CCR4 (pIC50 = 7.8(h), 8.0(r), 8.0(m), 7.6(d)).1 Inactive at CXCR1/2, CCR1, CCR2b, CCR5, CCR7, and CCR8 @ 10 μM.

Uses

AZD-2098 is a potent and selective agonist of CCR4 chemokine receptor with IC50 values ranging from 10 to 25 nM across different species. CCR4 is involved in activation and migration of Th2 lymphocytes to the lungs in response to allergens. Treating sensitised rats results in reduced inflammation of lung tissue.

Biochem/physiol Actions

AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ~120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge).

storage

Store at +4°C

References

Kindon et al. (2017), Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists; ACS Med. Chem. Lett. 8 981

AZD2098 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 53)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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Career Henan Chemica Co
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InvivoChem
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Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266 China 4121 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
AZD2098 AZD 2098 NEW AZD 2098;AZD-2098;AZD2098 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide Benzenesulfonamide, 2,3-dichloro-N-(3-methoxy-2-pyrazinyl)- AZD-2098 >=98% (HPLC) AZD-2098,inhibit,CC chemokine receptor,CCR,Inhibitor,AZD2098,AZD 2098 566203-88-1 C11H9Cl2N3O3S