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5-Fluoroorotic acid

5-Fluoroorotic acid
5-Fluoroorotic acid
CAS No.
703-95-7
Chemical Name:
5-Fluoroorotic acid
Synonyms
fo;foa;5-FOA;5' FOA;ro2-9945;nsc31712;ent-26398;Fluoxydin;WR 152520;5-Fluoroorotic
CBNumber:
CB6325772
Molecular Formula:
C5H3FN2O4
Formula Weight:
174.09
MOL File:
703-95-7.mol

5-Fluoroorotic acid Properties

Melting point:
278 °C (dec.)(lit.)
Boiling point:
143°C (rough estimate)
Density 
1.6154 (estimate)
storage temp. 
−20°C
solubility 
NH4OH 4 M: 50 mg/mL, clear, faintly yellow
Merck 
14,4176
CAS DataBase Reference
703-95-7(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36-36/37/39-27
WGK Germany  3
RTECS  UV7800000
10
Hazard Note  Irritant
HazardClass  IRRITANT
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…

5-Fluoroorotic acid price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 796999 5-Fluoroorotic acid hydrate 95% 703-95-7 250mg $77 2018-11-20 Buy
TCI Chemical F0382 5-Fluoroorotic Acid Monohydrate >95.0%(HPLC)(T) 703-95-7 1g $40 2018-11-22 Buy
TCI Chemical F0382 5-Fluoroorotic Acid Monohydrate >95.0%(HPLC)(T) 703-95-7 100mg $10 2018-11-22 Buy

5-Fluoroorotic acid Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Crystalline Solid

Uses

5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.

Uses

Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.

5-Fluoroorotic acid Preparation Products And Raw materials

Raw materials

Preparation Products


5-Fluoroorotic acid Suppliers

Global( 209)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.com sales1@qqpharm.com CHINA 137 55
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 sales@meilune.com China 4340 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40399 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24654 81
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44192 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912
86-027-87531808 sales@chemwish.com China 35929 56
Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028
+86-10-82967029 sales@ouhechem.com China 12610 60
BePharm Ltd 4001-647-117; 021-61629020
021-61629029 product@bidepharmatech.com China 24692 61

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