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Tosyl chloride

Tosyl chloride Chemical Properties Usage Production method
Tosyl chloride
Tosyl chloride structure
Chemical Name:
Tosyl chloride
PTSC;TsCl;fonyL;TOS-CL;p-TsCI;uenesuL;Tosylchlorid;TOSYL CHLORIDE;4-Tosyl chloride;p-tosyl chloride
Molecular Formula:
Formula Weight:
MOL File:

Tosyl chloride Properties

Melting point:
65-69 °C(lit.)
Boiling point:
134 °C10 mm Hg(lit.)
1,006 g/cm3
vapor pressure 
1 mm Hg ( 88 °C)
Flash point:
128 °C
storage temp. 
Store below +30°C.
methylene chloride: 0.2 g/mL, clear
Crystalline Powder
Water Solubility 
Moisture Sensitive
Stable. Substances to be avoided include strong bases and strong oxidizing agents and water. Moisture sensitive.
CAS DataBase Reference
98-59-9(CAS DataBase Reference)
NIST Chemistry Reference
Benzenesulfonyl chloride, 4-methyl-(98-59-9)
EPA Substance Registry System
p-Toluenesulfonyl chloride (98-59-9)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H314-H315-H318
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P305+P351+P338
Hazard Codes  C,Xi
Risk Statements  34-29-41-38
Safety Statements  26-36/37/39-45-27-39
RIDADR  UN 3261 8/PG 2
WGK Germany  1
Hazard Note  Corrosive
HazardClass  8
PackingGroup  II
HS Code  29049020
Toxicity LD50 orally in Rabbit: 4680 mg/kg

Tosyl chloride price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.08326 4-Toluenesulfonyl chloride for synthesis 98-59-9 250 g $29.04 2021-03-22 Buy
Sigma-Aldrich 240877 p-Toluenesulfonyl chloride ReagentPlus , ≥99% 98-59-9 5g $44.2 2021-03-22 Buy
Sigma-Aldrich 8.08326 4-Toluenesulfonyl chloride for synthesis 98-59-9 1 kg $78.44 2021-03-22 Buy
Sigma-Aldrich 240877 p-Toluenesulfonyl chloride ReagentPlus , ≥99% 98-59-9 100g $130 2021-03-22 Buy
Sigma-Aldrich 8.08326 4-Toluenesulfonyl chloride for synthesis 98-59-9 5 kg $192.4 2021-03-22 Buy

Tosyl chloride Chemical Properties,Uses,Production

Tosyl chloride

Toluenesulfonyl chloride is an important intermediate dyes in organic synthesis and raw materials for pesticides, there are three kinds of isomers, namely o-toluenesulfonyl chloride, m-toluenesulfonyl chloride and p-toluenesulfonyl chloride. Relative molecular mass is 190.65. All three stimulate skin and mucous membranes, commonly used is adjacent toluenesulfonyl chloride and p-toluenesulfonyl chloride.
O-toluenesulfonyl chloride, also known as 2-methyl-benzenesulfonyl chloride, 2-toluene-sulfonyl chloride, is colorless oily liquid. The relative density is 1.3383. Melting point is 10.2 ℃. Boiling point is 154 ℃ (4.800 × 103Pa), 126 ℃ (1.333 × 103Pa). The refractive index is 1.5565. It is insoluble in water, soluble in ether, benzene and ethanol.
M-toluenesulfonyl chloride, also known as 3-methyl-benzenesulfonyl chloride, 3-toluenesulfonyl chloride, is colorless oily liquid. Melting point is 11.7 ℃. Boiling point is 146 ℃ (2.933 × 103Pa). It is insoluble in water, soluble in alcohol, ether and benzene.
P-toluenesulfonyl chloride is also known as 4-methyl-benzenesulfonyl chloride, 4-toluenesulfonyl chloride. Precipitation from ether or petroleum ether is triclinic white flaky crystal. The relative density is 1.26. Melting point is 11. 7 ℃. Boiling point is 164 ℃ (4.4 × 103Pa), 151.6 ℃ (2.666 × 103Pa), 145~146 ℃ (2.000 × 103Pa), 134.5 ℃ (1.333 × 103Pa). It is insoluble in water, soluble in alcohol, benzene and ether.
Toluenesulfonyl chloride is called "TsCl", with strong nucleophilicity and substitution reaction with nucleophilic reagent. For example, reaction with the alcohol into the ester:
ROH + TsCl-Py → ROTs + Py + HCl-, reaction with amine and hydrazine respectively to generate the sulfonamide and sulfonyl hydrazide:

The above information were edited and collated by Xiaonan of Chemicalbook.

Chemical Properties

White flaky crystal. melting point is 71 ℃. Boiling point is 151.6 ℃ (1.67kPa), 145-146 ℃ (2.0kPa). Soluble in alcohol, ether and benzene, insoluble in water.


1. The goods is an intermediate for disperse dyes, azoic dyes, acid dyes. Also used in the production of drugs homosulfanilamide.
2. Used for the analysis Reagents, but also for organic synthesis, dye preparation and molecule rearrangement in the hormone synthesis.
3. Used for organic synthesis, sulfa drugs and as pesticide intermediates.

Production method

Toluene chlorosulfonation production into o-toluenesulfonyl chloride, at the same time p-toluenesulfonyl chloride is also generated. The filter cake was separated from the o-toluenesulfonyl chloride, refined to obtain p-toluenesulfonyl chloride.

Chemical Properties

White to yellow solid


It can be used for organic synthesis, for example: dyes, saccharin,etc.


Tosyl chloride is mainly used in the preparation of chemical derivatives in the pharmaceutical, plastics and organic chemical industries.

General Description

A white to gray powdered solid with a distinctive odor. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Used to make other chemicals.

Air & Water Reactions

Insoluble in water.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Contact allergens

Tosyl chloride is used mainly in the preparation of chemical derivatives in the pharmaceutical, plastics, and organic chemical industries.

Purification Methods

Material that has been standing for a long time contains tosic acid and HCl and has m ca 65-68o. It is purified by dissolving (10g) in the minimum volume of CHCl3 (ca 25mL) filtered, and diluted with five volumes (i.e. 125mL) of pet ether (b 30-60o) to precipitate impurities. The solution is filtered, clarified with charcoal and concentrated to 40mL by evaporation. Further evaporation to a very small volume gives 7g of white crystals which are analytically pure, m 67.5-68.5o. (The insoluble material is largely tosic acid and has m 101-104o.) [Pelletier Chem Ind (London) 1034 1953.] It also crystallises from toluene/pet ether in the cold, from pet ether (b 40-60o) or *benzene. Its solution in diethyl ether has been washed with aqueous 10% NaOH until colourless, then dried (Na2SO4) and crystallised by cooling in powdered Dry-ice. It has also been purified by dissolving in *benzene, washing with aqueous 5% NaOH , then dried with K2CO3 or MgSO4, and distilled under reduced pressure and can be sublimed at high vacuum [Ebel Chem Ber 60 20861927]. [Beilstein 11 IV 375.]

Tosyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Tosyl chloride Suppliers

Global( 456)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shouguang Nuomeng Chemical Co Ltd.
+86-536-5119508 CHINA 44 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 20918 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37127788 CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 8909 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
career henan chemical co
+86-371-86658258 CHINA 29954 58
+8619933070948 China 443 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58

Related articles

View Lastest Price from Tosyl chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 Tosyl chloride
US $0.00 / Kg/Drum 1Kg/Bag 99.5% 1000mt/year Jinan Finer Chemical Co., Ltd
2021-11-08 Tosyl chloride
US $10.00 / KG 500g 99% 2000MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
2021-10-29 Tosyl chloride
US $150.00 / ASSAYS 10g more than 99.6% 500kg/month HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD

Tosyl chloride Spectrum

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